Role of Central Serotonergic Systems on the Regulation of Feeding Behavior of Chicks in Two Different Strains

Sashihara, Kouichi; Bungo, Takashi; Ando, Ryuichi; Ohgushi, Atsushi; Kawakami, S.; Denbow, D. Michael; Furuse, Mitsuhiro

doi:10.1080/09712119.2002.9706353

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…In another study, it was observed that central administration of 5-HT resulted in the attenuation of feeding in meat-type chickens with free access to food. However, it had no meaningful effect on meal consumption of fooddeprived chickens (36). In this study, we demonstrated that the inhibitory effect of NMS on meal consumption was significantly attenuated via PCPA (serotonin synthesis inhibitor) (P<0.05), whereas this effect was enhanced by fluoxetine (5-HT reuptake inhibitor) pretreatment (P<0.05).…”

Section: Discussionmentioning

confidence: 71%

Central serotoninergic system mediates Neuromedin S (NMS) induced hypophagia in layer-type chicken

Najafi,

Mahdavi,

Zendehdel

et al. 2023

J Poult Sci Avian Dis

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According to previous studies, the serotonergic system plays a remarkable role in regulating meal intake, however, its role in the mediation of feeding caused by neuromodulin S (NMS) has not been investigated in birds. In the present research, 5 trials were considered in order to determine the links between these systems. In treatment 1, chickens received intracerebroventricular (ICV) infusion of NMS (0.25, 0.5, and 1 nmol). NMS (1 nmol), SB242084 (1.5 μg), a 5-HT2C receptor antagonist, and NMS + SB242084 were injected in the treatment 2. In subsequent treatments, instead of SB242084, 8-OH-DPAT (agonist of 5-HT1A receptor, 15.25 nmol), PCPA (serotonin synthesis inhibitor, 1.25 μg), and Fluoxetine (serotonin reuptake inhibitor, 10 μg) were applied. Then, total food consumption was recorded for 120 minutes. Based on observations, NMS dose-dependently attenuated meal intake (P<0.05). Hypophagia was diminished with NMS + SB242084 administration (P<0.05). ICV infusion of NMU + 8-OH-DPAT had no significant effect on the hypophagia (P≥0.05). The NMS-induced decreasing feed intake was attenuated with co-infusion of NMS+ PCPA (P< 0.05). Also, hypophagia was strengthened by NMS+ Fluoxetine co-infusion (P< 0.05). According to the results, the NMS-induced hypophagia is possibly mediated via 5-HT2c receptors in layer-type chickens.

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Section: Discussionmentioning

confidence: 71%

Central serotoninergic system mediates Neuromedin S (NMS) induced hypophagia in layer-type chicken

Najafi,

Mahdavi,

Zendehdel

et al. 2023

J Poult Sci Avian Dis

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“…This previous study further demonstrated that hypophagia induced by central tryptophan is involved in the serotonergic system. Central 5-HT has been confirmed to induce anorexia in chicks ( Denbow et al ., 1982 , 1986 ; Sashihara et al ., 2002 ). The synthesis of 5-HT depends on the availability of its precursor tryptophan in the brain ( Schaechter and Wurtman, 1990 ).…”

Section: Discussionmentioning

confidence: 99%

Central Interaction Between L-Ornithine and Neuropeptide Y in the Regulation of Feeding Behavior of Neonatal Chicks

et al. 2023

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Ornithine has been identified as a potential satiety signal in the brains of neonatal chicks. We hypothesized that brain nutrient signals such as amino acids and appetite-related neuropeptides synergistically regulate food intake. To test this hypothesis, we investigated the interaction between neuropeptide Y (NPY) and ornithine in the control of feeding behavior in chicks and the associated central and peripheral amino acid metabolic processes. Five-day-old chicks were intracerebroventricularly injected with saline, NPY (375 pmol), or NPY plus ornithine (2 or 4 μmol) at 10 μl per chick, and then subjected to ad libitum feeding conditions; food intake was monitored for 30 min after injection. Brain and plasma samples were collected after the experiment to determine free amino acid concentrations. Co-injection of NPY and ornithine significantly attenuated the orexigenic effect induced by NPY in a dose-dependent manner. Central NPY significantly decreased amino adipic acid, asparagine, γ-aminobutyric acid, leucine, phenylalanine, tyrosine, and isoleucine levels, but significantly increased lysine levels in the brain. Co-injection of NPY and ornithine significantly increased ornithine and proline levels in all examined brain regions, but decreased diencephalic tryptophan and glycine levels compared with those of the control and NPY-alone groups. Co-injection of NPY and high-dose ornithine significantly decreased methionine levels in all brain regions. Central NPY significantly suppressed the plasma concentrations of amino acids, including proline, asparagine, methionine, phenylalanine, tyrosine, leucine, isoleucine, glycine, glutamine, alanine, arginine, and valine, and this reduction was greater when NPY was co-injected with ornithine. These results suggest that brain ornithine interacts with NPY to regulate food intake in neonatal chicks. Furthermore, central NPY may induce an anabolic effect that is modified by co-injection with ornithine.

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Central regulation of feeding behavior through neuropeptides and amino acids in neonatal chicks

Tran¹,

Chowdhury

Furuse³

2019

Amino Acids

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Role of Central Serotonergic Systems on the Regulation of Feeding Behavior of Chicks in Two Different Strains

Cited by 10 publications

References 12 publications

Central serotoninergic system mediates Neuromedin S (NMS) induced hypophagia in layer-type chicken

Central serotoninergic system mediates Neuromedin S (NMS) induced hypophagia in layer-type chicken

Central Interaction Between L-Ornithine and Neuropeptide Y in the Regulation of Feeding Behavior of Neonatal Chicks

Central regulation of feeding behavior through neuropeptides and amino acids in neonatal chicks

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