Role of calcitonin in management of musculoskeletal pain

Arendt‐Nielsen, Lars; Hoeck, Hans Christian; Karsdal, Morten; Christiansen, Claus

doi:10.4081/rr.2009.e12

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Modulatory effects on CPM have been found by dexmedetomidine (a selective α(2)‐adrenoceptor agonist) (Baba et al., ) and apomorphine (a non‐specific dopamine agonist) (Treister et al., ). Recently it has been suggested that calcitonin may interact with the descending pain modulation as calcitonin interacts with serotonin, and a synergetic analgesic effect between calcitonin and serotonin reuptake inhibitor antidepressants has been shown (Arendt‐Nielsen et al., ) indicating various alternative options to interact with the descending pathways.…”

Section: How To Interact With the Central Sensitisation In Chronic Pain?mentioning

confidence: 99%

Assessment and manifestation of central sensitisation across different chronic pain conditions

Arendt-Nielsen

Morlion

Perrot

et al. 2017

European Journal of Pain

517

494

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Different neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features. The fundamental understanding and quantitative assessment of particularly some of the central sensitisation mechanisms can be translated from preclinical studies into the clinic. The clinical perspectives are implementation of such novel information into diagnostics, mechanistic phenotyping, prevention, personalised treatment, and drug development. The aims of this paper are to introduce and discuss (1) some common fundamental central pain mechanisms, (2) how they may translate into the clinical signs and symptoms across different chronic pain conditions, (3) how to evaluate gain and loss of function using quantitative pain assessment tools, and (4) the implications for optimising prevention and management of pain. The chronic pain conditions selected for the paper are neuropathic pain in general, musculoskeletal pain (chronic low back pain and osteoarthritic pain in particular), and visceral pain (irritable bowel syndrome in particular). The translational mechanisms addressed are local and widespread sensitisation, central summation, and descending pain modulation. Significance Central sensitisation is an important manifestation involved in many different chronic pain conditions. Central sensitisation can be different to assess and evaluate as the manifestations vary from pain condition to pain condition. Understanding central sensitisation may promote better profiling and diagnosis of pain patients and development of new regimes for mechanism based therapy. Some of the mechanisms underlying central sensitisation can be translated from animals to humans providing new options in development of therapies and profiling drugs under development.

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Section: How To Interact With the Central Sensitisation In Chronic Pain?mentioning

confidence: 99%

Assessment and manifestation of central sensitisation across different chronic pain conditions

Arendt-Nielsen

Morlion

Perrot

et al. 2017

European Journal of Pain

517

494

View full text Add to dashboard Cite

show abstract

“…At present there is a considerable debate in the literature on the effect of sCT on pain, albeit no long term RCT have investigated these effects carefully 37 . In the CSMC021C2301 study we observed an effect on pain, stiffness and function, but as a hierarchical testing procedure was applied for the co-primary endpoints no beneficial treatment effect can be claimed as the first endpoint of JSN failed to show significance.…”

Section: Pain and Functionmentioning

confidence: 99%