2020
DOI: 10.32587/jnic.2020.00227
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Role of Cancer Emboli as a Metastatic Core on the Growth of Brain Metastasis in Patients with Non-Small Cell Lung Cancer

Abstract: Brain metastasis (BM) was a common complication of patient with non-small cell lung cancer (NSCLC) and associated with a poor prognosis. The study was to evaluate the effect of cerebral infarction (CI) which was originated from cancer emboli on the risk of BM in NSCLC for preventive therapy strategy. Methods Three hundred seven patients with newly diagnosed NSCLC in our institute from July 2013 to July 2018 were retrospectively analyzed. The diagnostic criteria of CI refereed to Updated Criteria for Population… Show more

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Cited by 3 publications
(2 citation statements)
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“…20 Neovascularization and rupture of the blood-brain barrier are potential consequences of cerebral infarction. 13,16 In the infarcted tissues, numerous capillary-sized blood vessels are surrounded by distended endothelial cells. 16 Experimental research suggests that neovascularization and hyperemia may be related.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…20 Neovascularization and rupture of the blood-brain barrier are potential consequences of cerebral infarction. 13,16 In the infarcted tissues, numerous capillary-sized blood vessels are surrounded by distended endothelial cells. 16 Experimental research suggests that neovascularization and hyperemia may be related.…”
Section: Discussionmentioning
confidence: 99%
“…12 The microenvironment can also be altered by an ischemic stroke, leading to neovascularization and blood-brain barrier leakage, which can function as a distinct risk factor for metastatic malignancies. 13 The brain and central nervous system (CNS) are particularly susceptible to melanoma spread, which results in significant morbidity and therapy resistance. 14 In patients with ischemic stroke and concurrent tumor, recent research has concentrated on the pathomechanisms and treatments for cancer-related stroke.…”
mentioning
confidence: 99%