Role of color and power doppler imaging in differentiating between malignant and benign solid breast masses

Lee, Sheen Woo; Choi, Hye Young; Baek, Seung Yon; Lim, Soo Mee

doi:10.1002/jcu.10100

Cited by 84 publications

(82 citation statements)

References 17 publications

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“…Thus, while the malignancy pick-up rate improved with the use of PDUS, sensitivity and NPV were reduced, resulting in an increased biopsy rate; this is similar to the results of a study conducted by Tozaki and Fukuma. (21) Studies conducted by Gokalp et al, (13) Kwak et al (14) and Lee et al (20) on the role of PDUS in predicting malignancy yielded results that were similar to those of the present study. However, we obtained a higher diagnostic accuracy of PPV and specificity for the combined B-mode greyscale US and PDUS method as compared to Kwak et al (14) The diagnostic accuracy achieved based on vessel penetration alone was relatively similar to that reported by Gokalp et al (13) One of the limitations of the present study is the possibility of bias and interobserver variability during the B-mode greyscale US and PDUS image acquisition, since it was performed in the same sitting by the two radiologists.…”

Section: A 7bsupporting

confidence: 89%

“…(17) Since PDUS measures the amplitude of blood flow, it is angle-independent and avoids aliasing artefacts. (18,19) Although PDUS has shown great potential in predicting malignancy, (16,19,20) its use is limited by the lack of standard interpretation guidelines. Hence, we aimed to assess whether the vascular pattern of lesions can be used to predict malignancy and whether the vascular pattern of a lesion correlates with its BI-RADS category.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy

Ibrahim¹,

Rahmat²,

Fadzli³

et al. 2016

smedj

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METHODSGreyscale ultrasonography (US) and PDUS were prospectively performed on 91 women in Malaysia with histopathologically proven breast lesions. The diagnostic accuracy of greyscale US, PDUS, and both greyscale US and PDUS was calculated and compared. RESULTSThe 91 women had 102 breast lesions (55 benign, 47 malignant). Of the 47 malignant lesions, 36 demonstrated intratumoural penetrating vessels. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of greyscale US findings in diagnosing malignancy were 100.0%, 71.4%, 74.1% and 100.0%, respectively. The presence of calcification in the breast lesion and the margin, shape and posterior acoustic features of the lesion were significant parameters in predicting malignancy (p < 0.01). The sensitivity, specificity, PPV and NPV of the presence of intratumoural penetrating vessels in predicting malignancy were 76.5%, 80.0%, 76.5% and 80.0%, respectively. When both greyscale US and PDUS were used, there was a significant correlation in predicting malignancy (p < 0.05). The specificity and PPV values of the combined greyscale US and PDUS method (89.0% and 85.7%, respectively) were higher than those of greyscale US or PDUS alone.CONCLUSION Flow patterns revealed by PDUS can be useful for differentiating benign and malignant breast lesions.The visualisation of penetrating vessels in solid breast lesions can be used to complement greyscale US findings in predicting malignancy.

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Section: A 7bsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy

Ibrahim¹,

Rahmat²,

Fadzli³

et al. 2016

smedj

View full text Add to dashboard Cite

show abstract

“…Currently, ultrasonography (US) and mammography are the most frequently used non-invasive methods for detecting breast cancer [1][2][3], while Doppler techniques may be used in parallel to provide additional information [4,5] and obtain better diagnostic accuracy [6,7]. Complementary to these methods, elastography adds supplementary information regarding differences in elasticity and stiffness between different tissues [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

et al. 2016

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Aims: To assess the quality of real time elastography as a differential diagnosis tool for breast nodules and to compare it with standard ultrasonography. Material and methods: In this prospective study we enrolled 174 patients in which 174 dominant breast nodules were considered for the final diagnosis. The results of ultrasonography and real time elastography, both qualitative and quantitative, were compared with pathology findings from the biopsy specimens. Results: Pathology examinations determined 102 nodules were benign and 72 malignant. Qualitative elastography had a better diagnostic performance (82.4% sensitivity and 81.9% specificity) than ultrasonography plus Doppler evaluation (70.3% sensitivity and 73.5% specificity). Quantitative elastography, assessed using the fat-to-lesion ratio, was a good discriminant for malignancy (AUROC = 0.93, p < 0.001). Our results pointed to an optimal threshold for malignancy of > 4.88; by using this threshold, the diagnostic reliability of the fat-to-lesion ratio was better than both ultrasonography and qualitative elastography (86.5% sensitivity and 90.4% specificity). Conclusion: Real time elastography is superior to ultrasonography in diagnosing malignant breast nodules. The evaluation of nodules using a fat-to-lesion ratio was a better discriminant for malignancy than qualitative elastography.

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“…Recently, color flow display technology in 3D 7 power Doppler US was developed to improve the visualization of small vessels in breast masses, and HDF 8 technology additionally provides high-definition images and allows for stronger detection of vascular signals to assess tumor vascularization. Compared with conventional 2D color imaging in Doppler US, 3D color flow and HDF technology facilitates superior imaging of the vascular morphology and better discrimination of malignant breast tumors, because of the limited transverse and longitudinal planes provided by diagnostic breast sonography (Carson et al 1997, Wright et al 1998, Lee et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of evaluating tumor vascularization using 3D power Doppler ultrasound with high-definition flow technology in the prediction of the response to neoadjuvant chemotherapy for T2 breast cancer: a preliminary report

et al. 2015

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Role of color and power doppler imaging in differentiating between malignant and benign solid breast masses

Abstract: Color (power) Doppler imaging is a valuable adjunct to conventional sonography in differentiating between malignant and benign breast lesions.

Cited by 84 publications

References 17 publications

Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy

Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

Effectiveness of evaluating tumor vascularization using 3D power Doppler ultrasound with high-definition flow technology in the prediction of the response to neoadjuvant chemotherapy for T2 breast cancer: a preliminary report

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