Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Lee, Anne; Chan, Anthony T.C.; Li, Wenfei; Aupérin, Anne; Blanchard, Pierre; Benhamou, E; Bourhis, Jean; Carmel, Alexandra; Chakrabandhu, Somvilai; Chan, Anthony T.C.; Chen, Lei; Chen, Ming‐Yuan; Chen, Qiuyan; Chen, Yong; Chappell, Richard J.; Choi, H.C.W.; Chua, Daniel T.T.; Chua, Margaret; Fountzilas, George; Higgins, Julian P T; Hong, Ming; Hong, Ruey‐Long; Huang, Pei‐Yu; Hui, Edwin P.; Hsiao, Chin‐Fu; Kam, Michael K.M.; Koliou, G.-A.; Kwong, Dora Lai Wan; Lacas, Benjamin; Lai, Shu-Chuan; Lam, Ka On; LeBlanc, Michael; Lee, Anne W.M.; Lee, Ho Fun Victor; Li, Wen Fei; Lim, Yu Liang; B.Y., Brigette; Ma, Jun; Mai, Hai‐Qiang; Mo, Frankie; Moon, James; Ng, Wai Tong; Ngan, Roger K.C.; Ollivier, Camille; Huang, Shao Hui; Petit, Claire; Pignon, Jean‐Pierre; Poh, Sharon Shuxian; Rücker, Gerta; Sham, Jonathan S. T.; Soong, Yoke Lim; Sun, Ying; Tan, Terence; Tang, Lin‐Quan; Tung, Yuk; Wee, Joseph; Wu, Xudong; Xu, Tingting; Zhang, Li; Zhang, Yuan; Zhu, Guopei

doi:10.1016/s1470-2045(23)00163-8

Cited by 24 publications

(2 citation statements)

References 61 publications

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“…In pediatric patients with advanced NPC, the use of NCT + CCRT regimen tends to improve long-term DMFS and has acceptable toxicity ( 36 ). A recent meta-analysis showed that the addition of induction or adjuvant chemotherapy to CCRT enhances overall survival in NPC compared to chemotherapy alone ( 37 ). However, the inclusion of chemotherapy has led to an increase in acute toxicities ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Global trends in research of nasopharyngeal carcinoma: a bibliometric and visualization analysis

An,

Liu,

Lin

et al. 2024

Front. Oncol.

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ObjectiveThis study aims to assess the current research status, focus areas, and developmental trends in nasopharyngeal carcinoma (NPC) through a bibliometric analysis. MethodsArticles focusing on NPC published from 2000 to 2023 were retrieved from the Web of Science database. VOSviewer and CiteSpace were used for bibliometric and visual analysis. ResultsA total of 14516 related publications were retrieved. There has been a steady increase in the number of NPC-related publications from 2000 to 2023. China was the dominant country in this field with 8948 papers (61.64%), followed by the USA (2234, 15.39%). Sun Yat-sen University was the most influential institution, while Ma J was the most prolific author. Furthermore, Head And Neck-journal For The Sciences And Specialties Of The Head And Neck was the most prolific journal. International Journal of Radiation Oncology Biology Physics had the highest total citation counts. "Introduction chemotherapy", "Concurrent chemotherapy", "Epithelial-mesenchymal transition", "Cancer stem cells", "MicroRNAs", "LncRNA", "Exosomes", and "Biomarker" were the most common keywords. The reference "Chen YP, 2019, Lancet" had the highest citations and strong outbreak value. ConclusionThe past two decades have witnessed a significant increase in research on NPC. The optimization of treatment mode is the most widely studied aspect at present. The mechanism of occurrence and development and the most favorable diagnostic and therapeutic targets are the research hotspots in the future.

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Section: Discussionmentioning

confidence: 99%

Global trends in research of nasopharyngeal carcinoma: a bibliometric and visualization analysis

An,

Liu,

Lin

et al. 2024

Front. Oncol.

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“…For years, medical practitioners and researchers have relied upon the guidelines set forth by the National Comprehensive Cancer Network (NCCN) for direction in NPC treatment. A standard approach to the therapeutic management of advanced stages of NPC has been concurrent chemoradiotherapy (CCRT) enhanced with cisplatin [9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

TPF induction chemotherapy versus PF adjuvant chemotherapy plus concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma: a multicenter, randomized controlled phase III trial

Jin,

He,

et al. 2024

Preprint

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The efficacy and safety of TPF-induced chemotherapy(IC) combined with concurrent chemoradiotherapy(CCRT) compared to CCRT and sequential PF-adjuvant chemotherapy(AC) lack randomized controlled clinical trials for evaluation, so the comparative efficacy and safety between the two approaches remain unclear. In this phase III trial(NCT03574324), 266 patients were enrolled and randomly assigned to either the IC group or the AC group. The IC group received TPF followed by CCRT, while the AC group received CCRT followed by PF. We are reporting on the primary outcome of progression-free survival (PFS) and secondary endpoints of overall survival(OS), locoregional relapse-free survival(LRFS), distant metastasis-free survival(DMFS), and toxicity profile. The 3-year PFS was similar between the two groups, with 79% for the IC group and 74.5% for the AC group (P = 0.454) at a median follow-up of 39 months. Similar findings were observed with no significant disparities in terms of OS, LRFS, and DMFS between the two treatment cohorts. Both groups had similar compliance rates for radiotherapy and chemotherapy, but the IC group experienced fewer toxic effects during CCRT, such as swallowing and dryness (40 [30.53%] vs 56 [43.75%] patients and 58 [44.27%] vs 86 [67.19%] patients, respectively).In this randomized clinical trial, IC did not improve 3-year PFS for LA-NPC patients but it did reduce the incidence rates of swallowing and dry mouth during radiotherapy.

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Spezielle Tumorentitäten im Kopf-Hals-Bereich: Karzinome von Nasopharynx, Speicheldrüsen, Nasenhaupt/-nebenhöhlen und Schilddrüse

Zech,

Betz

2024

HNO

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Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Cited by 24 publications

References 61 publications

Global trends in research of nasopharyngeal carcinoma: a bibliometric and visualization analysis

Global trends in research of nasopharyngeal carcinoma: a bibliometric and visualization analysis

TPF induction chemotherapy versus PF adjuvant chemotherapy plus concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma: a multicenter, randomized controlled phase III trial

Spezielle Tumorentitäten im Kopf-Hals-Bereich: Karzinome von Nasopharynx, Speicheldrüsen, Nasenhaupt/-nebenhöhlen und Schilddrüse

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