Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism

Abstract

This case report illustrates the challenges in diagnosis of choriocarcinoma presenting with respiratory manifestations, and highlights the importance of early diagnosis and timely appropriate chemotherapy in management of this disease.

A rare case of a giant arterio-venous fistula (AVF) following metastatic choriocarcinoma conditioning pulmonary embolism: multimodal transcatheter embolization using a simultaneous transarterial and transvenous approach

“…It affects one in 40 000 pregnancies and one in 40 hydatidiform moles and can determine massive uterine bleeding and arterio-venous fistula (AVF), in selected cases treated with transcatheter embolization (Alturkistani et al, 2016; Wang et al, 2017). Choriocarcinoma-associated pulmonary thromboembolism represents another complication (Zhu et al, 2016) and thrombolysis a potential therapeutic option (Yang & Peng, 2017). Despite this aggressive behaviour, it has a good prognosis due to the valid response to systemic chemotherapy (Wang et al, 2017; Yang & Peng, 2017).…”

“…Choriocarcinoma-associated pulmonary thromboembolism represents another complication (Zhu et al, 2016) and thrombolysis a potential therapeutic option (Yang & Peng, 2017). Despite this aggressive behaviour, it has a good prognosis due to the valid response to systemic chemotherapy (Wang et al, 2017; Yang & Peng, 2017). This can be monitored by serum beta Human Chorionic Gonadotropin (β-HCG) measurements, secreted by the tumor.…”

Multiple embolic infarctions and intracranial hemorrhage in a patient with gestational trophoblastic disease

“…The effects of thrombolytic therapy, embolectomy, and/or anticoagulant therapy were uncertain in these cases. The literature highlights the importance of early diagnosis and timely appropriate chemotherapy in the management of this condition [10]. In our case, the patient was diagnosed with PTTM.…”

“…Although we could not perform TEE, there was no evidence of non-bacterial thrombotic endocarditis on TTE. Several cases of choriocarcinoma with pulmonary thromboembolism have been reported previously [10]. The effects of thrombolytic therapy, embolectomy, and/or anticoagulant therapy were uncertain in these cases.…”

Comparative Pharmacological Investigations of N-Hexane Fractions of Bauhinia Scandens LINN.STEMS and Senna Sophera L. Stems

“…The diagnosis of patients with cerebral epithelial duct occlusion is made possible by clotbuster drugs including proteinase, alteplase (activase), reteplase (Retavase), tenecteplase (TNKasase, Streptokinase, Urokinase, etc [2]. Most thrombolytic regimens that are currently available have some vital deficiencies including minimal fibrin specificity, significant bleeding, and the high dose needs when they are used to lyse existing blood coagulation in clinical configurations in which ischemia (critical myocardial infarction, lung embolism, ischemia, and arterial thrombotic infarction) can be suspicious [3].Choriocarcinoma medication along with chemotherapy is also managed with thrombolytic therapy [4].Cytotoxicity screening models provide valuable preliminary information for selecting plant extracts for future research with possible anti-neoplastic properties [5]. This is why scientists are looking for less injurious human cytotoxic substances.…”