Role of circular RNAs and gut microbiome in gastrointestinal cancers and therapeutic targets

Abdullah, Sara Tharwat; Abdullah, Snur Rasool; Hussen, Bashdar Mahmud; Younis, Yousif Mohammed; Rasul, Mohammed Fatih; Taheri, Mohammad

doi:10.1016/j.ncrna.2023.12.002

Cited by 8 publications

(3 citation statements)

References 193 publications

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“… 9 Due to this unique feature, they exhibit enhanced stability and prolonged lifespan within cells as they can withstand degradation caused by exonucleases. 51 Yu et al. demonstrated the upregulation of circFMN2 in both serum and exosomes from CRC patients, as well as CRC cells.…”

Section: Colorectal Cancer-derived Exosomesmentioning

confidence: 99%

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

Yimin E,

Lu,

Zhu

et al. 2024

iScience

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Section: Colorectal Cancer-derived Exosomesmentioning

confidence: 99%

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

Yimin E,

Lu,

Zhu

et al. 2024

iScience

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“…In addition, there were close intricate interactions between gut microbiota, inflammation, and differential miR-NAs, suggesting that ncRNAs may possess a potential role in the protection of the host against life-related diseases such as atherosclerosis [58]. Interestingly, it has been shown that circRNAs and the gut microbiome can interact to influence the growth of cancer cells [59]. Similarly, the expression of lncRNAs could be repressed by gut microbiota [60].…”

Section: Connection Between Gut Microbiota and Alcohol Dependencymentioning

confidence: 99%

Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application

Nakashima,

Suga,

Yoshikawa

et al. 2024

Genes

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Many investigations have evaluated the expression of noncoding RNAs (ncRNAs) as well as their related molecular functions and biological machineries in individuals with alcohol dependence. Alcohol dependence may be one of the most prevailing psychological disorders globally, and its pathogenesis is intricate and inadequately comprehended. There is substantial evidence indicating significant links between multiple genetic factors and the development of alcohol dependence. In particular, the critical roles of ncRNAs have been emphasized in the pathology of mental illnesses, probably including alcohol dependence. In the comprehension of the action of ncRNAs and their machineries of modification, furthermore, they have emerged as therapeutic targets for a variety of psychiatric illnesses, including alcohol dependence. It is worth mentioning that the dysregulated expression of ncRNAs has been regularly detected in individuals with alcohol dependence. An in-depth knowledge of the roles of ncRNAs and m6A modification may be valuable for the development of a novel treatment against alcohol dependence. In general, a more profound understanding of the practical roles of ncRNAs might make important contributions to the precise diagnosis and/or actual management of alcohol dependence. Here, in this review, we mostly focused on up-to-date knowledge regarding alterations and/or modifications in the expression of ncRNAs in individuals with alcohol dependence. Then, we present prospects for future research and therapeutic applications with a novel concept of the engram system.

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“…With the rapid breakthroughs in RNA sequencing technologies and bioinformatics, the true abundance of circRNAs was discovered. In 2012, an unexpectedly high frequency of human genes was reported to express “scrambled exons” resulting in circular RNA isoforms [ [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] ].…”

Section: Interplay Between Jak/stat Signaling and Circular Rnasmentioning

confidence: 99%

Interplay between JAK/STAT pathway and non-coding RNAs in different cancers

Farooqi,

Shepetov,

Rakhmetova

et al. 2024

Non-coding RNA Research

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Role of circular RNAs and gut microbiome in gastrointestinal cancers and therapeutic targets

Cited by 8 publications

References 193 publications

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application

Interplay between JAK/STAT pathway and non-coding RNAs in different cancers

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