Role of catecholamines in the anorectic effects of amphetamine in rats

Baez, Luis A.

doi:10.1007/bf00429576

Cited by 60 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He suggests that catecholamines act on these centers in order to induce anorexia. Baez (1974) concurs indicating that the data points strongly to the involvement of brain catecholamines in the depression of food intake with dopamine-containing neurons playing the major role. The possibility that dopamine plays a major role in producing anorexia is enhanced by the observation of Barzaghi et al (1973) who described a reduction of food intake mediated by apomorphine.…”

Section: Virginia C Barry and H L Ktawans"supporting

confidence: 68%

On the role of dopamine in the pathophysiology of anorexia nervosa

Barry¹,

Klawans

1976

J. Neural Transmission

127

View full text Add to dashboard Cite

Based on a review of the pathophysiology of the major symptoms of anorexia nervosa, it was suggested that increased activity of dopamine at central dopamine receptors plays a role in the pathophysiology of this disorder. Although dopamine receptor site hypersensitivity, or synthesis, of a false transmitter could account for this, a defect in negative feedback control mechanisms is more consistent with the known characteristics of anorexia nervosa. The possible role of pure dopamine antagonists in symptomatic treatment and of dopamine agonists in reversing this disorder was discussed.

show abstract

Section: Virginia C Barry and H L Ktawans"supporting

confidence: 68%

On the role of dopamine in the pathophysiology of anorexia nervosa

Barry¹,

Klawans

1976

J. Neural Transmission

127

View full text Add to dashboard Cite

show abstract

“…It has been noted earlier that the ratio of the potencies of d-and I-amphetamine for suppressing the onset of hoarding was 2: 1. Significantly, it has been suggested that potency ratios of this order indicate dopaminergic mediation of drug action (e.g., Baez, 1974;Taylor & Snyder, 1971). In order to investigate the possibility that a dopaminergic mechanism may be involved in the initiation of hoarding, the following experiment examined the effect of hoarding of a dopamine blocking agent with fairly specific action-pimozide (Anden, Butcher, Corrodi, Fuxe, & Ungerstedt, 1970).…”

Section: Resultsmentioning

confidence: 99%

“…Current explanations favor a role for brain catecholamines in feeding (e.g., Grossman, 1975;Mogenson, 1974), and although intrahypothalamic injections of norepinephrine which induce feeding failed to initiate hoarding activity , other studies have reported that injections of amphetamine reduce both feeding and hoarding (Blundell, 1971;Zucker & Milner, 1964). Since the effects of amphetamine on feeding may be largely mediated via catecholamine mechanisms (e.g., Baez, 1974;Carey & Goodall, 1975;Holtzman & Jewett, 1971. ), these B. J. Strupp is now at Psychology Department, Cornell University.…”

mentioning

confidence: 99%

Pharmacological manipulation of hoarding: Further analysis of amphetamine isomers and pimozide

1977

View full text Add to dashboard Cite

Dose-response relationships were established for the effect of d-and I-amphetamine on hoarding latency, the time course of hoarding, and the size of the total hoard. Both isomers displayed a marked effect on hoarding latency with the d isomer approximately twice as potent as the I form. The effects of the isomers on latency were reflected in the temporal profiles and in the sizes of the accumulated hoards. In a further experiment, pimozide-a dopamine blocking agent-drastically reduced the overall level of hoarding but had only a minor effect on hoarding latency. Pimozide exerted selective action on the amphetamine isomers, markedly antagonizing the effect of d-amphetamine on latency but displaying little effect on the I form. The results indicate that pharmacological manipulation can reduce hoarding activity in the rat by means of a number of distinct mechanisms.

show abstract

“…is enough to suppress feeding and does not induce an aversive response in the taste reactivity test (Wellman & Peters, 1980). It is well known that the anorexic action of amphetamine is linked to the activation of dopamine receptors and/or β‐adrenoceptors by amphetamine within the lateral hypothalamus (Booth, 1968; Baze, 1974; Leibowitz, 1975). Amphetamine anorexia is prevented by pretreatment with dopamine antagonists (Baze, 1974; Wellman, 1990b).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats

Doong¹,

Lu²,

Kau³

et al. 1998

British J Pharmacology

View full text Add to dashboard Cite

1 The e ect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2 Gastric emptying was inhibited both acutely and chronically by the administration of amphetamine. GI transit was decreased by the acute administration of amphetamine but not a ected by the chronic administration of amphetamine. 3 Plasma CCK levels were increased dose-dependently by amphetamine. 4 Proglumide, a CCK receptor antagonist, prevented amphetamine-induced inhibition of gastric emptying and the decrease in GI transit in male rats. 5 The selective CCK A receptor antagonist, lorglumide, dose-dependently attenuated the amphetamineinduced inhibition of gastric emptying in male rats. In contrast, the selective CCK B receptor antagonist, PD 135,158, did not reverse the e ect of amphetamine on gastric emptying. 6 Both lorglumide and PD 135,158 reversed the inhibitory e ect of amphetamine on GI transit in male rats. 7 These results suggest that amphetamine-induced inhibition of gastric emptying and intestinal transit is due in part to a mechanism associated with the hypersecretion of endogenous CCK.

show abstract

Role of catecholamines in the anorectic effects of amphetamine in rats

Cited by 60 publications

References 20 publications

On the role of dopamine in the pathophysiology of anorexia nervosa

On the role of dopamine in the pathophysiology of anorexia nervosa

Pharmacological manipulation of hoarding: Further analysis of amphetamine isomers and pimozide

Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats

Contact Info

Product

Resources

About