Role of C-erbB2 expression in gallbladder cancer

Kumari, Niraj; Kapoor, Vinay K.; Krishnani, Narendra; Kumar, Kamlesh; Baitha, Dinesh Kumar

doi:10.4103/0377-4929.94862

Cited by 27 publications

(17 citation statements)

References 3 publications

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“…The TT genotype of rs4979462 and rs6478106 was more frequent in the Her-2 (+) patients. According to researches involved Her-2 indicated that Her-2 could regulate cell growth and proliferation through many pathways in different diseases ( 32 ). It acts as a key marker in diagnosis and predicts the prognosis of cancers ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

A case-control study about the association between vascular endothelial growth inhibitor gene polymorphisms and breast cancer risk in female patients in Northeast China

Han¹,

Liu²,

Xu³

et al. 2016

Chinese Journal of Cancer Research

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Objective The inhibition of the neovascularization in tumors is a potential therapeutic target of cancer. Vascular endothelial growth inhibitor (VEGI) is a member of the TNF superfamily which has the ability to suppress the formation of new vessels in tumors. In order to study the association between VEGI gene polymorphisms and breast cancer risk, a case-control study was conducted in Chinese Han women in Northeast China. Methods Our study involved 708 female breast cancer patients and 685 healthy volunteers. Four SNPs of VEGI gene were analyzed through the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The association between VEGI gene polymorphisms and breast cancer risk was analyzed in our study. The relation between VEGI gene variants and clinical features of breast cancer including lymph node (LN) metastasis, estrogen receptor (ER), progestrogen receptor (PR), tumor protein 53 (p53), human epidermal growth factor receptor 2 (Her-2) and triple negative (ER-/PR-/Her-2-) status was analyzed as well.Results We found that the CT genotype and T allele of rs6478106 were more frequent in patients than in controls. There was also a statistical difference in the distribution of Crs6478106Grs4263839 haplotype between patients and controls. In addition, SNP rs6478106 and rs4979462 were related with the Her-2 status. Conclusions Our results suggest that VEGI gene variants may be related to the breast cancer risk and the clinical features of breast cancer in Chinese Han women in Northeast China.

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Section: Discussionmentioning

confidence: 99%

A case-control study about the association between vascular endothelial growth inhibitor gene polymorphisms and breast cancer risk in female patients in Northeast China

Han¹,

Liu²,

Xu³

et al. 2016

Chinese Journal of Cancer Research

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“…Therefore, it can be hypothesized that some oncogene is associated with in Gallbladder cancer progression. In a study from India, C-erbB2 was frequently expressed in well differentiated and stage II to stage IV in about 9.4% of GBC cases[90]. A recent report showed HER2/neu overexpression occurred in 14% of the advanced gallbladder cancer cases, and this subgroup was expected to be benefited from HER2/neu pathway inhibitors[91].…”

Section: Genetic Alterations In Gbcmentioning

confidence: 99%

“…Existing data various greatly, despite of same grade and stage of the included study subjects. Table 4[97-101] and Table 5[54,66,75,84,86,90,102-180] are summarizing global and single gene expression studies reported in GBC respectively.…”

Section: Gene Expression Studies In Gbcmentioning

confidence: 99%

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Sharma

Gupta

et al. 2017

WJG

323

256

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Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between epidemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically reviewed published literature on gallbladder cancer from online search engine PubMed (http://www.ncbi.nlm.nih.gov/pubmed). Various keywords used for retrieval of articles were Gallbladder, cancer Epidemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines (http://www.ncbi.nlm.nih.gov/pubmed,https://scholar.google.co.in/, http://www.medline.com/home.jsp). Most of the articles published from 1982 to 2015 in peer reviewed journals have been included in this review.

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“…Ki67 was highly expressed in these poorly differentiated cases (mean MIB1 LI= 62) as compared to 21 in well differentiated ones (p= 0.000).Ki67 overexpression has been related to poor tumor differentiation in some of the previous studies as well. 6 CerbB-2 has been related to advanced tumor stage 7 in gall bladder adenocarcinomas. In our cases, 12 out of 16 cases (75%) which showed full thickness invasion, were positive for CerbB2 as compared to only 67% of those with muscular propria invasion.…”

Section: Discussionmentioning

confidence: 99%

Expression of Ki67 and CerbB-2 in Gall Bladder, Oesophageal, Small Intestinal and Colorectal Adenocarcinomas: A Study from a Tertiary Care Hospital in Western U.P.

Garg¹,

Agarwal²

2019

IJCMR

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Introduction: Gall bladder cancer is the commonest biliary tract malignancy with poor prognosis. Oesophageal adenocarcinomas are aggressive with very poor survival. Adenocarcinomas of small intestine are rare, in comparison to colorectal carcinomas. We studied the expression of two commonly studied immunohistochemical markers Ki67 and CerbB-2 in gall bladder and gastrointestinal carcinomas, to find out their prognostic significance. Material and Methods: Histopathologically confirmed cases of adenocarcinomas of gall bladder (19 cases), oesophagus (3 cases), small intestine (3 cases) and colorectal region (8 cases) were included. Formalin fixed paraffin embedded tissue blocks were retrieved and sections were studied immunohistochemically for expression of Ki67 and CerbB-2. Tumors of all stages and grades were studied. Results: Our study revealed a significantly high Ki67 in neoplastic glands of gall bladder, oesophageal, small intestinal and colorectal adenocarcinomas as compared to the non neoplastic areas. The Ki67 labelling index was higher in moderately and poorly differentiated areas as well as mucinous and signet ring type adenocarcinomas. There was no relation with stage/depth of tumor invasion. CerbB-2 was significantly overexpressed in gall bladder and colorectal adenocarcinomas. Expression was higher in advanced stage and greater depth of invasion. There was no association with tumor grade or type. In esophageal and small intestine adenocarcinomas, expression was not related to either tumor stage or grade. Conclusion: A panel of Ki67 and CerbB-2 in gastrointestinal and biliary tract malignancies may correlate well with different prognostic indicators in these malignancies, like tumor stage, histologic type and grade.

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Role of C-erbB2 expression in gallbladder cancer

Cited by 27 publications

References 3 publications

A case-control study about the association between vascular endothelial growth inhibitor gene polymorphisms and breast cancer risk in female patients in Northeast China

A case-control study about the association between vascular endothelial growth inhibitor gene polymorphisms and breast cancer risk in female patients in Northeast China

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Expression of Ki67 and CerbB-2 in Gall Bladder, Oesophageal, Small Intestinal and Colorectal Adenocarcinomas: A Study from a Tertiary Care Hospital in Western U.P.

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