Role of CA125 in the Diagnosis of Acute Appendicitis

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

“…The risk of bias concerning the index test was considered low in four of the studies [11][12][13][14] and unclear in one of them [15]. The risk of bias concerning the reference standard was considered low in four of the studies [11][12][13][14] and unclear in one of them [15]. The risk of bias concerning flow and timing was considered low in two of the studies [11,14], unclear in two of the studies [12,13] and high in one of them [15].…”

“…None of the studies involved pediatric populations. Three studies stratified their population and analyses by sex [12][13][14], and one of them included only a male population [13].…”

“…One study exclusively compared patients with uncomplicated AA (NCAA) and complicated AA (CAA) with no control group [11]. Three studies compared an AA group with a control group [12][13][14]. One study did not provide sufficient data to determine this information [15].…”

“…Three studies specifically evaluated potential conditions that could have altered serum CA-125 levels [12,14,15] including congestive heart failure, chronic lung disease, liver cirrhosis, inflammatory bowel disease, any malignancy, pregnancy (first trimester), endometriosis, and recent abdominal surgery. Sevinç et al [13] opted to exclude the female population from the study, arguing that ovarian disorders and fluctuations during menstrual cycles could alter the results. Two studies [11,13] did not specify specific exclusions regarding possible confounders of CA-125 elevation.…”

“…Sevinç et al [13] opted to exclude the female population from the study, arguing that ovarian disorders and fluctuations during menstrual cycles could alter the results. Two studies [11,13] did not specify specific exclusions regarding possible confounders of CA-125 elevation.…”