Role of Cholecystokinin, Gastrin and Gastrin-Releasing Peptide in the Regulation of Pancreatic Secretion in Cats

Konturek, Stanisław J.; Bilski, Jan; Hladij, Mariusz; Krzyzek, Eugeniusz; Cai, Renzhi

doi:10.1159/000200708

Cited by 9 publications

(1 citation statement)

References 21 publications

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“…This proposal was made because Bn- related peptides and/or activation of BnRs has been shown to play an important role in various inflammatory processes. Evidence supports a role for Bn related peptides and their receptors in a wide spectrum of inflammatory processes including gastritis [263,264,266,288], uveitis [260,264,266], arthritis [98,100,10,251,252,264,266], small intestinal or colonic inflammation [5,12,104,264,266], experimental sepsis [52,61,264,266,267], acute lung inflammation and injury [59,65,264,266,266,341] and gastrointestinal inflammation [10,151,264,266]. These studies suggest BnRs plays different roles in these processes because in some inflammatory processes Bn/GRP is protective and ameliorates the damage from various noxious agents in the stomach, small intestine and in the colon [5,9,12,104,264,266,284], whereas in other inflammatory conditions of the colon or lung, either Bn/GRP stimulate the inflammation or Bn/GRP antagonists ameliorate the inflammation [59,62,65,260,264,266,341,382].…”

Section: Bnr Function In Disease and A Therapeutic Target (Table 3)mentioning

confidence: 99%

Insights into bombesin receptors and ligands: Highlighting recent advances

et al. 2015

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This following article is written for Prof. Abba Kastin’s Festschrift, to add to the tribute to his important role in the advancement of the role of peptides in physiological, as well as pathophysiological processes. There have been many advances during the 35 years of his prominent role in the Peptide field, not only as editor of the journal Peptides, but also as a scientific investigator and editor of two volumes of the Handbook of Biological Active Peptides [146,147]. Similar to the advances with many different peptides, during this 35 year period, there have been much progress made in the understanding of the pharmacology, cell biology and the role of (Bombesin) Bn receptors and their ligands in various disease states, since the original isolation of bombesin from skin of the European frog Bombina bombina in 1970 [76]. This paper will briefly review some of these advances over the time period of Prof Kastin 35 years in the peptide field concentrating on the advances since 2007 when many of the results from earlier studies were summarized [128,129]. It is appropriate to do this because there have been 280 articles published in Peptides during this time on Bombesin-related peptides and it accounts for almost 5% of all publications. Furthermore, 22 Bn publications we have been involved in have been published in either Peptides [14,39,55,58,81,92,93,119,152,216,225,226,231,280,302,309,355,361,362] or in the Prof Kastin’s Handbook of Biological Active Peptides [137,138,331].

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