Role of brain nitric oxide in the cardiovascular control of bullfrogs

Zena, Lucas A.; Gargaglioni, Luciane H.; Bícego, Kênia C.

doi:10.1016/j.cbpa.2013.03.020

Cited by 7 publications

(3 citation statements)

References 82 publications

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“…Animals were allowed 24 h to recover from the surgery before experiments began. This recovery time is sufficient for anurans to restore acid-base status (Andersen and Wang, 2002) or resting heart rate (Zena et al, 2013) after anesthesia.…”

Section: Surgical Preparationmentioning

confidence: 98%

Reprint of “Baroreflex function in anurans from different environments”

Hedrick

McNew

Crossley

2015

Comparative Biochemistry and Physiology Part A: Molecular &

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Anurans from terrestrial environments have an enhanced ability to maintain mean arterial blood pressure (Pm) through lymph mobilization in response to desiccation or hemorrhage compared with semiaquatic or aquatic species. Because short term blood pressure homeostasis is regulated by arterial baroreceptors, we compared baroreflex function in three species of anurans that span a range of environments, dehydration tolerance and an ability to maintain Pm with dehydration and hemorrhage. The cardiac limb of the baroreflex loop was studied using pharmacological manipulation of Pm with phenylephrine and sodium nitroprusside (20-200μgkg(-1)), and the resulting changes in heart rate (fH) were quantitatively analyzed using a four-parameter sigmoidal logistic function. Resting Pm in the aquatic species, Xenopus laevis, was 3.6±0.3kPa and was significantly less (P<0.005) than for the semiaquatic species, Lithobates catesbeianus (4.1±0.2kPa), or the terrestrial species, Rhinella marina (4.7±0.2kPa). The maximal baroreflex gain was not different among the three species and ranged from 12.1 to 14.3beatsmin(-1)kPa(-1) and occurred at Pm ranging from 3.0 to 3.8kPa, which were slightly below the resting Pm for each species. Mean arterial blood pressures at rest in the three species were near the saturation point of the baroreflex curve which provides the animals with a greater fH response range to hypotensive, rather than hypertensive, changes in Pm. This is consistent with the hypothesis that arterial baroreceptors are key sensory components that allow anurans to maintain Pm possibly by mobilization of lymphatic return in response to hypotension.

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Section: Surgical Preparationmentioning

confidence: 98%

Reprint of “Baroreflex function in anurans from different environments”

Hedrick

McNew

Crossley

2015

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Дослідження на жабах Lithobates catesbeianus показали, що NO, який продукується в мозковій тканині, регулює у них діяльність серцево-судинної системи. Ін'єкції в шлуночок мозку блокатора NO-синтаз L-NMMA (NGmonomethyl-L-arginine) викликали у цих тварин підвищення артеріального тиску, але не впливали на частоту серцевих скорочень [70].…”

Section: гсм амфібійunclassified

Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review)

Sukmansky¹

2019

Journal NAMSU

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Data, presented in this review, show that gaseous signaling molecules are a common biological system of bioregulators, which attribute to main kingdoms of life – animals, plants and bacteria. They confirm the similarity of their origin and developing by evolution. Gaseous signaling molecules (gasotransmitters) were first discovered and mostly researched in humans and mammals. Today are known gaseous signaling molecules such as: nitric oxide and reactive oxygen species, carbon monoxide, hydrogen sulfide, polysulfides and sulfur dioxide. It is proved that there are more gaseous signaling molecules and more pathways and mechanisms of their production in bacteria than in mammals, so their importance in evolution of living organisms on the planet Earth has decreased. However, in the process of evolution, in connection with the development from simple unicellular organisms into complex, higher multicellular, the number of functional targets that were influenced by gaseous signaling molecules has increased, i.e. their role has been getting increasingly complicated. The endogenous gaseous signaling molecules, produced by bacteria, regulate their metabolism, protect them against antibiotics and promote their colonization in the host organism. So they play an important role in the pathogenesis of infectious diseases in humans and animals. On the other side, the endogenous gaseous signaling molecules of humans and animals have mostly the negative impact on bacteria’s development and increase the host’s resistance to infections. Published data prove the similarity of function and role in pathology of gaseous signaling molecules in invertebrates with those in higher (vertebrate) animals. In particular, this relates to the nervous system and to the role of gaseous signaling molecules in the formation of memory and behavior. The gaseous signaling molecules of non-mammal vertebrata – fishes, amphibians, reptiles, and birds – are especially similar to mammals and humans. Isolated tissues of brain, eyes and lungs of poikilothermic non-mammalian vertebrates (fishes, amphibians and reptiles) are used to study the possible role of gaseous signaling molecules in the pathogenesis of diseases affecting these organs in humans. Further researches of the evolution of gaseous signaling molecules by comparing them in living beings of different levels of development may be useful for exposure of new ways of application in medicine and adjacent fields. The study of their role in the pathogenesis of pathological processes increases the possibilities of treatment and prevention of diseases via utilization of gaseous signaling molecules, their donors, precursors, and inhibitors. Key words: gaseous signaling molecules, evolution, vertebrate, invertebrate, bacteria, biological action, role in pathology. For citation: Sukmansky OI. Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review). Journal of the National Academy of Medical Sciences of Ukraine. 2019;25(4):373–382

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“…Vasoactive drugs may also trigger other regulatory mechanisms for blood pressure regulation, such as the renin–angiotensin–aldosterone system, which can influence the final results (Cowley, 1992; Guyton, 1991). Moreover, the vasoactive drugs, particularly the nitric oxide donor sodium nitroprusside, may exert direct effects within the central nervous system and the sinoatrial node that would violate the premise of the Oxford method and affect the estimated baroreflex (Bergel et al, 1980; Coleman, 1980; Klimaschewski et al, 1992; Zena et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The nonpharmacological sequence method provides a reliable evaluation of baroreflex sensitivity in fish

et al. 2021

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The most commonly used technique to study the barostatic regulation of blood pressure in ectothermic vertebrates consists of determining the heart rate response to pharmacological manipulations of blood pressure, the so‐called “Oxford method.” Although well established, the Oxford method has some important limitations, such as induction of hypervolemia in small animals and undesired effects of vasoactive drugs on central and peripheral baroreflex components. As an alternative, the sequence method, which consists in the computerized evaluation of naturally‐occurring baroreflex adjustments of heart rate without the need for pharmacological administrations, was developed to study baroreflexes. In the present study, we compare this sequence method with the Oxford technique in two teleost species with different life styles, and we assess the optimal software configuration for the employment of the sequence method in fish. Calculation of baroreflex gain through the sequence method was adequate and reliable when the software was configured to search for baroreflex sequences with a minimum length of three cardiac cycles with a delay of one cardiac cycle between fluctuations in mean ventral aortic blood pressure and reflex changes in pulse interval. When properly configured, the sequence and the Oxford methods yielded similar determinations of the baroreflex gain in fish.

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Role of brain nitric oxide in the cardiovascular control of bullfrogs

Cited by 7 publications

References 82 publications

Reprint of “Baroreflex function in anurans from different environments”

Reprint of “Baroreflex function in anurans from different environments”

Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review)

The nonpharmacological sequence method provides a reliable evaluation of baroreflex sensitivity in fish

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