Role of carboprost in prevention of postpartum hemorrhage

Lamba, Akanksha; Joshi, Godawari; Gupta, Madhulika B.

doi:10.18203/2320-1770.ijrcog20162082

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Everyday about 1500 women dies from pregnancy and child birth related complications. 6 The primary aim in the management of PPH should be its prevention. Active management of the third stage with routine prophylactic administration of oxytocics at the time of delivery of the anterior shoulder of the fetus has been shown to reduce the risk of postpartum hemorrhage by about 40 %.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of efficacy of intramuscular PGF2alpha and intramuscular oxytocin in management of third stage of labour

Agarwal,

Meena,

Sushma

2023

Int J Reprod Contracept Obstet Gynecol

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Background: The third stage of labour is most crutial stage begins with expulsion of baby and end with expulsion of placenta and membranes. The present study was conducted to evaluate the scope of using prophylactic intramuscular carboprost tromethamine in comparison with intramuscular oxytocin for active management of third stage of labor. Methods: Patients were divided randomly into 2 groups 39 in each group. Patients assigned to group 1 received 10 units oxytocin IM and group 2 received carboprost 125 µg IM after delivery of anterior shoulder of baby. The main outcomes measured were duration of third stage of labor, mean amount of blood loss, additional oxytocic requirement, HB changes in group and side effects of drug which were used in each group. Results: Subjects who received carboprost showed a significant reduction in duration of third stage of labor (P= 0.041), amount of blood loss (P=0.046) and requirement of additional oxytocic compared to the subject who received oxytocin 10 units. Conclusions: Carboprost 125µg is better alternative compared to injection 10 units oxytocin in the prophylactic management of third stage of labor.

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Section: Discussionmentioning

confidence: 99%

A comparative study of efficacy of intramuscular PGF2alpha and intramuscular oxytocin in management of third stage of labour

Agarwal,

Meena,

Sushma

2023

Int J Reprod Contracept Obstet Gynecol

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“…Postpartum hemorrhage is one of the most important cause of maternal death throughout the world. Everyday about 1500 women dies from pregnancy and child birth related complications [7] . Active management of third stage of labour and use of prophylactic oxytocin has reduced its incidence in many countries.…”

Section: Discussionmentioning

confidence: 99%

Comparison of carboprost with oxytocin in third stage of labour

Madhulika¹,

Singh²,

Rai³

2019

Int. J. Clin. Obstet. Gynaecol.

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Background: The third stage of labour commences with the complete delivery of the foetus and ends with the complete delivery of the placenta and its attached membranes. The present study was conducted to evaluate the scope of using carboprost in comparison with intramuscular oxytocin and providing single drug for third stage of labour which is effective as well as safe and associated with less side effects. Materials & Methods:The present study was conducted on 220 females. Patients were randomly assigned into two equal groups. Third stage of labour was observed for sign of placental separation such as uterine tone, symphysis fundal height, lengthening of cord and gush of blood. Results: Group 1 women received (10 Unit) oxytocin and group II women received (125 micrograms) carboprost. Each group had 110 patients. The mean maternal age in oxytocin group was 26.23+4.16 years and in carboprost group was 25.51+3.98 years. The mean duration of third stage of labour was 8.77+3.9 mins in oxytocin group and 7.59+3.9 mins in carboprost group. The difference was found to be statistically significant. In group I, mean blood loss was 264.69 ml and in group II was 175.15 ml. Conclusion:Carboprost is better and cost effective alternative to intramuscular 10 units oxytocin in the prophylactic management of third stage of labor. Carboprost reduces the duration of third stage, amount of blood loss, decreases the requirements of additional oxytocin.

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Role of carboprost in prevention of postpartum hemorrhage

Cited by 2 publications

References 4 publications

A comparative study of efficacy of intramuscular PGF2alpha and intramuscular oxytocin in management of third stage of labour

A comparative study of efficacy of intramuscular PGF2alpha and intramuscular oxytocin in management of third stage of labour

Comparison of carboprost with oxytocin in third stage of labour

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