Role of Complement Activation in a Model of Adult Respiratory Distress Syndrome

Abstract

A B S T R A C T The adult

Inert gas analysis of ventilation-perfusion matching during hemodialysis.

“…9 mongrel dogs weighing 20-24 kg were anesthetized with thiopental sodium (20-30 mg/kg), intubated with a cuffed endotracheal tube, and mechanically ventilated with room air at a tidal volume of 15 ml/kg and at a rate sufficient to maintain an arterial Paco2 of 32-36 torr. Thereafter, ventilation was kept at a constant minute volume.…”

Requirement and role of C5a in acute lung inflammatory injury in rats.

“…In the cobra venom factor (CVF) 1 model of lung injury, the CVF preparation must be able to activate not only C3 but also C5 (8), accordingly, hereditary absence of C5 protects the subject from lung injury (9). In vivo infusion of zymosan-activated plasma causes neutropenia (10,11), but little evidence of lung injury unless the activated plasma is repetitively infused (12). In experimental systems, interference with complement availability can be achieved either by complement blockade using recombinant soluble complement receptor-1 (sCR1) (13,14) or by the use of complement depletion procedures involving serial intraperitoneal injections of CVF (15,16).…”

Alternative complement pathway activation increases mortality in a model of burn injury in mice.

“…Forum. 31: 80. Received for publication 21 April 1982 and in revised form 17 August 1982. related syndromes (3)(4)(5)(6)(7)(8)(9)(10). In addition, complement activation is thought to be a contributing factor to cardiovascular collapse in septic shock (11)(12)(13)(14).…”