Role of class I HLA (G, E, and C) expression in early reproductive  losses

Bakleicheva, Bakleicheva M.O.; Bespalova, Bespalova O.N.; Ivashchenko, Ivashchenko T.E.; Reproductology, Saint Petersburg

doi:10.18565/aig.2020.2.30-36

Cited by 5 publications

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“…In recent years, relevant studies have shown that HLA class Ib play an important role in maternal-fetal immune tolerance ( 9 ). In order to prevent the fetus from being attacked by the maternal immune system, extravillous trophoblasts (EVTs) express HLA class Ib molecules such as HLA-E, HLA-F and HLA-G to change the function of DICs and regulate its subtypes ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

et al. 2022

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The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.

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Section: Introductionmentioning

confidence: 99%

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

et al. 2022

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Early pregnancy loss: the influence of endogenous risk factors

Shramko,

Matoshin,

Renge

et al. 2024

Rus. Bull. Obstet.-Gynecol.

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Biological profile of the follicular fluid. A pilot study

Bespalova

Shengelia

Zagaynova

et al. 2023

Journal of obstetrics and women's diseases

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BACKGROUND: One of the most important research areas in the field of reproductive medicine is the search for biochemical and immunological parameters of oocyte quality and predicting the effectiveness of assisted reproductive technology protocols. AIM: The aim of this study was to evaluate the expression of follicular fluid soluble human leukocyte antigen-G, human leukocyte antigen-E, human leukocyte antigen-C, progesterone-inducing blocking factor, and relaxin levels in women with reproductive disorders. MATERIALS AND METHODS: This prospective cohort study included 22 patients undergoing infertility treatment in a superovulation stimulation protocol using gonadotropin-releasing hormone antagonists. The inclusion criteria were age from 25 to 39 years, tubal-peritoneal factor infertility, and voluntary participation informed consent. The levels of soluble human leukocyte antigen-G, human leukocyte antigen-E, human leukocyte antigen-C, progesterone-inducing blocking factor, and relaxin in follicular fluid samples were determined on the day of transvaginal follicle puncture by enzyme immunoassay. RESULTS: We established an inverse correlation between the expression levels of progesterone-inducing blocking factor and relaxin (r = 0.450) in the follicular fluid, antibodies to thyroperoxidase (r = 0.649), and thyroid-stimulating hormone (r = 0.519). We also found a direct correlation between human leukocyte antigen-E parameters in the follicular fluid, age (r = 0.813) and Body Mass Index (r = 0.866), as well as between human leukocyte antigen-C expression levels and total testosterone (r = 0.960). No data were obtained on any significant correlations between the studied biomarkers and the number of received oocytes. CONCLUSIONS: In this comprehensive study, we were the first who found the expression levels of five different follicular fluid components, namely, soluble human leukocyte antigen-G, human leukocyte antigen-E, human leukocyte antigen-C, progesterone-inducing blocking factor, and relaxin. Such a complex assessment of the follicular fluid can allow for establishing the quality of the oocyte to predict the onset of pregnancy in an in vitro fertilization protocol.

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Role of class I HLA (G, E, and C) expression in early reproductive losses

Cited by 5 publications

References 0 publications

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Early pregnancy loss: the influence of endogenous risk factors

Biological profile of the follicular fluid. A pilot study

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