Role of carotid body in pressure response of pulmonary circulation in rats

Sugito, Kazutoshi; Igari, Hidetoshi; Kasahara, Yasunori; Tani, Toshiaki; Kimura, Hiroshi; Hayashi, Fumiaki; Kuriyama, Takayuki

doi:10.1016/s0034-5687(97)00126-6

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Furthermore, NaCN significantly increased

{\dot V_{\rm{E}}}

(>200% increase) in dogs, which was driven by both f R and V T . A similar ventilatory responses to NaCN was also reported in rats (Sugito et al., 1998), rabbits (Matsumoto, 1986), cats (Berger, 1980), dogs (Alvarez‐Buylla & de Alvarez‐Buylla, 1988) and goat (Pan et al., 1998). It has been shown that NaCN‐dependent increase in

{\dot V_{\rm{E}}}

was mediated by the CBCs, as bilateral denervation of CSN (CSNx) attenuated the NaCN‐mediated ventilatory response (Koyama et al., 2000; Rodman et al., 2001).…”

Section: Discussionsupporting

confidence: 76%

Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs

Baby

Zaidi

Hunsberger³

et al. 2022

Experimental Physiology

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The carotid body chemoreceptors (CBC) play an important role in the adaptive counter-regulatory response to hypoglycaemia by evoking the CBC-mediated sympathetic neuronal system to restore normoglycaemia. Ex vivo studies have shown varied responses of insulin-induced hypoglycaemia on CBC function, and several in vivo studies have indirectly established the role of CBCs in restoring normoglycaemia in both animals and humans. However, a direct effect of insulin and/or insulin-induced hypoglycaemia on CBC activity is not established in animal models. Therefore, the aim of this study was to evaluate in vivo effects of insulin and insulin-induced hypoglycaemia on CBC activity and cardiorespiration in a preclinical large animal model. The carotid sinus nerve (CSN) activity and cardiorespiratory responses to sodium cyanide (NaCN; 25 µg/kg) were compared before (euglycaemic) and after (hypoglycaemic) intracarotid administration of insulin (12.5-100 µU/dogs) in beagle dogs. Insulin administration increased CSN activity and minute ventilation ( VE ) with significant (P < 0.0001) effects on heart rate and blood pressure. Insulin-mediated effects on CSN and cardiorespiration were sustained and the change in VE was driven by tidal volume only. Insulin significantly (P < 0.0001) lowered blood glucose level. NaCN-mediated CSN activity and VE were significantly (P < 0.0001) augmented during insulin-induced hypoglycaemia. The augmented VE was primarily driven by respiratory frequency and partially by tidal volume. The cardiovascular reflex response mediated through CBC stimulation was significantly (P < 0.0001) exacerbated during insulin-induced hypoglycaemia. Collectively, these results demonstrate direct effects of insulin and insulin-induced hypoglycaemia on CBC chemosensitivity to potentiate CBC-mediated neuroregulatory pathways to initiate adaptive neuroendocrine and cardiorespiratory counter-regulatory responses to restore normoglycaemia.

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“…Furthermore, NaCN significantly increased

{\dot V_{\rm{E}}}

{\dot V_{\rm{E}}}

was mediated by the CBCs, as bilateral denervation of CSN (CSNx) attenuated the NaCN‐mediated ventilatory response (Koyama et al., 2000; Rodman et al., 2001).…”

Section: Discussionsupporting

confidence: 76%

Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs

Baby

Zaidi

Hunsberger³

et al. 2022

Experimental Physiology

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“…K. Sugito и соавт. проводили эксперименты на крысах, оценивая влияние гипоксии каротидных телец одной из сонных артерий на состояние легочных артерий в остром эксперименте [12]. В условиях альвеолярной нормоксии крысам стимулировали каротидные тельца одной сонной артерии, вводя цианид натрия, вызывая местную тканевую гипоксию, и наблюдали значимое транзиторное повышение легочного артериального давления.…”

Section: Discussionunclassified

“…В этом случае уместен вопрос, насколько мощными должны быть афферентные сигналы для включения ответа через СНС. Некоторые результаты, полученные в остром эксперименте на крысах, показали, что активация каротидных телец даже одной наружной сонной артерии является достаточным стимулом для повышения тонуса легочных артерий [12]. При этом в литературе не описано долгосрочных влияний односторонней гипоксии каротидных телец на морфофункциональное состояние легочных артерий.…”

Section: вступлениеunclassified

Pulmonary hypertension in patients with hemodynamically significant atherosclerotic lesion of a common carotid artery: new pathophysiological mechanisms of the disease

et al. 2020

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Background. Pulmonary hypertension (PH) is a severe pathology that often leads a patient to death or disability. Recently, the development of PH associated with activation of the sympathetic nervous system (SNS) has been of interest. Some results obtained in an acute experiment on rats showed that activation of the carotid bodies of one external carotid artery is a sufficient stimulus to increase the tone of pulmonary arteries. Obviously, this effect is mediated by the sympathetic nervous system. However, the long-term effects of unilateral hypoxia of the carotid bodies on the morphofunctional state of the pulmonary arteries are not described in the literature. Aim. Effect assessment of common carotid artery bifurcation region ischemia due to the atherosclerotic process on the pulmonary arteries in patients. Materials and methods. The retrospective study was conducted in the Burdenko Neurosurgical Center and in the National Medical Research Center for Cardiology. A total of 60 case histories were analyzed in detail. All patients underwent Duplex scanning of the brachiocephalic arteries, as well as transthoracic echocardiography. The study included patients with atherosclerotic plaque in the area of the common carotid artery bifurcation on either one side or both. Exclusion criteria consisted of diseases that lead to the development of PH. The relationship between the presence of hemodynamically significant atheroma and the development of PH was evaluated. Results. Patients were divided into two groups those with hemodynamically significant atherosclerotic plaque in the common carotid artery bifurcation region at least on one side (more than 75% of the vascular obstruction) and hemodynamically insignificant atheromas in the common carotid artery bifurcation region on one or both sides (less than 45%). Among patients from the first group, 52.8% of the patients had signs of PH. Among patients from the second group, only 16.7% of the patients had signs of PH. The difference in the frequency of PH occurrence between the two selected groups is statistically significant (p=0.005). There were no differences in red blood cells number, platelets number, glucose concentration and lipid composition of blood plasma. Conclusion. Activation of SNS due to hemodynamically significant atherosclerotic plaque in the area of the bifurcation of the common carotid artery may be an independent mechanism for the development of PH. Key words: pulmonary hypertension, carotid bodies, atherosclerotic plaque, sympathectomy of pulmonary arteries.

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Potential Contribution of Carotid Body-Induced Sympathetic and Renin-Angiotensin System Overflow to Pulmonary Hypertension in Intermittent Hypoxia

Iturriaga

Castillo-Galán

2019

Curr Hypertens Rep

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Role of carotid body in pressure response of pulmonary circulation in rats

Cited by 6 publications

References 12 publications

Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs

Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs

Pulmonary hypertension in patients with hemodynamically significant atherosclerotic lesion of a common carotid artery: new pathophysiological mechanisms of the disease

Potential Contribution of Carotid Body-Induced Sympathetic and Renin-Angiotensin System Overflow to Pulmonary Hypertension in Intermittent Hypoxia

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