Role of catecholamines in maternal-fetal stress transfer in sheep

Rakers, Florian; Bischoff, Sabine; Schiffner, René; Haase, Michelle; Rupprecht, Sven; Kiehntopf, Michael; Kühn‐Velten, W. Nikolaus; Schubert, Harald; Witte, Otto W.; Nijland, Mark J.; Nathanielsz, Peter W.; Schwab, Matthias

doi:10.1016/j.ajog.2015.07.020

Cited by 39 publications

(30 citation statements)

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“…Although a high concentration of circulating glucocorticoids in the fetus is expected if chronic maternal stress is present, negative feedback mechanisms can prevent sustained high fetal concentrations of glucocorticoids. In this context, some authors have suggested that high levels of fetal catecholamines are the main effectors of the relationship between maternal stress and restricted fetal growth . Catecholamines are proposed as primary mediators that maintain glucose levels in the fetus, resulting in decreased insulin, increased glucagon, and altered fetal phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…Catecholamines are proposed as primary mediators that maintain glucose levels in the fetus, resulting in decreased insulin, increased glucagon, and altered fetal phenotype. These changes lead to a favoring of neural cells and tissues, with greater anaerobic metabolism in peripheral and skeletal tissues, and consequently restricted growth and increased lactate …”

Section: Discussionmentioning

confidence: 99%

“…In this context, some authors have suggested that high levels of fetal catecholamines are the main effectors of the relationship between maternal stress and restricted fetal growth. 22,23 Catecholamines are proposed as primary mediators that maintain glucose levels in the fetus, resulting in decreased insulin, increased Variables were modeled in continuous (age and education) or ordinal (environmental score) form, but are shown as logical categories to better observe the profile of the study population, and to facilitate a calculation of conditional probabilities of IUGR by subgroup (P values were obtained by using continuous and ordinal variables, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…These changes lead to a favoring of neural cells and tissues, with greater anaerobic metabolism in peripheral and skeletal tissues, and consequently restricted growth and increased lactate. 22,23 The study has both strengths and limitations. Because information on IUGR was obtained from routine medical records about gestational age and birthweight, the findings should be re-evaluated using gold standard measures.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Psychologic intimate partner violence and the risk of intrauterine growth restriction in Rio de Janeiro

Lobato

Reichenheim

Moraes

et al. 2017

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Psychologic intimate partner violence and the risk of intrauterine growth restriction in Rio de Janeiro

Lobato

Reichenheim

Moraes

et al. 2017

Intl J Gynecology & Obste

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“…Experimental animal studies and natural experiments in humans suggest that prenatal exposure to maternal anxiety can elicit modulation of “ developmental programming ” in the offspring (Bock, Wainstock, Braun, & Segal, ; Daskalakis, Bagot, Parker, Vinkers, & de Kloet, ; de Kloet, Joels, & Holsboer, ; Laplante, Brunet, Schmitz, Ciampi, & King, ). Although potentially underlying mechanisms are not fully understood, it has frequently been proposed that maternal anxiety leads to increased production of maternal stress hormones (e.g., cortisol, noradrenaline) and down‐regulation of the placental 11β‐HSD2 enzyme that metabolizes maternal cortisol into inactive cortisone (O'Donnell et al., ; Rakers et al., ). This may result in increased levels of cortisol in the fetal circulation, which together with other processes such as inflammation (Christian, ) and neuro‐inflammation (Hanamsagar & Bilbo, ; Labouesse, Langhans, & Meyer, ) may elicit long‐term changes in structure and function of the developing brain via epigenetic pathways (Bock et al., ; Monk, Spicer, & Champagne, ; Van den Bergh, ).…”

Section: Introductionmentioning

confidence: 99%

Children prenatally exposed to maternal anxiety devote more attentional resources to neutral pictures

Heuvel

Henrichs

Donkers

et al. 2017

Developmental Science

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Maternal anxiety during pregnancy can negatively affect fetal neurodevelopment, predisposing the offspring to a higher risk of behavioral and emotional problems later in life. The current study investigates the association between maternal anxiety during pregnancy and child affective picture processing using event-related brain potentials (ERPs). Mothers reported anxiety during the second trimester using the anxiety subscale of the Symptom Checklist (SCL-90). At age 4 years, child affective picture processing (N = 86) was measured by recording ERPs during viewing of neutral, pleasant, and unpleasant pictures selected from the International Affective Pictures System. The late positive potential (LPP)-an ERP component reflecting individual differences in affective processing-was used as child outcome. The expected positive association between maternal anxiety and LPP amplitude for unpleasant pictures was not found. Nevertheless, we found a positive association between maternal anxiety during pregnancy and LPP amplitudes for neutral pictures in the middle and late time window at anterior locations (all p < .05). These associations remained significant after adjusting for maternal postnatal anxiety and gestational age at birth and after FDR correction for multiple comparisons. Our study provides neurophysiological evidence that children prenatally exposed to higher maternal anxiety devote more attentional resources to neutral pictures, but not to unpleasant pictures. Possibly, these children show enhanced vigilance for threat when viewing neutral pictures. Although useful in dangerous environments, this enhanced vigilance may predispose children prenatally exposed to higher maternal anxiety to developing behavioral and/or emotional problems later in life. A video abstract of this article can be viewed at: https://www.youtube.com/watch?v=kEzYi6IS2HA.

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Maternal Prenatal Depressive Symptoms and Fetal Growth During the Critical Rapid Growth Stage

Zhang,

Li,

et al. 2023

JAMA Netw Open

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ImportanceFetal growth in the critical rapid growth stage (CRGS) before delivery, approximately between 30 to 37 gestational weeks, carries significant implications for subsequent overweight, obesity, and arterial health. Previous evidence has demonstrated the association between maternal depressive symptoms and fetal growth trajectories from early to late pregnancy, but there remains limited understanding of the association of these symptoms with the longitudinal fetal growth change within the CRGS.ObjectiveTo investigate the association between maternal depressive symptoms and fetal growth during the CRGS before delivery.Design, Setting, and ParticipantsThis prospective birth cohort study was conducted from January 2018 to December 2020. Volunteer pregnant women were enrolled in their first trimester of prenatal visits. Women with severe disease before pregnancy and multiple births, fetuses with congenital anomalies, and preterm or postterm births were excluded. This multicenter study was based in 13 hospitals covering 81 counties across 12 cities in Sichuan Province, China. Follow-up visits were performed at the second trimester, the third trimester, and 24 hours after delivery. The analysis was conducted from January to May 2023.ExposuresMaternal depressive symptoms, as a continuous variable, measured by the Edinburgh Postpartum Depression Scale (EPDS) at a median gestational week of 24 (range, 14 to 27) weeks of gestation. A higher score on the EPDS indicates worse depressive symptoms.Main Outcomes and MeasuresThe main outcomes included ultrasonography-measured biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC), along with calculated estimated fetal weight (EFW). These parameters were evaluated longitudinally at a median gestational week of 30 (range, 28 to 32) and 37 (range, 35 to 39) weeks. Linear mixed models were used to estimate the associations between maternal depressive symptoms and fetal growth parameters.ResultsA total of 2676 mother-offspring dyads were included, in which the mean (SD) age of mothers was 28.0 (4.4) years, and 1294 (48.4%) of the offspring were female. The median (IQR) maternal EPDS score was 5.0 (4.0 to 9.0). After adjustment for confounders, a significant correlation was found between a higher score of depressive symptoms in mothers and a slower rate of fetal growth across FL (β = −0.40; 95% CI, −0.58 to −0.22), AC (β = −1.97; 95% CI, −2.90 to −1.03), and EFW (β = −50.11; 95% CI, −68.46 to −31.75). These associations were stronger in female fetuses or those with better family socioeconomic conditions.Conclusions and RelevanceIn this prospective cohort study, maternal depressive symptoms were associated with slower fetal growth rate in the CRGS before delivery. Early screening for depressive disorders in pregnant women appears to be essential for fetal growth and later health.

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Role of catecholamines in maternal-fetal stress transfer in sheep

Cited by 39 publications

References 38 publications

Psychologic intimate partner violence and the risk of intrauterine growth restriction in Rio de Janeiro

Psychologic intimate partner violence and the risk of intrauterine growth restriction in Rio de Janeiro

Children prenatally exposed to maternal anxiety devote more attentional resources to neutral pictures

Maternal Prenatal Depressive Symptoms and Fetal Growth During the Critical Rapid Growth Stage

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