Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping

Honvo, Germain; Lengelé, Laetitia; Charles, Alexia; Reginster, Jean‐Yves; Bruyère, Olivier

doi:10.1007/s40744-020-00240-5

Cited by 36 publications

(38 citation statements)

References 92 publications

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“…Multiple collagen factors were also detected in the ECM-receptor interaction pathway in Figure 5 . Collagen is a vital component of cartilage composition and plays a crucial role in protecting cartilage tissues [ 58 – 60 ]. This finding suggested that the ECM-receptor interaction signaling pathway may also play a critical role in the mechanism underlying circRNA-regulated OA ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Role of circRNAs in Osteoarthritis

Zou

2021

BioMed Research International

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Objective. Provide a reference to elucidate the mechanism of circRNAs regulating osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa-circ) and osteoarthritis in the recent 5 years have been reviewed and the differential expression and regulatory effect of circRNAs in OA deduced. Based on these conclusions and Protein-Protein Interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the acquired circRNAs, the potential functions and interactions of circRNAs in OA and the involved signaling pathways are discussed. Results. A total of 33 studies meeting the inclusion criteria were included in this study, and 27 circRNAs were upregulated and 8 circRNAs were downregulated in OA. A total of 31 circRNAs were finally included in the PPI, GO, and KEGG analyses. From PPI, 12 map nodes and 7 map edges were interrelated. VWF had the biggest node and edge size. From GO, VWF showed a majority of the functions. From KEGG, circRNAs are enriched in PI3K/AKT, human papillomavirus infection (HPI), and focal adhesion (FA) pathways, and VWF was involved in major pathways. Conclusion. We found that most articles about circRNAs regulating OA in the recent 5 years focused on the mechanism, especially the absorption effect of circ-miRNA as sponges in the recent 2 years, while most of the articles about their functions addressed ECM and PI3K, AKT, and mTOR signaling pathways. Future studies might focus on the functions of circRNAs, and circRNA VWF, with preferable functions, interactions, and involvement, can be used as a biological indicator to detect OA in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Studies on the Role of circRNAs in Osteoarthritis

Zou

2021

BioMed Research International

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“…Osteoartritis je najčešća bolest zglobova i jedno od glavnih javno-zdravstvenih pitanja tekućeg veka [22]. Zbog rastućeg očekivanog trajanja života, posebno u razvijenim zemljama, njegova globalna prevalenca se brzo povećava, što ga čini bolešću povezanim sa izuzetno visokim ekonomskim opterećenjem [22,23].…”

Section: Savremena Razmatranjaunclassified

“…Osteoarthritis is the most frequent joint disease and one of the main public health issues of the century [22]. Due to increased life expectancy, especially in developed countries, its global prevalence is rapidly rising, making it a disease linked to a very high economic burden [22,23].…”

Section: Naša Tačka Gledištamentioning

confidence: 99%

Osteoarthritis, osteoarthrosis and osteoarthropathy: What is the difference?

Jeremić¹,

Gluscevic²,

Rajković³

et al. 2021

Srpski medicinski časopis Lekarske komore

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Osteoarthritis, osteoarthrosis, and osteoarthropathy are diseases that doctors encounter daily in their practice. The use of all three terms is customary, often without a clear justification as to why a particular term is used for a particular case. In the past several decades, doctors mainly differentiated among these diseases based on clinical presentation and radiography. In the past several years, however, significant progress has been made in the field of biochemical, immunological, and cytohistological research, which has provided explanations for the pathogenesis of these conditions, enabled defining differences amongst them and facilitated the use of appropriate terms for each one of these diseases. The term arthritis (osteoarthritis) should be used exclusively for primarily inflammatory joint diseases-rheumatoid arthritis, juvenile arthritis, reactive arthritis (Reiter's syndrome). If the etiology is infectious, this must also be emphasized-septic (purulent) arthritis, tuberculous arthritis. Arthrosis (osteoarthrosis) relates to changes in the joints occurring due to pathological processes within the joint itself, but which, in their basis, are not inflammatory. Arthropathy is a term for joint disease stemming from another diseased organ or system of organs.

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“…Oral collagen supplementation was found to lead to significant improvements in patients with moderate knee OA after short daily treatments with oral HA preparations, compared to placebo-treated controls (Guadagna et al, 2018). Current clinical data on oral HA products for the treatment of mild to moderate knee OA are promising, and cumulative findings appeared to support a more favourable role than not for collagen supplements in efforts to safely reduce mild to moderate OA pain of the hand, hip or knee and to improve physical function at short term (Aghamohammadi et al, 2020;Honvo et al, 2020;Liu et al, 2018;Marks, 2020), although the quality of evidence is very low (Liu et al, 2018).…”

Section: Intra-articular Hyaluronic Acid Injections and Oral Collagen Supplementationmentioning

confidence: 99%

Intra-articular hyaluronic acid injections and oral collagen supplementation for knee OA: A case report of an elite female soccer player

Tarantino¹,

Sirico²,

Corrado³

et al. 2021

Journal of Human Sport and Exercise - 2021 - Winter Conferences of Sports Science

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Soccer players are susceptible to repeated trauma that could lead to a precocious development of knee osteoarthritis (OA). Intra-articular hyaluronic acid (IA-HA) injections have been proposed as a valid treatment for knee OA. Objectives: To describe the effects of IA-HA injections and oral collagen supplementation in a female soccer goalkeeper playing in Italian Women's Serie A with secondary OA in her knee. Design: Case report. Setting: The athlete underwent three IA-HA injections (1 per week for 3 weeks in a row) together with oral collagen supplementation for one month. Treatment outcomes were evaluated using five scoring scales. Results: One week after the first IA-HA injection all the scores improved. One week after the second injection, compared with the first week, two scores improved, two remained the same, and one worsened. One week after the third injection, compared with the second week, all the scores worsened. At one month, compared with the third week, one score remained the same and all the others worsened. From baseline to one month, three scores improved, one remained the same, and one worsened. Conclusions: In our study, IA-HA injections and oral collagen supplementation showed short-term effects on pain and functional impairment for knee OA.

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Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping

Cited by 36 publications

References 92 publications

Studies on the Role of circRNAs in Osteoarthritis

Studies on the Role of circRNAs in Osteoarthritis

Osteoarthritis, osteoarthrosis and osteoarthropathy: What is the difference?

Intra-articular hyaluronic acid injections and oral collagen supplementation for knee OA: A case report of an elite female soccer player

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