Role of CBP/p300 and SRC-1 in Transcriptional Regulation of the Pulmonary Surfactant Protein-A (SP-A) Gene by Thyroid Transcription Factor-1 (TTF-1)

Yi, Ming; Tong, Guo Xia; Murry, Barbara A.; Mendelson, Carole R.

doi:10.1074/jbc.m109793200

Cited by 73 publications

(83 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intrafamilial phenotypic variation in this disorder may be explained by differences in modifier genes that produce a different genetic background in the same family. Indeed, the activity of TITF-1 is highly dependent on its interactions with other transcription factors and coactivators, including GATA-6, NF-1, RAR, CBP/p300, SRC-1, and TAZ [29][30][31][32][33][34]. In addition, deficient transcriptional activity of mutant TITF-1 (p.P202L) was completely rescued by cotransfection of wild-type PAX8 in HEK293 cells [13].…”

Section: Discussionmentioning

confidence: 94%

A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea

Nakamura¹,

Sekijima²,

Nagamatsu³

et al. 2012

Journal of the Neurological Sciences

View full text Add to dashboard Cite

A Japanese family with a novel nonsense mutation in the TITF-1 gene (p.Y98X) is described.The proband showed severe generalized chorea, delayed motor development, subnormal intelligence, congenital hypothyroidism, bronchial asthma, and a history of pulmonary infection, all of which are characteristic features of Brain-Thyroid-Lung syndrome. On the other hand, her brother and mother showed a mild benign hereditary chorea (BHC) phenotype with congenital hypothyroidism.Intrafamilial phenotypic variation is common in BHC/Brain-Thyroid-Lung syndrome and suggests the existence of other genetic or environmental factors regulating TITF-1 function. Although choreic movement in BHC/Brain-Thyroid-Lung syndrome is recognized as non-progressive, the proband showed re-exacerbation of choreic movement at puberty. The dopamine agonist, ropinirole hydrochloride, reduced her choreic movements, suggesting that levodopa and/or dopamine agonists may compensate for underdeveloped dopaminergic pathways in this disorder.BHC with a novel TITF-1 mutation 3

show abstract

Section: Discussionmentioning

confidence: 94%

A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea

Nakamura¹,

Sekijima²,

Nagamatsu³

et al. 2012

Journal of the Neurological Sciences

View full text Add to dashboard Cite

show abstract

“…For example, TTF-1 interacts with GATA6 to activate SP-C and Wnt7b transcription (47,67). Transcriptional co-activator TAZ and NFI interact with TTF-1 and synergistically activate the SP-C gene (65,68), whereas surfactant protein A and SP-B transcription is regulated by interaction of TTF-1 with CREB-binding protein and SRC-1 (66,69). TTF-1 also interacts with RAR/RXR and BR22 (66,70) to activate SP-B transcription.…”

Section: Discussionmentioning

confidence: 99%

Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells

Davé

Childs

Whitsett

2004

Journal of Biological Chemistry

View full text Add to dashboard Cite

“…SRC-3, also known as AIB1 (amplified in breast cancer), was reported originally in breast cancer in which gene amplification was occurred frequently and the expressions of SRC-3 were observed in several human tumors including breast cancer [2,5,6,9]. Temporal and spatial expressions of SRC-3 are coincident with CCSP expression pattern in the Clara cells of the lung [12] and in which CCSP could play an important role in the early lung development [22].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, TTF-1 could serve as a major regulator of CCSP gene expression [17,24], and it has been reported that TTF-1 could interact with the SRC [22]. Thus, TTF-1 might play important role in the lung development and lung tumor progression in combination with SRC-3.…”

Section: Introductionmentioning

confidence: 99%

Roles of Steroid Receptor Coactivator-3 and TTF-1 in Lung Development and Lung Cancer

Kwak¹

2015

Journal of Life Science

View full text Add to dashboard Cite

Steroid receptor coactivators (SRC) are transcriptional coactivators. Among SRCs, SRC-3 is the most studied in relation to different types of tumors. However, the role of SRC-3 in early lung development and lung cancer has not been well studied. The expression profiles of SRC-3 showed that SRC-3 contributed to bronchial and alveolar development in embryonic lung development. SRC-3 was strongly expressed in Clara cells and type II alveolar cells during fetal lung development (E17.5-E18.5), and SRC-3 was expressed in both cell types in the adult lung. TTF-1 was expressed in the lungs of heterozygote SRC-3 mice and Clara cell-specific-CCSP-TAg tumor mice, along with SRC-3 expression. The expression of TTF-1 was localized at transformed Clara cells and multifocal adenocarcinomas in lung cancer mice. However, SRC-3 was not expressed in the multifocal adenocarcinomas, suggesting that SRC-3 might not be involved in the invasiveness of lung cancer. Cotransfection of TTF-1 in Clara cell-specific mtCC cell lines resulted in significant activation of CCSP expression. However, cotransfection of SRC-3 had no significant effects on transient transfection. These in vivo and in vitro results suggest that SRC-3 does not play a significant role in lung tumor progression. In conclusion, SRC-3 is involved in bronchial and alveolar development in fetal and adult lungs, but it does not play an important role in the progression of Clara cell-derived lung cancer.

show abstract

Role of CBP/p300 and SRC-1 in Transcriptional Regulation of the Pulmonary Surfactant Protein-A (SP-A) Gene by Thyroid Transcription Factor-1 (TTF-1)

Abstract: Surfactant protein-A (SP-A

Cited by 73 publications

References 61 publications

A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea

A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea

Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells

Roles of Steroid Receptor Coactivator-3 and TTF-1 in Lung Development and Lung Cancer

Contact Info

Product

Resources

About