Role of chemotherapy in treatment of squamous cell carcinoma of the penis

Pagliaro, Lance C.

doi:10.1016/j.currproblcancer.2015.03.008

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…Cisplatin—alone as a radiosensitizing agent or in combination with 5-fluorouracil—and 5-fluorouracil were the most frequently used drugs. The addition of a taxane or ifosfamide was not used as currently recommended [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?

Coelho¹,

Pinho²,

Moreno³

et al. 2018

BMC Urol

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BackgroundThe objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease.MethodsA retrospective study of 392 patients diagnosed with penile cancer in the three most important referral center in the state was conducted during 2004–2014.ResultsThe age-standardized incidence was 6.15 per 100,000 and the crude annual incidence was 1.18 per 100,000. More than half (61.1%) of the tumors were histological grades 2 and 3, and 66.4% of tumors were classified as at least stage T2. The average age of patients was 58.6 ± 15.7 years (range, 18 to 103 years), with 20.8% of patients ≤40 years of age at diagnosis. The vast majority underwent penectomy (93%). Only 41.8% underwent lymphadenectomy, 58 patients (14.8%) received chemotherapy, and 54 patients (13.8%) received radiotherapy. Stage 3/4 and vascular invasion were statically significant at disease-free survival analysis.ConclusionThe state of Maranhão has the highest incidence of penile cancer in Brazil and globally. Tumors are locally advanced and at the time of diagnosis, and there is a high frequency among young individuals. Patients have a low socioeconomic status, making it difficult to complete treatment and receive appropriate follow-up.

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Section: Discussionmentioning

confidence: 99%

Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?

Coelho¹,

Pinho²,

Moreno³

et al. 2018

BMC Urol

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“…The main chemotherapeutic agents used were cisplatin and 5-fluorouracil. Platinum-based triple regimens, until then considered standard, were used in isolated cases 23 , 24 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological study of penile cancer in a northeastern state - Brazil

Silva,

Ximenes,

Santos

et al. 2023

Rev. Col. Bras. Cir.

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Objective: to trace the clinical and epidemiological profile of penile cancer in Rio Grande do Norte/Brazil and relate them to data published in the literature. Methods: a cross-sectional study was conducted with 94 patients diagnosed with penile cancer in 2011-2018, treated at the Liga Norte Riograndense Contra o Cancer. Results: all patients were diagnosed with squamous cell carcinoma, mainly aged over 50 years, from the states interior, brown, illiterate, or with incomplete primary education. At diagnosis, 68% of patients were classified as having tumors =T2, and 30% had lymph node involvement. Distant metastases were detected in 2.1% of patients at diagnosis. Most patients received the diagnosis in the initial phase of the disease, but 20.2% were diagnosed in stage IV. Partial penectomy was the most performed surgery, and 10% of patients relapsed, mainly in the lymph nodes (87.5%). The mean follow-up of the patients was 18 months, with an estimated overall survival at five years of 59.1%. However, 25% of patients were followed up for up to 3 months, losing follow-up. Conclusion: the State of Rio Grande do Norte has a high incidence of penile cancer with a high frequency of locally advanced tumors at diagnosis and in younger patients younger than 50. Furthermore, socioeconomic factors interfere with early diagnosis and hinder access to specialized services.

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“…Chemotherapy is used as preoperative and postoperative adjuvant therapy with a low clinical response rate of 30%, ranging from 20 to 70% [14]. DDP is widely used in cancer chemotherapy and is the most commonly used chemotherapy agent in advanced PeSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Most of patients with pTis, pTaG1-2, or pT1G1 disease do not benefit from radical inguinal lymph node dissection (ILND) and may suffer complications [3]. Adjuvant chemotherapy is required for advanced metastatic disease, but first line cisplatin (DDP)-based chemotherapy achieved response rates of only 30 to 35% and short overall survival [14]. Diagnostic and therapeutic advances for PeCa associated LNM have not been achieved.…”

Section: Introductionmentioning

confidence: 99%

Establishment and characterization of a penile cancer cell line, penl1, with a deleterious TP53 mutation as a paradigm of HPV-negative penile carcinogenesis

Chen

Yao²,

Li³

et al. 2016

Oncotarget

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PurposeTo establish penile cancer (PeCa) cell lines for the study of molecular mechanisms of carcinogenesis and testing therapeutic reagents.Materials and MethodsWe successfully established two PeCa cell lines from fresh tumor tissues from 21 cases. One cell line named Penl1 was isolated from a lymph node metastasis (LNM) of penile squamous cell carcinoma (PeSCC), usual type and comprehensively characterized here. Our in-depth characterization analysis of the Penl1 cell line included morphology, tumorigenicity, genetic characteristics, protein expression, biology, and chemosensitivity. Penl1 was authenticated by single tandem repeat (STR) DNA typing.ResultsComparative histomorphology, genetic characteristics, and protein expression patterns revealed essential similarities between the cell line and its corresponding LNM. In-depth characterization analysis of Penl1 cell line revealed tumorigenicity in immunodeficient mice, negative human papilloma virus (HPV) and mycoplasma infection, TP53 mutations and sensitivity to cisplatin and epirubicin. STR DNA typing did not match any cell lines within three international cell banks. The limitation of this study is that one patient cannot represent the complete heterogeneity of PeCa, especially primary tumor.ConclusionsWe established and characterized an HPV-negative and moderately differentiated PeCa cell model with a TP53 missense mutation from a PeSCC, usual type patient. A preliminarily study of carcinogenesis and chemosensitivity suggests that this cell model carries a tumor suppressor gene mutation and is sensitive to chemotherapy drugs.

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Role of chemotherapy in treatment of squamous cell carcinoma of the penis

Cited by 6 publications

References 32 publications

Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?

Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?

Epidemiological study of penile cancer in a northeastern state - Brazil

Establishment and characterization of a penile cancer cell line, penl1, with a deleterious TP53 mutation as a paradigm of HPV-negative penile carcinogenesis

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