Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach

Rezaeeyan, Hadi; Shirzad, Reza; McKee, Trevor D.; Saki, Najmaldin

doi:10.1111/apm.12818

Cited by 20 publications

(26 citation statements)

References 100 publications

(103 reference statements)

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“…Chemokines are critical for embryonic development and cancer metastasis . They can be secreted by many organs and bind to specific receptors on plasma membranes of target cells.…”

Section: Discussionmentioning

confidence: 99%

A Novel Tissue‐Based Liver–Kidney‐on‐a‐Chip Can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells

Tian

Pang

Qin

et al. 2019

Biotechnology Journal

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Extracellular vesicles (EVs) from cancer cells remodel distant organs to promote metastasis in vivo. A biomimetic microsystem may compensate costly and time-consuming animal models to accelerate the study of EV organotropism. A tissue-based liver-kidney-on-a-chip is developed with precision-cut tissue slices (PTSs) cultured to represent individual organs. The organotropism of breast cancer EVs is modeled using the biomimetic microsystem. A traditional animal model of EV organotropism is used to investigate the physiological similarity of the microfluidic model to animal models. It is demonstrated that breast cancer EVs show strong liver tropism rather than kidney tropism on both the microfluidic and animal models. It isfound that the metastatic inhibitor AMD3100 inhibits liver tropism effectively in both the microfluidic and animal models. Overall, the tropism of EVs to different organs is reconstituted on the microfluidic model. The liver-kidney-on-a-chip may expand the capabilities of traditional cell culture models and provide a faster alternative to animal models for EV studies.

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“…Chemokines are critical for embryonic development and cancer metastasis . They can be secreted by many organs and bind to specific receptors on plasma membranes of target cells.…”

Section: Discussionmentioning

confidence: 99%

A Novel Tissue‐Based Liver–Kidney‐on‐a‐Chip Can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells

Tian

Pang

Qin

et al. 2019

Biotechnology Journal

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“…At the new distant locations, cancer cells can exploit the chemokine system to establish immune system suppression and angiogenesis for the formation of a pre-metastatic niche, and to facilitate the proliferation of metastatic cancer cells [129]. For example, CCL2 stimulates metastatic seeding of BC cells by increasing the retention of metastasis-associated macrophages [130].…”

Section: Roles Of Chemokine System In Tumor Metastasismentioning

confidence: 99%

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

Thu

Lee

Cho

2020

Cancers

164

131

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Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid tissue development. Recent advances have indicated that chemokines and their cognate receptors play critical roles in cancer-related inflammation and cancer progression. On the basis of these findings, the chemokine system has become a new potential drug target for cancer immunotherapy. In this review, we summarize the essential roles of the complex network of chemokines and their receptors in cancer progression. Furthermore, we discuss the potential value of the chemokine system as a cancer prognostic marker. The chemokine system regulates the infiltration of immune cells into the tumor microenvironment, which induces both pro- and anti-immunity and promotes or suppresses tumor growth and proliferation, angiogenesis, and metastasis. Increasing evidence indicates the promising prognostic value of the chemokine system in cancer patients. While CCL2, CXCL10, and CX3CL1/CX3CR1 can serve as favorable or unfavorable prognostic factors depending on the cancer types, CCL14 and XCL1 possess good prognostic value. Other chemokines such as CXCL1, CXCL8, and CXCL12 are poor prognostic markers. Despite vast advances in our understanding of the complex nature of the chemokine system in tumor biology, knowledge about the multifaceted roles of the chemokine system in different types of cancers is still limited. Further studies are necessary to decipher distinct roles within the chemokine system in terms of cancer progression and to validate their potential value in cancer prognosis.

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“…As recently reviewed, the alteration of this signalling pathway may contribute to leukaemogenesis [ 31 ]. In addition to its involvement in haematopoiesis, CXCL12/CXCR4 signalling is required for stem cell migration and homing in other developmental processes, such cardiogenesis, angiogenesis and neurogenesis [ 29 ], and also for cancer cell migration and metastasis [ 32 ].…”

Section: Redox Signalling In Haematopoiesismentioning

confidence: 99%

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

Prieto-Bermejo

Romo-González

Pérez-Fernández

et al. 2018

J Exp Clin Cancer Res

104

115

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Oxidative stress is related to ageing and degenerative diseases, including cancer. However, a moderate amount of reactive oxygen species (ROS) is required for the regulation of cellular signalling and gene expression. A low level of ROS is important for maintaining quiescence and the differentiation potential of haematopoietic stem cells (HSCs), whereas the level of ROS increases during haematopoietic differentiation; thus, suggesting the importance of redox signalling in haematopoiesis. Here, we will analyse the importance of ROS for haematopoiesis and include evidence showing that cells from leukaemia patients live under oxidative stress. The potential sources of ROS will be described. Finally, the level of oxidative stress in leukaemic cells can also be harnessed for therapeutic purposes. In this regard, the reliance of front-line anti-leukaemia chemotherapeutics on increased levels of ROS for their mechanism of action, as well as the active search for novel compounds that modulate the redox state of leukaemic cells, will be analysed.

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Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach

Cited by 20 publications

References 100 publications

A Novel Tissue‐Based Liver–Kidney‐on‐a‐Chip Can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells

A Novel Tissue‐Based Liver–Kidney‐on‐a‐Chip Can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

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