Role of Chlamydia trachomatis intraocular infection in the development of proliferative vitreoretinopathy (experimental study)

Boiko, Ernest V.; Pozniak, A L; Суетов, А. А.; Maltsev, Dmitrii S.; Nuralova, Irina V.

doi:10.17116/oftalma2015131150-56

Cited by 2 publications

(1 citation statement)

References 15 publications

(13 reference statements)

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“…The KEGG pathways showed that infection and Phosphoinositide 3-kinase (PI3K)-Akt signaling pathway come out in front in RD tissues with PVR. Cytomegalovirus, chlamydia trachomatis, and human immunodeficiency virus have been confirmed in many RD cases [24][25][26][27]. These are in conformance with our analysis and remind us of necessary etiological detection for tissues in vitreous cavity and possible targeted treatment.…”

Section: Clinical Researchsupporting

confidence: 89%

Construction for Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Human Retinal Detachment (RD) with Proliferative Vitreoretinopathy (PVR)

Yao

Zhang

2020

Med Sci Monit

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The aim of this study was to analyze the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network in human retinal tissues following detachment with proliferative vitreoretinopathy (PVR). Material/Methods:Expression data of 19 human detached retinas with PVR and 19 normal retinas from postmortem donors were downloaded from Gene Expression Omnibust (GEO) database (GSE28133). The R package "limma" was utilized to discriminate the dysregulated lncRNA and mRNA profiles. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of differentially expressed mRNAs were performed using R packages "Clusterprofiler." The ceRNA network of dysregulated genes was constructed by using mircode, miRDB, miRTarBase and TargetScan databases, and was visualized by Cytoscape v3.6.1. Results:A total of 23 lncRNAs and 994 mRNAs were identified significantly expressed between the human detached retinas with PVR and the normal retina tissues, with thresholds of |log 2 FoldChange| >1.0 and adjusted P-value <0.05. The constructed ceRNA network (lncRNA-miRNA-mRNA regulatory axis) included 9 PVR-specific lncRNAs, as well as 27 miRNAs and 73 mRNAs. Conclusions:We demonstrated the differential lncRNA expression profile and constructed a lncRNA-associated ceRNA network in human detached retinas with PVR. This may ferret out an unknown ceRNA regulatory network in human retinal detachment with PVR.

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Section: Clinical Researchsupporting

confidence: 89%

Construction for Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Human Retinal Detachment (RD) with Proliferative Vitreoretinopathy (PVR)

Yao

Zhang

2020

Med Sci Monit

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Хламидиозы Животных И Человека

Fedorova¹,

Ляпина²,

Хижнякова³

et al. 2019

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В книге обобщаются современные достижения в области биологии хламидий, способных вызывать острые и хронические хламидийные инфекции животных и человека. Кратко изложена история исследований хламидиоза, рассматриваются молекулярная биология возбудителей, клинические формы заболевания, лабораторная диагностика, иммунология и профилактика. Для вирусологов, микробиологов, иммунологов и практикующих врачей.

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Role of Chlamydia trachomatis intraocular infection in the development of proliferative vitreoretinopathy (experimental study)

Cited by 2 publications

References 15 publications

Construction for Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Human Retinal Detachment (RD) with Proliferative Vitreoretinopathy (PVR)

Construction for Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Human Retinal Detachment (RD) with Proliferative Vitreoretinopathy (PVR)

Хламидиозы Животных И Человека

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