Role of Brain-Derived Neurotrophic Factor in Beneficial Effects of Repetitive Transcranial Magnetic Stimulation for Upper Limb Hemiparesis after Stroke

Niimi, Masachika; Hashimoto, Kenji; Kakuda, Wataru; Miyano, Satoshi; Momosaki, Ryo; Ishima, Tamaki; Abo, Masahiro

doi:10.1371/journal.pone.0152241

Cited by 59 publications

(40 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been found that rTMS treatment improves symptoms of refractory depression, especially for agitation, by increasing the plasma level of BDNF (Yukimasa et al, 2006). Low-frequency rTMS also accelerates the motor function recovery in the affected limb after stroke by influencing BDNF gene polymorphism (Niimi et al, 2016). Here, we found that the level of BDNF was significantly upregulated in NSPCs after magnetic stimulation, indicating that rTMS promoted BDNF expression and secretion.…”

Section: Discussionsupporting

confidence: 49%

rTMS Regulates the Balance Between Proliferation and Apoptosis of Spinal Cord Derived Neural Stem/Progenitor Cells

Zhao

Qin

Sun

et al. 2020

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that uses electromagnetic fields to stimulate the brain. rTMS can restore an impaired central nervous system and promote proliferation of neural stem/progenitor cells (NSPCs), but optimal stimulus parameters and mechanisms underlying these effects remain elusive. The purpose of this study is to investigate the effect of different rTMS stimulus parameters on proliferation and apoptosis of spinal cord-derived NSPCs, the expression of brain-derived neurotrophic factor (BDNF) after rTMS, and the potentially underlying pathways. NSPCs were isolated from mice spinal cord and stimulated by different frequencies (1/10/20 Hz), intensities (0.87/1.24/1.58 T), and number of pulses (400/800/1,500/3,000) once a day for five consecutive days. NSPC proliferation was analyzed by measuring the neurosphere diameter and Brdu staining, apoptosis was detected by cell death enzyme-linked immunosorbent assay (ELISA) and flow cytometry, and NSPC viability was assessed by cell counting kit-8 assay. We found that specific parameters of frequency (1/10/20 Hz), intensity (1.24/1.58 T), and number of pulses (800/1,500/3,000) promote proliferation and apoptosis (p < 0.05 for all), but 20 Hz, 1.58 T, and 1,500 pulses achieved the optimal response for the NSPC viability. In addition, rTMS significantly promoted the expression of BDNF at the mRNA and protein level, while also increasing Akt phosphorylation (Thr308 and Ser473; p < 0.05). Overall, we identified the most appropriate rTMS parameters for further studies on NSPCs in vitro and in vivo. Furthermore, the effect of magnetic stimulation on NSPC proliferation might be correlated to BDNF/Akt signaling pathway.

show abstract

Section: Discussionsupporting

confidence: 49%

rTMS Regulates the Balance Between Proliferation and Apoptosis of Spinal Cord Derived Neural Stem/Progenitor Cells

Zhao

Qin

Sun

et al. 2020

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Although the transport of BDNF produced in the CNS occurs through the blood-brain barrier (BBB) via saturable systems, this data suggests that the fluctuations of this neurotrophin in the blood reflect changes in the nervous system (Poduslo and Curran, 1996 ; Asmundson et al, 1999 ). Furthermore, there are a significant number of studies demonstrating that occur variations in the serum levels of BDNF after interventions with effect in the CNS (Okamoto et al, 2008 ; Solati et al, 2015 ; Jeong et al, 2016 ; Kawazu et al, 2016 ; Niimi et al, 2016 ; Wens et al, 2016 ). These approaches therapeutics include antidepressant drugs (Brunoni et al, 2008 ), electroconvulsive therapy (ECT; Brunoni et al, 2014 ), TMS (Dall’Agnol et al, 2014 ) and tDCS (Brietzke et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Motor Cortex Excitability and BDNF Levels in Chronic Musculoskeletal Pain According to Structural Pathology

Caumo

Deitos

Carvalho

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

The central sensitization syndrome (CSS) encompasses disorders with overlapping symptoms in a structural pathology spectrum ranging from persistent nociception [e.g., osteoarthritis (OA)] to an absence of tissue injuries such as the one presented in fibromyalgia (FM) and myofascial pain syndrome (MPS). First, we hypothesized that these syndromes present differences in their cortical excitability parameters assessed by transcranial magnetic stimulation (TMS), namely motor evoked potential (MEP), cortical silent period (CSP), short intracortical inhibition (SICI) and short intracortical facilitation (SICF). Second, considering that the presence of tissue injury could be detected by serum neurotrophins, we hypothesized that the spectrum of structural pathology (i.e., from persistent nociception like in OA, to the absence of tissue injury like in FM and MPS), could be detected by differential efficiency of their descending pain inhibitory system, as assessed by the conditioned pain modulation (CPM) paradigm. Third, we explored whether brain-derived neurotrophic factor (BDNF) had an influence on the relationship between motor cortex excitability and structural pathology. This cross-sectional study pooled baseline data from three randomized clinical trials. We included females (n = 114), aged 19–65 years old with disability by chronic pain syndromes (CPS): FM (n = 19), MPS (n = 54), OA (n = 27) and healthy subjects (n = 14). We assessed the serum BDNF, the motor cortex excitability by parameters the TMS measures and the change on numerical pain scale [NPS (0–10)] during CPM-task. The adjusted mean (SD) on the SICI observed in the absence of tissue injury was 56.36% lower than with persistent nociceptive input [0.31(0.18) vs. 0.55 (0.32)], respectively. The BDNF was inversely correlated with the SICI and with the change on NPS (0–10)during CPM-task. These findings suggest greater disinhibition in the motor cortex and the descending pain inhibitory system in FM and MPS than in OA and healthy subjects. Likewise, the inter-hemispheric disinhibition as well as the dysfunction in the descending pain modulatory system is higher in chronic pain without tissue injury compared to a structural lesion. In addition, they suggest that a greater level of serum BDNF may be involved in the processes that mediate the disinhibition of motor cortex excitability, as well as the function of descending inhibitory pain modulation system, independently of the physiopathology mechanism of musculoskeletal pain syndromes.

show abstract

“…Though proBDNF has been shown to have opposite effects of BDNF in learning and memory, and despite the plethora of information tying BDNF to motor function, many articles investigating motor function and BDNF ignore proBDNF. However those that include plasma measurements of proBDNF have found that the serum levels are negatively correlated with motor function (for instance, in recovery after stroke (64). There has been evidence of BDNF being produced in smooth and skeletal muscle (65, 66), but no studies have specifically examined the effects of proBDNF on muscle.…”

Section: Discussionmentioning

confidence: 99%

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

Suire

Eitan

Shaffer

et al. 2017

Experimental Gerontology

View full text Add to dashboard Cite

Background Brain-derived neurotrophic factor (BDNF) is produced by cleavage of proBDNF, and BDNF and proBDNF may play antagonistic roles in nervous system development, learning, memory and neuronal stress resistance. BDNF and proBDNF are present in blood, but the origin and relative contributions of soluble and extracellular vesicle (EV)-associated levels are unknown. Methods In this study we used validated immunoassays to measure proBDNF and BDNF levels in plasma, total plasma EVs and a subpopulation of EVs enriched for neuronal origin (expressing the neuronal marker L1CAM) in 150 Baltimore Longitudinal Study of Aging participants with and without decline in walking speed (reflecting aging-associated motor decline). Results Levels of BDNF and proBDNF were highest in L1CAM+ EVs. Participants with walking speed decline had higher levels of proBDNF in L1CAM+ EVs compared to non-decliners, but no differences in proBDNF levels in plasma and total EV. Conclusions Our findings suggest that levels of proBDNF and BDNF in circulating L1CAM+ EVs might be used as biomarkers for conditions involving altered BDNF signaling.

show abstract

Role of Brain-Derived Neurotrophic Factor in Beneficial Effects of Repetitive Transcranial Magnetic Stimulation for Upper Limb Hemiparesis after Stroke

Cited by 59 publications

References 34 publications

rTMS Regulates the Balance Between Proliferation and Apoptosis of Spinal Cord Derived Neural Stem/Progenitor Cells

rTMS Regulates the Balance Between Proliferation and Apoptosis of Spinal Cord Derived Neural Stem/Progenitor Cells

Motor Cortex Excitability and BDNF Levels in Chronic Musculoskeletal Pain According to Structural Pathology

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

Contact Info

Product

Resources

About