Role of Cell Block in Diagnostics-A New Paradigm in Cancer Diagnosis

Sharma, Ram Babu

doi:10.15406/icpjl.2015.01.00025

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…Amongst the Fine needle aspirates maximum cases were from lymph nodes (43.5%) followed by 4 (2%) from breast, 4 (2%) from scalp, 5 (2.7%) from skin (2 from cheek and 3 abdominal wall), 3 (1.5%) from soft tissue (1 each from arm, foot and sternum) and 1 (0.5%) from mandible bone. Sharma R et al 12 also reported a greater frequency of FNA from lymph node followed by breast. Out of the 85 cases of lymph node FNAC, majority of the positive FNAC cases were performed on cervical neck nodes and metastatic squamous cell carcinoma comprised majority of the diagnosis.…”

Section: Discussionmentioning

confidence: 94%

The diagnostic utility of cell block as an adjunct to routine cytology

Pathak,

Rhutso,

Ahmed

2024

ACHR

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Despite the diagnostic utility of cell block in FNAC and fluid cytology, known for better cellular yield and improved diagnostic accuracy, the technique remains to be underutilized for diagnosing neoplastic lesions.In this paper, a hospital based prospective study of 195 samples was conducted on cytological samples with the aim (a) to evaluate the diagnostic utility of cell block as an adjunct to routine cytological evaluation of aspiration and effusion fluid specimens, (b) To correlate the findings of routine cytology, cell block and routine histopathological examination wherever possible and (c) to explore the possibility of using ancillary techniques such as immunohistochemistry on cell blocks. The study revealed, most of the patients were between 51- 60 years with female preponderance. Among 195 samples, 79 (40.5%) were peritoneal fluids and 85 (43.5%) were lymph node. The diagnosis on conventional smear and cell block showed 71 (36.5%) cases and 68 (35%) cases were negative for malignancy respectively. 6 (3%) cases and 4 (2%) cases were suspicious for malignancy respectively. 118 (60.5%) cases and 123 (63%) cases were positive for malignancy respectively. Amongst the peritoneal effusion the most common primary site was ovary whereas majority of the primary site was unknown in lymph node FNAC. Peritoneal effusion showed 8 additional cases as positive for malignancy in CB preparation which were negative or suspicious for malignancy on CS. In FNAC, two additional positive case was found in CB preparation of lymph node. A Kappa value of 89.5 % for statistical correlation between Conventional smear and cell block preparation was calculated. The use of Cell block technique increases the detection of malignancy when used as an adjunct to conventional smears. Cell block technique is simple, inexpensive and reliable adjuvant to smears and it is recommended for routine cytological diagnosis and for application of immunomarkers and molecular studies.

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Section: Discussionmentioning

confidence: 94%

The diagnostic utility of cell block as an adjunct to routine cytology

Pathak,

Rhutso,

Ahmed

2024

ACHR

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“…Kern and Heber also got additional diagnostic information by the application of cell block in 60.3% of cases (18); thus, helping in the conclusive diagnosis. Sharma et al, (19) showed that cell blocks improved the efficacy of cytodiagnosis, particularly for malignant and suspicious cases. They also showed that immunomarkers could be reliably reported on cell blocks in 94.7% of the cases.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Cell Block Method and Smear Cytology in Fine Needle Aspiration Cytology of Intra-abdominal Mass Lesions

Bhowmik

Chakrabarti²,

Ghosh

et al. 2018

Iran J Pathol

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Fine Needle AspirationCytology; Cell BlockBackground & objective: Fine needle aspiration cytology (FNAC) is an easy, rapid, and less hazardous tool to diagnose the intra-abdominal lesions with various imaging modalities adding to its sensitivity and accuracy. However, sometimes it does not yield adequate information for precise diagnosis and the risk of false-negative and indeterminate diagnosis is always present. Cellblock preparations may be particularly helpful in such problematic cases.The current study aimed atevaluating and comparing the cytological as well as histopathological features of different intra-abdominal mass lesions.Methods: Image-guided FNAC followed by cell block were performed on 167 patients from June 2012 to May 2013. Histologically correlated 111 cases were evaluated. Results of conventional smear, cell block, and combination of FNAC with cell block were compared with histopathological findings regarding diagnostic sensitivity, specificity, and accuracy of diagnosis.Results: Cell block was more specific to diagnose these lesions than FNAC (95.49% versus 90.09%). Combined application of cell block with FNAC was more specific (96.39%) than cell block alone with 100% diagnostic accuracy.Conclusion: Application of a combination of cell block with FNAC was more useful to diagnose intra-abdominal mass lesions.

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Histopathology Versus Cytopathology

Ussene

2020

Surgical Pathology

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Role of Cell Block in Diagnostics-A New Paradigm in Cancer Diagnosis

Cited by 7 publications

References 10 publications

The diagnostic utility of cell block as an adjunct to routine cytology

The diagnostic utility of cell block as an adjunct to routine cytology

Comparative Evaluation of Cell Block Method and Smear Cytology in Fine Needle Aspiration Cytology of Intra-abdominal Mass Lesions

Histopathology Versus Cytopathology

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