Role of Circadian Rhythm and Impact of Circadian Rhythm Disturbance on the Metabolism and Disease

Han, Hui; Dou, Jinming; Hou, Qingqing; Wang, Huanjun

doi:10.1097/fjc.0000000000001178

Cited by 16 publications

(8 citation statements)

References 130 publications

(206 reference statements)

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“…For instance, circadian misalignment and disruptions in circadian rhythms have been associated with an increased risk of various diseases, including cancer (20)(21)(22)(23). The maintenance of normal levels of PER1 and BMAL1 is crucial for proper functioning of the circadian rhythm, and disruptions in their expression can have significant implications for human health (24). Mrtadichol@100 ng was used to maintain normal levels.functioning of the circadian rhythm, and disruptions in their expression can have significant implications for human health ().…”

Section: Interactionsmentioning

confidence: 99%

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Metadichol® induced expression of circadian clock transcription factors in human fibroblasts

Raghavan

2024

Preprint

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The circadian clock genes play a significant role in various aspects of health and disease, including sleep, metabolism, inflammation, and cancer. CRY1, BMAL1, PER1, PPARGC1A, and CLOCK are key circadian clock genes that govern the daily rhythms of diverse physiological processes in mammals. These genes create a feedback loop called a transcriptional-translational feedback loop (TTFL). In this loop, the heterodimer of CLOCK and BMAL1 stimulates the production of CRY1, PER1, and other clock genes. Moreover, the CRY1 and PER1 proteins suppressed the activity of CLOCK-BMAL1. PPARGC1A is a transcription factor that regulates the expression of clock genes and metabolic genes. Only a limited number of agonists are currently known to activate these genes. In this study, we showed that treatment with metadichol, a nanoemulsion of long-chain alcohols, significantly increased the expression of the CRY1, CLOCK, and PPARGC1A genes by 4-5-fold in human fibroblasts. Additionally, 100 ng of metadichol maintained the expression of the PER1 and BMAL1 genes, as confirmed by quantitative real-time polymerase chain reaction (Q-rt-PCR) data. The lack of significant changes in PER1 and BMAL1 expression suggested that metadichol does not directly affect these genes. However, since these genes are part of the core circadian clock machinery, their normal functioning is crucial for maintaining the circadian rhythm.

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Section: Interactionsmentioning

confidence: 99%

“…Circadian rhythms are intrinsic 24-hour cycles that are fundamental to physiological and behavioral processes in almost all organisms, including humans. These rhythms are driven by a biological clock, a complex orchestration of genes and proteins that regulate the timing of various bodily functions (1,2).…”

Section: Introduction;mentioning

confidence: 99%

Metadichol® induced expression of circadian clock transcription factors in human fibroblasts

Raghavan

2024

Preprint

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“…Overexpression of clock components can also prevent the generation of deleterious vascular phenotypes (Qin and Deng, 2015). Circadian rhythms also regulate metabolism and digestion primarily via through this feedback loop (Zhong et al, 2018;Segers and Depoortere, 2021), which controls and drives metabolism, mainly including neurotransmitters, hormones, amino acids, and lipids (Han et al, 2022). Meanwhile, the circadian rhythm and metabolism interact with each other to maintain normal physiological activities (Reinke and Asher, 2019;Takahashi, 2019;Sinturel et al, 2020).…”

Section: B C a Figurementioning

confidence: 99%

Application of transcriptome analysis to investigate the effects of long-term low temperature stress on liver function in the tiger puffer (Takifugu rubripes)

et al. 2022

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The tiger puffer (Takifugu rubripes) is an important economic fish species in northern China. However, it is a warm-temperature species, and low winter temperatures can result in high mortality in aquaculture. Understanding the mechanisms of cold resistance in tiger puffers will thus provide critical information to help cope with winter cold. In this study, we performed transcriptome analysis of livers from puffer fish kept at different temperatures (18°C, 13°C, and 8°C) to identify the key pathways and genes involved in the response to low-temperature stress. We also detected serum levels of proteases, arginine, and proline to obtain further information on the response to cold adaption. Totals of 51, 942, and 195 differentially expressed genes were identified in the 18°C vs 13°C, 18°C vs 8°C, and 13°C vs 8°C groups, respectively. Pathway analysis showed that significantly enriched pathways were mainly related to digestion, metabolism, and environmental adaptation. Most genes in the pathways related to digestion and metabolism were down-regulated, while most genes in the pathways related to environmental adaptation were up-regulated. Serum levels of proteases were significantly lower in the low-temperature groups (13°C and 8°C) compared with the control group (18°C), while arginine and proline levels were significantly higher in the 8°C group compared with the other two groups. These results suggest that low temperature caused digestive and metabolic disorders, as well as adaptive changes to low temperature in tiger puffers. On this premise, we found that some up-regulated genes in the pancreatic secretion pathway, arginine and proline metabolism pathway, and circadian rhythm pathway played important roles in the survival, growth, and development of tiger puffers under low-temperature stress. The accumulation of arginine and proline can maintain metabolism and circulation and resist cold stress. The circadian rhythm is closely related to digestion and metabolism, which is an adaptive change and plays a positive role in the resistance to low temperature. The results of this study provide new insights and a theoretical basis for the study of cold tolerance in tiger puffers.

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“…Recent study reported that circadian rhythms is a controllable therapeutic strategy that can improve obesity [8,9]. The circadian rhythms are governed by in the suprachiasmatic nucleus, which is in the hypothalamus of the brain [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Exercise Sequence and Circadian Rhythms on Molecular Mechanisms of Muscle Hypertrophy and Mitochondrial Biogenesis in Obese Rat

Cho,

Lee,

Seo

2023

Exerc Sci

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PURPOSE: This study aimed to investigate whether endurance and resistance training sequences and circadian rhythms affect muscle hypertrophy and mitochondrial biogenesis-related molecules in obese rats.METHODS: Rats were randomly divided into five groups: the obesity control group (OCG), aerobic-resistance exercise in the morning group (ARMG), resistance-aerobic exercise in the morning group (RAMG), aerobic resistance exercise in the evening group (AREG), and resistance-aerobic exercise in the evening group (RAEG). The exercise groups performed endurance and resistance exercises for 8 weeks according to their circadian rhythms and exercise sequences.RESULTS: We evaluated specific muscle hypertrophy and mitochondrial biogenesis markers in the flexor pollicis longus and soleus muscles using western blot and immunofluorescence techniques. The body weight was significantly decreased in the ARMG, RAMG, AREG, RAEG compared to the OCG after intervention. The soleus muscle fiber cross-sectional area and muscle hypertrophy markers p-Akt and p-mTOR were significantly increased in the AREG group compared with those in the OCG, ARMG, RAMG, and RAEG groups after exercise intervention. Most mitochondrial biogenesis-related markers were significantly increased in the RAMG group than in the other groups after exercise intervention.CONCLUSION: Our findings provide new evidence that muscle hypertrophy might be upregulated by resistance exercise after evening endurance exercise. In addition, morning resistance exercise followed by aerobic exercise, might promote mitochondrial biogenesis.

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Role of Circadian Rhythm and Impact of Circadian Rhythm Disturbance on the Metabolism and Disease

Cited by 16 publications

References 130 publications

Metadichol® induced expression of circadian clock transcription factors in human fibroblasts

Metadichol® induced expression of circadian clock transcription factors in human fibroblasts

Application of transcriptome analysis to investigate the effects of long-term low temperature stress on liver function in the tiger puffer (Takifugu rubripes)

Effects of Exercise Sequence and Circadian Rhythms on Molecular Mechanisms of Muscle Hypertrophy and Mitochondrial Biogenesis in Obese Rat

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