Role of C-reactive protein in acute pancreatitis: an observational study in a tertiary care centre

Abstract

Background: Acute pancreatitis is significant reason for intense abdominal torment. The job of diagnostic markers (pancreatic enzymes like amylase and lipase) as prognostic pointers has been a disappointment. C-reactive protein (CRP) assessment is modest and effective option. In this concentrate we have endeavored to check whether a solitary and early assessment of CRP levels is a viable indicator of morbidity and mortality in acute pancreatitis.Methods: This was a prospective observational study done at Government Medical College Srinagar Kashmir for a period of three years from May 2015 to April 2018. Fifty patients diagnosed to have acute pancreatitis were included in this study. Their CRP levels were sent on second day of admission and computed tomography (CT) scan done after 72 hours of admission. Demographic variables were recorded along with local and systemic complications and compared with CRP levels.Results: In this study of 50 patients, we found that most of the patients of pancreatitis were young to middle aged males, a majority of whom belonged to fourth decade of life. We found that levels of CRP rise as age and severity progresses. CRP levels also remains on higher side in various local complications like necrosis, acute fluid collection etc., however a statistical significance could not be ascertained.Conclusions: Acute Pancreatitis is a life-threatening disease with a wide spectrum of clinical symptoms. C Reactive Protein as a prognostic marker has shown promising results in earlier studies. There is an need to further study its role so as to reduce the mortality and morbidity associated with acute pancreatitis.

The role of erythrocyte distribution width in predicting poor outcomes in geriatric patients with acute pancreatitis

“…9 In another study investigating the effect of CRP on prognosis in acute pancreatitis, it was found that CRP was higher in patients with local complications present on computed tomography, but it was not statistically significant. 14 In our study, there was a statistically significant relationship between high RDW and CRP and mortality, but although high neutrophil and low lymphocyte levels were evident in non-surviving patients, there was no statistically significant relationship between high neutrophil levels and low lymphocytes and mortality. There was a statistically significant correlation between low albumin and mortality.…”

“…10,11 Some studies have previously been conducted to evaluate the association of RDW with a poor prognosis in patients with pancreatitis, mostly comparing patients with pancreatitis with patients without pancreatitis. 2,6,9,[12][13][14] The relationship of RDW with mortality was also investigated in patients with acute coronary syndrome, acute appendicitis with inflammation similar to acute pancreatitis, infective diseases such as COVID-19, and malignancies. 11,[15][16][17] It can be quite difficult to predict the prognosis of acute pancreatitis, which has many causes, including idiopathic, especially in geriatric patients.…”

The role of predictive and prognostic values of inflammatory markers in acute pancreatitis: a narrative review

“…Further research is needed to better understand the role of CRP in mitigating the mortality and morbidity associated with AP. [89] Patients with severe pancreatitis exhibited a more significant elevation in CRP levels. One day after admission, the average CRP level was 280 mg/L in patients with hemorrhagic pancreatitis and 45 mg/L in those with mild pancreatitis.…”

“…Further research is needed to better understand the role of CRP in mitigating the mortality and morbidity associated with AP. [89]…”