Role of CD4:CD8 Ratio in Predicting HIV Co-infection in Patients with Newly Diagnosed Tuberculosis

Salazar, R; Souza, Victor Lima; Khan, Abdus Samad; Fleischman, Jean K.

doi:10.1089/108729100318000

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…HIV-negative patients with TB are expected to have higher CD4 cell counts than those who are HIV-positive. In one study, when the immunologic features of 54 patients with newly diagnosed TB with unknown HIV status were evaluated, the median CD4 and CD8 counts were statistically different between the HIV-seropositive and HIV-seronegative patients, with the median CD4/CD8 ratio being 0.17 in HIVseropositive patients and 1.95 in the HIV-seronegative patients (P Ͻ 0.0001) (10). In a similar recently published study from Pune, India, significant differences in the CD4 counts and CD4/CD8 ratios between HIV-seropositive and HIV-seronegative TB patients were found.…”

Section: Discussionmentioning

confidence: 99%

Comparison of CD4 and CD8 lymphocyte counts in HIV‐negative pulmonary TB patients with those in normal blood donors and the effect of antitubercular treatment: Hospital‐based flow cytometric study

Uppal

Tewari

Verma

et al. 2004

Cytometry Part B Clinical

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Background: This study was designed to flow cytometrically determine baseline and sequential values of CD4 and CD8 lymphocyte subsets in patients without the human immunodeficiency virus and with pulmonary tuberculosis (TB) and to correlate these values with those obtained from normal male blood donors and with the radiologic extent of disease and response to therapy.Methods: We studied 39 male patients without the human immunodeficiency virus and with sputum positive for pulmonary TB who had been admitted to Military Hospital (Cardiothoracic Center) in Pune, India. Clinical, laboratory, and radiologic evaluations of these patients were done. Hematologic parameters were assessed by an automated hematology cell counter (AcT*Diff, Coulter), and T-cell subsets (CD4 and CD8) were determined flow cytometrically (EPICS-XL, Coulter).Results: CD4 counts and percentages of CD4 were significantly lower, but CD8 values were normal, in patients with pulmonary TB when compared with values obtained in normal blood donors. The CD4/CD8 ratio was significantly lower in patients with TB. The CD4 counts normalized with antitubercular treatment. The radiologic extent of disease did not correlate well with the immune parameters studied.Conclusions: TB is a reversible cause of CD4 lymphocytopenia and is associated with normal numbers of CD8 cells. The radiologic extent of disease does not seem to determine the immune response.

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Section: Discussionmentioning

confidence: 99%

Comparison of CD4 and CD8 lymphocyte counts in HIV‐negative pulmonary TB patients with those in normal blood donors and the effect of antitubercular treatment: Hospital‐based flow cytometric study

Uppal

Tewari

Verma

et al. 2004

Cytometry Part B Clinical

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“…However, it has been documented that there is significant role of CD4: CD8 ratio in predicting HIV co-infection in newly diagnosed TB. 8 It has been suggested that TB patients have a microenvironment that facilitates HIV infection by i) increasing the expression of co-receptors CXCR4 and CCR5 regulated by M. tuberculosis products; ii) increasing pro-inflammatory cytokines, especially TNF; and iii) down-regulation of CCL5. It has also been shown that M. tuberculosis and its cell wall component, lipoarabinomannan (LAM) may activate replication of HIV in provirus-carrying cells by inducing TNF and IL-6 production through the NF-kB pathway, which in turn triggers transcriptional activation of the long terminal repeat (LTR) promoter and supports replication of HIV.…”

Section: Introductionmentioning

confidence: 99%

Comparison of CD4 and CD8 counts and ratio in HIV negative pulmonary tuberculosis patients with normal healthy controls

Sabhapandit¹,

Hazarika²,

Phukan³

et al. 2017

Int J Res Med Sci

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Background: There is an equivocal contention that Tuberculosis may be a cause of non-HIV-associated CD4+ T cell lymphopenia. In HIV negative patients, CD4+ and CD8+ T cell count suppression has been associated with TB infection. Prediction of HIV coinfection in newly diagnosed pulmonary TB patients with negative HIV status by estimation of CD4, CD8 count and CD4:CD8 ratio.Methods: Newly diagnosed pulmonary TB patients comprising of 30 numbers with negative HIV status were subjected for estimation of CD4, CD8 counts and ratio for prediction of HIV coinfection. Equal number of healthy controls was also included in the study for comparison of the values.Results: Significantly lower CD4 and CD8 counts among pulmonary TB infected HIV negative patients as compared with healthy controls was found. The CD4:CD8 ratio was normal when compared with healthy controls.Conclusions: The present study highlights the importance of estimation of CD4+ and CD8+ T cell counts and ratio in newly diagnosed pulmonary TB patients with negative HIV status. Prediction ability in combination with early detection and appropriate management play major role in evading emergence of drug resistance among the HIV-TB coinfected patients.

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“…In human, Salazar et al . [19] reported that the CD4:CD8 ratio was a useful parameter in predicting HIV-TB co-infection. In swine, a specific feature is that a substantial number of both CD4-CD8- and CD4+CD8+ T cells were found in peripheral blood [15,20-24].…”

Section: Introductionmentioning

confidence: 99%

Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine

et al. 2011

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BackgroundIncreased disease resistance through improved general immune capacity would be beneficial for the welfare and productivity of farm animals. T lymphocyte subpopulations in peripheral blood play an important role in immune capacity and disease resistance in animals. However, very little research to date has focused on quantitative trait loci (QTL) for T lymphocyte subpopulations in peripheral blood in swine.ResultsIn the study, experimental animals consist of 446 piglets from three different breed populations. To identify QTL for T lymphocyte subpopulations in peripheral blood in swine, the proportions of CD4+, CD8+, CD4+CD8+, CD4+CD8-, CD4-CD8+, and CD4-CD8- T cells and the ratio of CD4+:CD8+ T cells were measured for all individuals before and after challenge with modified live CSF (classical swine fever) vaccine. Based on the combined data of individuals from three breed populations, genome-wide scanning of QTL for these traits was performed based on a variance component model, and the genome wide significance level for declaring QTL was determined via permutation tests as well as FDR (false discovery rate) correction. A total of 27 QTL (two for CD4+CD8+, one for CD4+CD8-, three for CD4-CD8+, two for CD4-CD8-, nine for CD4+, two for CD8+, and eight for CD4+:CD8+ ratio) were identified with significance level of FDR < 0.10, of which 11 were significant at the level of FDR < 0.05, including the five significant at FDR < 0.01.ConclusionsWithin these QTL regions, a number of known genes having potential relationships with the studied traits may serve as candidate genes for these traits. Our findings herein are helpful for identification of the causal genes underlying these immune-related trait and selection for immune capacity of individuals in swine breeding in the future.

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Role of CD4:CD8 Ratio in Predicting HIV Co-infection in Patients with Newly Diagnosed Tuberculosis

Cited by 6 publications

References 17 publications

Comparison of CD4 and CD8 lymphocyte counts in HIV‐negative pulmonary TB patients with those in normal blood donors and the effect of antitubercular treatment: Hospital‐based flow cytometric study

Comparison of CD4 and CD8 lymphocyte counts in HIV‐negative pulmonary TB patients with those in normal blood donors and the effect of antitubercular treatment: Hospital‐based flow cytometric study

Comparison of CD4 and CD8 counts and ratio in HIV negative pulmonary tuberculosis patients with normal healthy controls

Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine

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