Role of carbonic anhydrase II in ectopic calcification

Rajachar, Rupak M.; Tung, Elyse; Truong, Anh Q.; Look, Amy; Giachelli, Cecilia M.

doi:10.1016/j.carpath.2007.11.004

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…Thus, it is possible that CAVIII plays a role in forming the otic capsule and modiolus by modulating IP3‐induced Ca 2+ release during osteoblast differentiation. Although this hypothesis remains to be tested, Car8 expression in the differentiating otic capsule and modiolus is interesting because only Car1 and Car2 , which are expressed in bone marrow cells in otic capsule, have been known as major carbonic anhydrases associated with bone development (Lehenkari et al, ; Rajachar et al, ).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Survey of Carbonic Anhydrase mRNA Expression During Mammalian Inner Ear Development

Sagong

Choi

et al. 2013

Developmental Dynamics

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Background: Carbonic anhydrases (CAs), which catalyze CO 2 hydration to bicarbonate and protons, have been suggested to regulate potassium homeostasis and endocochlear potential in the mammalian cochlea. Sixteen mammalian CA isozymes are currently known. To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development. Results: Our quantitative reverse transcriptase-polymerase chain reaction results showed that different tissues express unique combinations of CA isozymes. During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes. Spatial expression patterns of these isozymes within developing inner ears were determined by in situ hybridization. Each isozyme showed a unique expression pattern during development. For example, Car12 and Car13 expression closely overlapped with Pendrin, an anion exchanger, while Car2 overlapped with Na-K-ATPase in type II and IV otic fibrocytes, suggesting functional relationships in the inner ear. Conclusions: The temporal and spatial expression patterns of each CA isozyme suggest unique and differential roles in inner ear development and function. Developmental Dynamics 242:269-280, 2013. V C 2012 Wiley Periodicals, Inc.Key words: carbonic anhydrase; inner ear; cochlea; mouse; development Key findings:A systematic survey for transcripts of all 16 mammalian carbonic anhydrase isozymes in various organs showed that each organ expresses unique combinations of carbonic anhydrase isozymes. During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes. Each isozyme showed a unique temporal and spatial expression pattern during inner ear development. Expression patterns for some isozymes closely overlapped with genes previously associated with inner ear development or function, such as Pendrin, Pou3f4, or Bmp4.

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Section: Resultsmentioning

confidence: 99%

A Systematic Survey of Carbonic Anhydrase mRNA Expression During Mammalian Inner Ear Development

Sagong

Choi

et al. 2013

Developmental Dynamics

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“…The ability of OPN to inhibit bioprosthetic valve calcification depends on its ability to bind to nascent mineral deposits via phosphorylated serine and threonine residues, thus blocking crystal growth (Jono et al, 2000). OPN also promotes RGD‐dependent cell interactions that lead to increased carbonic anhydrase expression and mineral regression (Rajachar et al, 2009; Steitz et al, 2002).…”

Section: Approaches To Diminish or Control The Fbrmentioning

confidence: 99%

Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts

Bryers

Giachelli

Ratner

2012

Biotech & Bioengineering

Self Cite

243

294

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This article focuses on one of the major failure routes of implanted medical devices, the foreign body reaction (FBR)—that is, the phagocytic attack and encapsulation by the body of the so-called “biocompatible” biomaterials comprising the devices. We then review strategies currently under development that might lead to biomaterial constructs that will harmoniously heal and integrate into the body. We discuss in detail emerging strategies to inhibit the FBR by engineering biomaterials that elicit more biologically pertinent responses.

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“…Carbonic anhydrase, an enzyme that regulates ectopic calcification (64), as occurs in many AAA patients, may also serve as an autoantigen. In a proteomic survey of AAA walls by Ando et al (3), carbonic anhydrase 1 (CA1) was identified as a candidate autoantigen.…”

Section: Putative Autoantigens In Aaa Tissuementioning

confidence: 99%

Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms

Chang

Gracon

Murphy

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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The abdominal aortic aneurysm (AAA) is a disease process that carries significant morbidity and mortality in the absence of early identification and treatment. While current management includes surveillance and surgical treatment of low- and high-risk aneurysms, respectively, our narrow understanding of the pathophysiology of AAAs limits our ability to more effectively manage and perhaps even prevent the occurrence of this highly morbid disease. Over the past couple of decades, there has been considerable interest in exploring the role of autoimmunity as an etiological component of AAA. This review covers the current literature pertaining to this immunological process, focusing on research that highlights the local and systemic immune components found in both human patients and murine models. A better understanding of the autoimmune mechanisms in the pathogenesis of AAAs can pave the way to novel and improved treatment strategies in this patient population.

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Role of carbonic anhydrase II in ectopic calcification

Abstract: These results indicate that CAR2 expression is an important regulator of ectopic calcification, potentially by facilitating OPN mediated mineral regression.

Cited by 14 publications

References 22 publications

A Systematic Survey of Carbonic Anhydrase mRNA Expression During Mammalian Inner Ear Development

A Systematic Survey of Carbonic Anhydrase mRNA Expression During Mammalian Inner Ear Development

Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts

Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms

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