Role of breast vascular calcification in predicting cardiovascular risk

Mendonça, Roberto Moreno; Araruna, Arthur Luiz Norte Gomes Pereira; Alves, Flora V.; Souza, Thaís Rossana Cruz de; Egito, Eryvaldo Sócrates Tabosa do; Gonçalves, Ana Katherine

doi:10.1002/ijgo.12716

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Interestingly, Margolies et al (11) firstly demonstrated a strong quantitative association of BAC with coronary artery calcium score on CT and its superiority to individual standard cardiovascular risk factors. This association reinforces the potential of BAC to ameliorate cardiovascular risk stratification in women erroneously classified at low-intermediate cardiovascular risk by traditional scores, without additional imaging, costs, or radiation exposure (12)(13)(14)(15)(16)(17).…”

Section: Introductionsupporting

confidence: 71%

Semiquantitative score of breast arterial calcifications on mammography (BAC-SS): intra- and inter-reader reproducibility

Trimboli¹,

Codari²,

Cozzi³

et al. 2021

Quant Imaging Med Surg

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Background: Breast arterial calcifications (BAC), representing Mönckeberg's sclerosis of the tunica media of breast arteries, are an imaging biomarker for cardiovascular risk stratification in the female population.Our aim was to estimate the intra-and inter-reader reproducibility of a semiquantitative score for BAC assessment (BAC-SS).Methods: Consecutive women who underwent screening mammography at our center from January 1 st to January 31 st , 2018 were retrieved and included according to BAC presence. Two readers (R1 and R2) independently applied the BAC-SS to medio-lateral oblique views, obtaining a BAC score by summing: (I) number of calcified vessels (from 0 to n); (II) vessel opacification, i.e., the degree of artery coverage by calcium bright pixels (0 or 1); and (III) length class of calcified vessels (from 0 to 4). R1 repeated the assessment 2 weeks later. Scoring time was recorded. Cohen's κ statistics and Bland-Altman analysis were used.Results: Among 408 women, 57 (14%) had BAC; 114 medio-lateral oblique views were assessed. Median BAC score was 4 [interquartile range (IQR): 3-6] for R1 and 4 (IQR: 2-6) for R2 (P=0.417) while median scoring time was 156 s (IQR: 99-314 s) for R1 and 191 s (IQR: 137-292 s) for R2 (P=0.743). Bland-Altman analysis showed a 77% intra-reader reproducibility [bias: 0.193, coefficient of repeatability (CoR): 0.955] and a 64% inter-reader reproducibility (bias: 0.211, CoR: 1.516). Cohen's κ for BAC presence was 0.968 for intra-reader agreement and 0.937 for inter-reader agreement.Conclusions: Our BAC-SS has a good intra-and inter-reader reproducibility, within acceptable scoring times. A large-scale study is warranted to test its ability to stratify cardiovascular risk in women.

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Section: Introductionsupporting

confidence: 71%

Semiquantitative score of breast arterial calcifications on mammography (BAC-SS): intra- and inter-reader reproducibility

Trimboli¹,

Codari²,

Cozzi³

et al. 2021

Quant Imaging Med Surg

View full text Add to dashboard Cite

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“…Однако о корреляции кальцинированных артерий других органов с риском сердечно-сосудистых событий известно меньше [3]. Также в литературе показана связь наличия сосудистых кальцинатов в молочной железе с кальцинозом коронарных артерий [4,5], стенок аорты [6] и с артериальной гипертензией, сахарным диабетом, хронической болезнью почек [7]. D. Ružičić et al…”

Section: Introductionunclassified

Evaluation of Breast Vascular Calcifications as a Predictor for Coronary Artery Calcification

Bazhenova

Puchkova

Мершина

et al. 2021

Vestn. rentgenol. radiol.

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Background. Cardiovascular diseases are one of the main causes of death among women, and current prevention paradigms may not be sufficient in this group. In this context, it has been suggested that the detection of breast vascular calcifications can improve the screening and assessment of the risk of cardiovascular diseases in apparently healthy women.Objective: to study the role of breast vascular calcifications as a potential predictor for coronary artery calcification. Material and methods. Examinations were made in 123 patients who underwent digital mammography and cardiac computed tomography to estimate a coronary artery calcium score.Results. The use of the Wilcoxon-Mann-Whitney W-test for abnormal distribution showed a relationship between the presence of breast vascular calcifications and calcium score (p< 0.001), and that between aortic wall calcification and calcium score (p< 0.001).Conclusion. Breast vascular calcifications detected by mammography are an indicator of a higher frequency of coronary artery calcification and, apparently, a predictor for the increased risk of cardiovascular disease.

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Assessing cardiovascular risk with mammography and non-contrast chest CT: A review of the literature and clinical implications

Roshan,

Cury,

Lampen-Sachar

2023

Clinical Imaging

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Role of breast vascular calcification in predicting cardiovascular risk

Abstract: We identified a positive association between presence of breast vascular calcification and high coronary calcium score, and thus with high cardiovascular risk.

Cited by 3 publications

References 3 publications

Semiquantitative score of breast arterial calcifications on mammography (BAC-SS): intra- and inter-reader reproducibility

Semiquantitative score of breast arterial calcifications on mammography (BAC-SS): intra- and inter-reader reproducibility

Evaluation of Breast Vascular Calcifications as a Predictor for Coronary Artery Calcification

Assessing cardiovascular risk with mammography and non-contrast chest CT: A review of the literature and clinical implications

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