Role of central endothelin-1 in hyperalgesia, anhedonia, and hypolocomotion induced by endotoxin in male rats

Lomba, Luís Alexandre; Cruz, Juliana Varella; Coelho, Leticia; Leite-Avalca, M. C. G.; Correia, Diego; Zampronio, Aleksander Roberto

doi:10.1007/s00221-020-05929-1

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…The mechanical threshold was measured using an electronic von Frey anesthesiometer (Bonther, Ribeirão Preto, SP, Brazil) as described previously (Lomba et al, 2021;Soares et al, 2017). The mice were rst acclimated for 1 h in individual clear Plexiglas boxes (9 × 7 × 11 cm) on an elevated wire mesh platform to allow access to the plantar surface of the hindpaws.…”

Section: Mechanical Hyperalgesiamentioning

confidence: 99%

Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta

Barbosa,

Ehrenfried,

Radulski

et al. 2024

Inflammopharmacol

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The present study aimed to evaluate the composition of the crude extracts obtained from the leaves of Cantinoa stricta (Lamiaceae) and explore the antinociceptive and anti-in ammatory activity of these extracts and two isolated compounds: anamarine (ANA) and 10-epi-olguine (eOL). Different extracts were obtained from the leaves of C. stricta and compared by NMR data. Crude ethanolic extract (EEt) and dichloromethane extract (DCM) were selected for the pharmacological tests in mice. The oral administration of EEt and DCM in male Swiss mice signi cantly reduced the second phase of formalininduced nociception, lipopolysaccharide (LPS)-induced mechanical hyperalgesia, and carrageenan (Cg)induced edema. ANA and eOL, the major compounds in EEt and DCM extracts, administered orally or locally (in the paw), also reduced the LPS-induced mechanical hyperalgesia and the Cg-induced edema without changing the thermal acute nociception or the motor performance of the animals. These isolated compounds did not change the mechanical hyperalgesia induced by tumor necrosis factor-α, interleukin-1β, prostaglandin E2, dibutyryl cyclic AMP, or forskolin but reversed the hyperalgesia induced by dopamine, epinephrine, and phorbol 12-myristate 13-acetate. The mechanical hyperalgesia induced by epinephrine was reversed in male but not in female mice, in which this response is not dependent on protein kinase C. These results suggest that C. stricta extracts possess antinociceptive and antiin ammatory activity which is, at least partially related to the presence of ANA and eOL. Differently from the known analgesics, these substances seem to exert their action mainly interfering with the sympathetic component of pain, possibly with protein kinase C.

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Section: Mechanical Hyperalgesiamentioning

confidence: 99%

Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta

Barbosa,

Ehrenfried,

Radulski

et al. 2024

Inflammopharmacol

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show abstract

“…Mechanical hyperalgesia was assessed using an electronic Von Frey apparatus (Insight, Brazil) as described previously (Lomba et al 2021) with an adaptation for mice. First, the mice were placed in individual clear Plexiglas boxes (9.5 x 6.5 x 9.5 cm) on an elevated wire mesh platform for adaptation.…”

Section: Mechanical Hyperalgesiamentioning

confidence: 99%

Chemical Constituents and Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Salvia melissiflora Aerial Parts

Oliveira,

Barbosa,

Ehrenfried

et al. 2023

Rev. Bras. Farmacogn.

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Chromatographic fractionation of dichloromethane (EDSM) and ethanol (EESM) extracts of Salvia melissi ora Benth. aerial parts led to the identi cation of ve known compounds through analyses of NMR data (1D and 2D), and comparison with literature data: oleanolic acid (1), ursolic acid (2), ent-(5R,9R)-15,16-epoxy-10S-hydroxycerodan-3,13( 16),14-triene-17,12S;18,19-diolide (melissi orine, 3), 7-episalvianduline A (4) and rosmarinic acid (5). The anti-in ammatory and antinociceptive activity of EESM and EDSM were evaluated in mice. The oral administration of EESM reduced the second phase of formalin-induced nociception, the lipopolysaccharide (LPS)-induced hyperalgesia and the carrageenaninduced edema in mice. The oral administration of EDSM also reduced LPS-induced hyperalgesia without altering motor performance of the animals. The anti-in ammatory and anti-nociceptive effects are probably related to the presence of compounds 5 and 1, and 2, respectively. The antioxidant activity of the extracts was evaluated using the ORAC method. The EESM extract showed activity (TE relative: 2845.2 µmol TE g − 1 ), which can be attributed to the major presence, in this extract, of compound 5, which showed an antioxidant capacity comparable to that of caffeic acid.

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Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder

Matias

Radulski

Silva

et al. 2023

International Immunopharmacology

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Role of central endothelin-1 in hyperalgesia, anhedonia, and hypolocomotion induced by endotoxin in male rats

Cited by 7 publications

References 43 publications

Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta

Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta

Chemical Constituents and Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Salvia melissiflora Aerial Parts

Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder

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