Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis

“…Fibrosis and aSMA-positive area were measured by an image analysis software (Dynamic Cell Count; Keyence, Osaka, Japan). The presence of F4/80-positive macrophages in epididymal fat tissue was detected immunohistochemically using the rat monoclonal anti-mouse F4/80 antibody kindly provided by Dr Motohiro Takeya (Kumamoto University) 39,40 . The number of F4/80-positive cells was counted in more than 10 mm 2 area of each section and expressed as the mean number per mm 2 .…”

Adipose tissue inflammation and ectopic lipid accumulation [Review]

“…MCP-1 is derived from both adipocytes and macrophages in adipose tissue [7,8]. MCP-1 and its cognate receptor C-C chemokine receptor 2 (CCR2) play a critical role in the recruitment of macrophages into obese adipose tissue, thereby aggravating adipose tissue inflammation [41][42][43][44]. It is also known that MCP-1 directly induces insulin resistance in the skeletal muscle and liver, suggesting a role of MCP-1 as an endocrine hormone [41,45].…”

CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children

“…The VFA was measured in cm 2 using DENSITY MASK software assuming a density of which is the co-occurrence of metabolic abnormalities including centrally distributed obesity, hypertensions, dyslipidemia and hyperglycemia. Ito et al showed that CC motif ligand 2 (CCL2, monocyte chemoattractant protein; MCP-1)/ CC motif receptor 2 (CCR2) pathway plays a role in macrophage infiltration into obese adipose tissue and obesity-related MS [12]. Previous studies [13][14][15] reported that the levels of CCL5 are elevated in obese adults with MS. Additionally, Faber et al reported that CXC motif chemokine 10 (CXCL10, interferon gamma-induced protein 10; IP-10) was related to VAT accumulation in adults [16].…”