Role of calreticulin from parasites in its interaction with vertebrate hosts

Ferreira, Viviana P.; Molina, Marı́a; Valck, Carolina; Rojas, Álvaro; Aguilar, Lorena; Ramı́rez, Galia; Schwaeble, Wilhelm; Ferreira, Arturo

doi:10.1016/j.molimm.2003.11.018

Cited by 86 publications

(62 citation statements)

References 146 publications

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“…Authors speculated that those molecules could be acting as a facilitator of entering and intercellular movement of the RKN at the early phases of the parasitism. However, presence of different candidate molecules in the nematode secretions supports the thoughts of the NFS formation as well as hypothesis of the parasitism (Ferreira et al 2004;Dubreuil et al 2007;Bellafiore et al 2008). Moreover, a molecule associated to rhizobial Nod factor acting as an initial signal of RKN-plant parasitism (Weerasinghe et al 2005).…”

Section: Molecular Mechanism Of Establishing Nematode-induced Feedingsupporting

confidence: 59%

How Durable is Root Knot Nematode Resistance in Tomato?

Rashid¹,

Al-Mamun²,

Uddin³

2017

Plant Breed. Biotech.

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Among the plant parasitic nematodes, root knot nematode (RKN) is the most devastating in tomato growing regions. Controlling RKN mostly relies on nematicides. Since chemical application is limited due to adverse environmental effect, alternative approaches are required. Although there are some alternatives, but resistance cultivars are getting popularity in the farmer's field because of simplicity, cost-effective and environment safety. Genes conferring resistance to RKN have already been identified followed by the introgression into elite cultivars. Currently, natural resistance genes (R genes) are used in conventional breeding programmes. Simultaneously, molecular research is going on to characterize and map the linked markers for the detected resistant phenotypes. Currently, it is a prominent threat to maintain the durability of existing R genes. However, durability of host resistance govern by co-evolution of resistance genes from plants and (a)virulence genes from nematodes. So, understanding the mechanisms underlying co-evolution is essential for the durability of R genes. Here we review the existing potential natural resistance in tomato against RKN, currently used resistance mechanisms between RKN and tomato, influential factors of durability of natural resistance genes and opportunity to get more durable resistance in tomato.

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Section: Molecular Mechanism Of Establishing Nematode-induced Feedingsupporting

confidence: 59%

How Durable is Root Knot Nematode Resistance in Tomato?

Rashid¹,

Al-Mamun²,

Uddin³

2017

Plant Breed. Biotech.

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“…In contrast, protozoan and metazoan CRT appear to be secreted proteins. Several protozoan and metazoan parasites, including Trypanosoma brucei and T. cruzi (the causative agents of sleeping sickness and Chagas' disease, respectively), Necator americanus (hookworm) and pathogenic species of schistosome have been shown to secrete CRT and/or express CRT on their surface (Ferreira et al, 2004a;Pritchard et al, 1999;Jones et al, 2006). Parasite CRT inhibits the host complement system by binding to C1q, the first component of the classical complement cascade (Ferreira et al, 2004b;Kasper et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Use of recombinant calreticulin and cercarial transformation fluid (CTF) in the serodiagnosis of Schistosoma mansoni

et al. 2011

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“…A rabbit polyclonal antiserum was generated against rTcCRT. 6,21 Previous to the immunization, a preimmune serum was obtained. By serial dilutions, the immune serum had a titer of 10…”

Section: Methodsmentioning

confidence: 99%

“…To maintain this cycle and consequently, its survival, the parasite uses multiple strategies to evade the host immune system. One of its main virulence factors is calreticulin (TcCRT), 5 a 47 kDa lectin chaperone, highly conserved among species, bearing an endoplasmic reticulum (ER)-retention signal KEDL on the carboxiterminus domain, 6 similar to mammalian CRT. 7,8 The TcCRT is also present in other organelles in free parasites, including Golgi, cytoplasm, nucleus, and kinetoplast.…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages

González

Valck

Sánchez

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Trypanosoma cruzi calreticulin (TcCRT), a 47-kDa chaperone, translocates from the endoplasmic reticulum to the area of flagellum emergence. There, it binds to complement components C1 and mannan-binding lectin (MBL), thus acting as a main virulence factor, and inhibits the classical and lectin pathways. The localization and functions of TcCRT, once the parasite is inside the host cell, are unknown. In parasites infecting murine macrophages, polyclonal anti-TcCRT antibodies detected TcCRT mainly in the parasite nucleus and kinetoplast. However, with a monoclonal antibody (E2G7), the resolution and specificity of the label markedly improved, and TcCRT was detected mainly in the parasite kinetoplast. Gold particles, bound to the respective antibodies, were used as probes in electron microscopy. This organelle may represent a stopover and accumulation site for TcCRT, previous its translocation to the area of flagellum emergence. Finally, early during T. cruzi infection and by unknown mechanisms, an important decrease in the number of MHC-I positive host cells was observed.

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Role of calreticulin from parasites in its interaction with vertebrate hosts

Cited by 86 publications

References 146 publications

How Durable is Root Knot Nematode Resistance in Tomato?

How Durable is Root Knot Nematode Resistance in Tomato?

Use of recombinant calreticulin and cercarial transformation fluid (CTF) in the serodiagnosis of Schistosoma mansoni

Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages

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