Role of Compact Node and Posterior Extension in Direction‐Dependent Changes in Atrioventricular Nodal Function in Rabbit

Reid, Marie Claude; Billette, Jacques; Khalifé, K.; Tadros, Rafik

doi:10.1046/j.1540-8167.2003.03382.x

Cited by 28 publications

(35 citation statements)

References 50 publications

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Section: Avn Conduction Curvesmentioning

confidence: 78%

“…According to the experimental findings, the AVN conduction curves demonstrate pronounced direction-dependent behavior 2,31 . Fig 9 shows the comparison of experimentally obtained (left panels) (modified from 31 ) and simulated (right panels) anterograde and retrograde recovery curves in the control and ablation cases plotted versus S1S2 intervals. The modification from the dependence on recovery time H1A2 to S1S2 (A1A2) interval was performed by shifting each conduction curve on its minimal conduction time (A1H1) value according to the formula A1A2 = H1A2 + A1H1 51,52 .…”

Section: Avn Conduction Curvesmentioning

confidence: 78%

“…Simulated anterograde recovery curve (Fig 9A, right panel) in the control case demonstrates a typical exponential-like rise with reducing pacing interval 11,12,31 with a pronounced bend and tilting at the point where conduction switches from the FP to SP with smooth change of the conduction curve from flat to steep without gap, which is typical for rabbit AVN 2,11,31 . At long S1S2 intervals, the SP conduction is overcome by the FP conduction (flat portion of the control curve, see also Fig 5A), while at short S1S2 intervals, excitation propagates through the SP only (Figs 5B and 6A) due to longer refractory period of the FP (Fig 3).…”

Section: Avn Conduction Curvesmentioning

confidence: 88%

“…The nodal effective refractory period (ERPN) is set as the longest S1S2 pacing interval that results in neither HB nor atrial response in the cases of atrial pacing (anterograde propagation) and HB pacing (retrograde propagation), respectively. FP ablation markedly increased conduction time in both anterograde 31,36 and retrograde 31 conduction cases. The ERPN was 94 ms for anterograde conduction and did not change after FP ablation (91±10 ms in 31 ).…”

Section: Avn Conduction Curvesmentioning

confidence: 92%

“…FP ablation markedly increased conduction time in both anterograde 31,36 and retrograde 31 conduction cases. The ERPN was 94 ms for anterograde conduction and did not change after FP ablation (91±10 ms in 31 ). For the retrograde conduction, the ERPN was 163 ms and also did not change after FP ablation (143±16 ms before and 149±14 ms after FP ablation in 31 ).…”

Section: Avn Conduction Curvesmentioning

confidence: 92%

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A compact multifunctional model of the rabbit atrioventricular node with dual pathways

Ryzhii¹,

Ryzhii²

2023

Preprint

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The atrioventricular node (AVN) is considered a "black box", and the functioning of its dual pathways remains controversial and not fully understood. In contrast to numerous clinical studies, there are only a few mathematical models of the node. In this paper, we present a compact, computationally lightweight multifunctional rabbit AVN model based on the Aliev-Panfilov two-variable cardiac cell model. The AVN model includes fast (FP) and slow (SP) pathways, primary pacemaking in the sinoatrial node, subsidiary pacemaking in the SP, and takes into account the asymmetry of coupling between model cells. At the same time, the model is accompanied by a visualization of electrical conduction in the AVN, revealing the interaction between SP and FP in the form of ladder diagrams. The AVN model demonstrates broad functionality, including normal sinus rhythm, AVN automaticity, filtering of high-rate atrial rhythms during atrial fibrillation and atrial flutter with Wenckebach periodicity, direction-dependent properties, and realistic anterograde and retrograde conduction curves in the control case and the cases of FP and SP ablation. To show the validity of the proposed model, we compare the simulation results with the available experimental data. Despite its simplicity, the proposed model can be used both as a stand-alone module and as a part of complex three-dimensional atrial or whole heart simulation systems and can help to understand some puzzling functions of AVN.

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Section: Avn Conduction Curvesmentioning

confidence: 78%

Section: Avn Conduction Curvesmentioning

confidence: 78%

Section: Avn Conduction Curvesmentioning

confidence: 88%

Section: Avn Conduction Curvesmentioning

confidence: 92%

Section: Avn Conduction Curvesmentioning

confidence: 92%

See 3 more Smart Citations

A compact multifunctional model of the rabbit atrioventricular node with dual pathways

Ryzhii¹,

Ryzhii²

2023

Preprint

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Frequency‐dependent Electrophysiological Remodeling of the AV Node by Hydroalcohol Extract of Crocus sativus L. (Saffron) During Experimental Atrial Fibrillation: The Role of Endogenous Nitric Oxide

Khori

Alizadeh

Yazdi

et al. 2011

Phytotherapy Research

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The study assessed the hydroalcohol extract effects of Crocus sativus L. (saffron) on (i) the basic and rate-dependent electrophysiological properties of the AV node, (ii) remodeling of the AV node during experimental atrial fibrillation (AF) and (iii) the role of nitric oxide (NO) in the effects of saffron on the AV node. Stimulation protocols in isolated AV node were used to quantify AV nodal recovery, facilitation and fatigue in four groups of rabbits (n = 8-16 per group). In addition, the nodal response to AF was evaluated at multiple cycle lengths and during AF. Saffron had a depressant effect on AV nodal rate-dependent properties; further, it increased Wenckebach block cycle length, functional refractory period, facilitation and fatigue (p < 0.05). A NO-synthase inhibitor (L-NAME) prevented the depressant effects of saffron on the AV node (p < 0.05). Saffron increased the zone of concealment in experimental AF (p < 0.05). The present research showed, for the first time, established electrophysiological remodeling of the AV node during AF by saffron. Saffron increased the AV nodal refractoriness and zone of concealment. These depressant effects of saffron were mediated by endogenous NO.

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Clinical Electrophysiological Mechanisms of Tachycardias Arising from the Atrioventricular Junction

Katritsis¹

2011

Cardiac Arrhythmias and Mapping Techniques

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Role of Compact Node and Posterior Extension in Direction‐Dependent Changes in Atrioventricular Nodal Function in Rabbit

Abstract: Direction-dependent properties of the AV node arise from those of the compact node-based fast pathway and posterior extension-based slow pathway. Normal AV node has bidirectional dual pathways.

Cited by 28 publications

References 50 publications

A compact multifunctional model of the rabbit atrioventricular node with dual pathways

A compact multifunctional model of the rabbit atrioventricular node with dual pathways

Frequency‐dependent Electrophysiological Remodeling of the AV Node by Hydroalcohol Extract of Crocus sativus L. (Saffron) During Experimental Atrial Fibrillation: The Role of Endogenous Nitric Oxide

Clinical Electrophysiological Mechanisms of Tachycardias Arising from the Atrioventricular Junction

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