Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004

López, David S.; Wang, Run; Tsilidis, Konstantinos K.; Zhu, Huirong; Daniel, Carrie R.; Sinha, A. K.; Canfield, Steven E.

doi:10.1371/journal.pone.0123547

Cited by 36 publications

(18 citation statements)

References 29 publications

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“…To date, few studies have specifically examined the potential role of dietary constituents on ED. Recently, a cross-sectional study reported a 39% reduction in risk of ED with higher caffeine intake (intake equivalent to 2–3 cups of coffee/d) ( 45 ), although the relative importance of the polyphenol content of coffee was not addressed. The addition of either caffeine intake or caffeine/methylxanthine-containing beverages (tea and coffee) to our model did not attenuate the relation, suggesting that the benefits may be more likely related to the flavonoid content.…”

Section: Discussionmentioning

confidence: 99%

Dietary flavonoid intake and incidence of erectile dysfunction

Cassidy

Franz

Rimm

2016

The American Journal of Clinical Nutrition

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Background: The predominant etiology for erectile dysfunction (ED) is vascular, but limited data are available on the role of diet. A higher intake of several flavonoids reduces diabetes and cardiovascular disease risk, but no studies have examined associations between flavonoids and erectile function.Objective: This study examined the relation between habitual flavonoid subclass intakes and incidence of ED.Design: We conducted a prospective study among 25,096 men from the Health Professionals Follow-Up Study. Total flavonoid and subclass intakes were calculated from food-frequency questionnaires collected every 4 y. Participants rated their erectile function in 2000 (with historical reporting from 1986) and again in 2004 and 2008.Results: During 10 y of follow-up, 35.6% reported incident ED. After multivariate adjustment, including classic cardiovascular disease risk factors, several subclasses were associated with reduced ED incidence, specifically flavones (RR = 0.91; 95% CI: 0.85, 0.97; P-trend = 0.006), flavanones (RR = 0.89; 95% CI: 0.83, 0.95; P-trend = 0.0009), and anthocyanins (RR = 0.91; 95% CI: 0.85, 0.98; P-trend = 0.002) comparing extreme intakes. The results remained statistically significant after additional adjustment for a composite dietary intake score. In analyses stratified by age, a higher intake of flavanones, anthocyanins, and flavones was significantly associated with a reduction in risk of ED only in men <70 y old and not older men (11–16% reduction in risk; P-interaction = 0.002, 0.03, and 0.007 for flavones, flavanones, and anthocyanins, respectively). In food-based analysis, higher total intake of fruit, a major source of anthocyanins and flavanones, was associated with a 14% reduction in risk of ED (RR = 0.86; 95% CI: 0.79, 0.92; P = 0.002).Conclusions: These data suggest that a higher habitual intake of specific flavonoid-rich foods is associated with reduced ED incidence. Intervention trials are needed to further examine the impact of increasing intakes of commonly consumed flavonoid-rich foods on men’s health.

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Section: Discussionmentioning

confidence: 99%

Dietary flavonoid intake and incidence of erectile dysfunction

Cassidy

Franz

Rimm

2016

The American Journal of Clinical Nutrition

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“…10,11 Among 3,724 males over the age of 20 who participated in the National Health and Nutrition Examination Survey, the men who consumed the amount of caffeine present in about 2 or 3 cups of coffee daily had a 42% lower occurrence of erectile dysfunction. 12 Epidemiological studies indicate that coffee consumption may reduce the likelihood of developing obesity. Especially among individuals who are genetically predisposed to develop obesity, higher coffee consumption is associated with lower body mass index.…”

Section: Obesitymentioning

confidence: 99%

Coffee for Cardioprotection and Longevity

O’Keefe

DiNicolantonio

Lavie³

2018

Progress in Cardiovascular Diseases

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Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral. Coffee consumption is associated with improvements in some CV risk factors, including type 2 diabetes (T2D), depression, and obesity. Chronic coffee consumption also appears to protect against some neurodegenerative diseases, and is associated with improved asthma control, and lower risks for liver disease and cancer. Habitual intake of 3 to 4 cups of coffee appears to be safe and is associated with the most robust beneficial effects. However, most of the studies regarding coffee's health effects are based on observational data, with very few randomized controlled trials. Furthermore, the possible benefits of coffee drinking must be weighed against potential risks, which are generally due to its high caffeine content, including anxiety, insomnia, headaches, tremulousness, and palpitations. Coffee may also increase risk of fracture in women, and when consumed in pregnancy coffee increases risk for low birth weight and preterm labor.

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“…2,5e8 Improvements in erectile function can be achieved by the adoption of healthier lifestyle habits. In particular, dietary modifications, 9 such as adherence to a Mediterranean diet 10 and increased intake of dietary antioxidants 11 and caffeine, 12 seem to be the most promising and cost-efficient approaches to ED therapy. The hypothesis behind the consumption of antioxidants in ameliorating ED symptoms is the fact that ED is often a precursor of impending CV problems, with antioxidant compounds having known beneficial effects in lowering CV risk.…”

Section: Introductionmentioning

confidence: 99%

Sexual Dysfunction Among Young Men: Overview of Dietary Components Associated With Erectile Dysfunction

Mykoniatis

Grammatikopoulou

Bouras

et al. 2018

The Journal of Sexual Medicine

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Background Sexual dysfunction is relatively common in young men, presenting in diverse manifestations, including erectile dysfunction (ED), for which dietary modifications, including increased intake of dietary antioxidants, have been suggested as promising and cost-efficient approaches. Aim To assess the consumption of selected dietary antioxidants, in particular flavonoids, in relation to ED symptoms in young men. Methods Men 18 to 40 years old were invited to complete an anonymous web-based questionnaire for this case-control study. ED was diagnosed with the International Index of Erectile Function (IIEF) and flavonoid intake was recorded using food-frequency questionnaires, with an emphasis on flavonoid-rich foods such as coffee, fruits, etc. Participants without ED (IIEF score ≥ 26; n = 264) formed the control group and those with ED (IIEF score < 26; n = 86) formed the case group. Outcomes Dietary flavonoid intake. Results Men with ED reported a lower median monthly intake of total flavonoids (−2.18 g, 95% CI = −3.15 to −1.21, P < .001) and all flavonoid subclasses (P < .001) compared with controls. Adjustment of intake for age and body mass index showed that consumption of flavonoids 50 mg/day lowered the risk for ED by 32% (odds ratio = 0.68, 95% CI = 0.55–0.85, P < .001). Of all recorded flavonoids, flavones appeared to contribute the most to healthy erectile function. Controls reported a greater consumption of vegetables and fruits, a lower intake of dairy and alcoholic beverages, and a less intense smoking habit compared with cases (P < .001). Clinical Implications Increased intake of fruits, vegetables, and flavonoids decreases the risk of ED in young men. Strength and Limitations The strength of this study stems from the innovative hypothesis, the young age of participants, and the suggested therapeutic effects of cheap dietary components against ED. Limitations include the relatively small sample and cross-sectional design. Conclusion Low flavonoid—in particular flavone—intake is associated with ED in young adult men.

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Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004

Cited by 36 publications

References 29 publications

Dietary flavonoid intake and incidence of erectile dysfunction

Dietary flavonoid intake and incidence of erectile dysfunction

Coffee for Cardioprotection and Longevity

Sexual Dysfunction Among Young Men: Overview of Dietary Components Associated With Erectile Dysfunction

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