Role of cathepsin L in idiopathic nephrotic syndrome in children

Sugimoto, Kunihisa; Miyazaki, Katsumi; Enya, Takuji; Miyazawa, Tomoki; Morimoto, Yuichi; Oshima, Rina; Takemura, Tamiko; Okada, Minoru

doi:10.1016/j.mehy.2020.109718

Cited by 6 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Captesin L is believed to promote proteolysis of CD2-associated protein (Cd2ap) and synaptopodin. Furthermore, it leads to dynamic cleavage at an evolutionarily conserved site, resulting in reorganization of the podocyte actin cytoskeleton [20,21]. Other type of cathepsin that has been linked to glomerular pathologies is cathepsin D, it is an aspartic protease, which is important to maintain the integrity of podocytes, since mice deficient in cathepsin D develop cleavage diaphragm fragmentation, proteinuria and end-stage renal disease.…”

Section: Intracellular Proteasesmentioning

confidence: 99%

The Interaction of Podocytes, Glomerular Cells and Mesangial Cells in Glomerulopathies

Calvo

2021

AJBSR

View full text Add to dashboard Cite

Compared to primary glomerulopathies, secondary glomerulopathies refer to those in which glomerular damage is part of a complex clinical picture, caused by different processes: immunological, tumors, hereditary, infections or drugs, the classic examples are triggered by the systemic lupus erythematosus (SLE), diabetes, among others See Tables 1&2 [4]. During years, glomerulopathies have been closely related to chronic kidney disease (CKD) [5], occupying the first places of CKD triggers according to the 2017 report of the "The United States Renal Data

show abstract

Section: Intracellular Proteasesmentioning

confidence: 99%

The Interaction of Podocytes, Glomerular Cells and Mesangial Cells in Glomerulopathies

Calvo

2021

AJBSR

View full text Add to dashboard Cite

show abstract

“…Here we tested the hypothesis that overexpression of AAT lowers cathepsin B activity in the kidney leading to less proteolysis of ENaC and lower blood pressure. Cathepsins are known to cleave a myriad of proteins including actin cytoskeleton proteins that regulate membrane expression of transporters such as NCC and receptors such as NPRC in the kidney that contribute to electrolyte balance and blood pressure regulation ( Keisuke et al, 2020 ). Thus, we also investigated whether AAT overexpression could alter renal NCC and NPRC protein expression.…”

Section: Introductionmentioning

confidence: 99%

Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles

et al. 2021

View full text Add to dashboard Cite

Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about its targets in the aldosterone-sensitive distal nephron and its role in electrolyte balance and blood pressure control. We analyzed urinary electrolytes, osmolality, and blood pressure from hAAT transgenic (hAAT-Tg) mice and C57B/6 wild-type control mice maintained on either a normal salt or high salt diet. Urinary sodium, potassium, and chloride concentrations as well as urinary osmolality were lower in hAAT-Tg mice maintained on a high salt diet during both the active and inactive cycles. hAAT-Tg mice showed a lower systolic blood pressure compared to C57B6 mice when maintained on a normal salt diet but this was not observed when they were maintained on a high salt diet. Cathepsin B protein activity was less in hAAT-Tg mice compared to wild-type controls. Protein expression of the alpha subunit of the sodium epithelial channel (ENaC) alpha was also reduced in the hAAT-Tg mice. Natriuretic peptide receptor C (NPRC) protein expression in membrane fractions of the kidney cortex was reduced while circulating levels of atrial natriuretic peptide (ANP) were greater in hAAT-Tg mice compared to wild-type controls. This study characterizes the electrolyte and blood pressure phenotype of hAAT-Tg mice during the inactive and active cycles and investigates the mechanism by which ENaC activation is inhibited in part by a mechanism involving decreased cathepsin B activity and increased ANP levels in the systemic circulation.

show abstract

Parthenolide ameliorates tweak-induced podocytes injury

Zhang

Chen

et al. 2020

Mol Biol Rep

View full text Add to dashboard Cite

Role of cathepsin L in idiopathic nephrotic syndrome in children

Cited by 6 publications

References 31 publications

The Interaction of Podocytes, Glomerular Cells and Mesangial Cells in Glomerulopathies

The Interaction of Podocytes, Glomerular Cells and Mesangial Cells in Glomerulopathies

Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles

Parthenolide ameliorates tweak-induced podocytes injury

Contact Info

Product

Resources

About