Role of conservative management of stones

Barba, Hector Sandoval; Darrad, Maitrey

doi:10.5152/tud.2020.20465

Cited by 2 publications

(2 citation statements)

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“…One review concerning asymptomatic calyceal stones revealed that average spontaneous stone passage rate and average requirement for surgical intervention were 18% and 20%, respectively. Also, 62% of patients remained asymptomatic on surveillance over a mean time of 4 years ( 48 ). Another systemic review included an asymptomatic kidney stone article over 25 years and indicated that stone size was not a reliable predictor of symptoms, but the need for intervention was linked to stone size.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Renal Stones and Primary Aldosteronism

Chang

et al. 2022

Front. Endocrinol.

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IntroductionThe association between primary aldosteronism (PA) and nephrolithiasis is still unclear. The hypercalciuria and hypocitraturia of PA patients might be the reason leading to recurrent calcium nephrolithiasis. This study aimed to evaluate the relationship between PA and renal stones, including stone size and density.Materials and MethodsFrom February 2010 to March 2021, we retrospectively collected 610 patients who presented to our medical center with hypertension history, and all these patients, suspicious of PA, had PA data survey. In total, 147 patients had kidney stone and were divided into 44 patients with essential hypertension as group 1 and 103 patients with PA as group 2. Pearson χ2 test and independent Student’s t-test were performed to examine the differences among variables.ResultsThe mean age was 54.4 ± 12.0 years in group 1 and 53.0 ± 11.1 years in group 2. The incidence rate of renal stones in the PA group was around 24%. No significant differences between the two groups were found for gender, systolic/diastolic blood pressure, duration of hypertension, diabetes mellitus history, and laterality of kidney stone; however, mean stone size was 4.0 ± 3.3 mm in group 1 and 6.5 ± 7.2 mm in group 2, with a significantly larger renal stone size noted in the PA group than that in the essential hypertension group (p = 0.004). Hounsfield unit (HU) density was higher in the PA group vis-à-vis the essential hypertension cohort, although this did not reach a significant difference (p = 0.204).ConclusionsOur study revealed that PA patients had a higher incidence rate of renal stones compared to that of the general population. Besides, the PA-related renal stones also presented as larger and harder than those of the essential hypertension group. Further investigation concerning the association between PA and renal stones is warranted.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Renal Stones and Primary Aldosteronism

Chang

et al. 2022

Front. Endocrinol.

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“…Stones can occur in any part of the urinary system, but their formation often initiates in the kidneys. Kidney stones tend to be located in the renal pelvis or calyces, and can be discharged to the ureter or bladder ( 26 , 27 ). Nearly all ureteral stones originate in the kidneys.…”

Section: Discussionmentioning

confidence: 99%

Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Levels as Early Markers of the Renal Function in Patients With Urinary Stone-Induced Hydronephrosis

et al. 2022

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IntroductionUrinary stones cause hydronephrosis, which leads to kidney function impairment. The serum creatinine level is frequently used as a marker of kidney function. However, in some patients with hydronephrosis, it does not reflect the kidney function changes in the early stages of kidney stone disease. Neutrophil gelatinase-associated lipocalin (NGAL) is a novel indicator of the kidney function. Previous NGAL-related research has focused on its role in acute kidney injury. This study aimed to determine the usefulness of NGAL as an early marker of the kidney function in patients with urinary stones and hydronephrosis.MethodsEighty-five patients with urinary stones who were admitted to the Shanghai Tenth People's Hospital (USP group) and 65 healthy volunteers (NC group) were recruited. Blood and urine samples collected from the study participants were evaluated using an enzyme-linked immunosorbent assay to determine the NGAL concentration. Data on the height, weight, age, medical history, and blood and urine findings were collected. Computed tomography data were collected from the USP group.ResultsCompared to in the NC group, NGAL levels were significantly elevated in the USP group (P < 0.001). However, no significant differences in the NGAL levels were observed among the USP group members with different degrees of hydronephrosis. Furthermore, no significant between-group differences in the creatinine level or the estimated glomerular filtration rate were observed. The areas under the receiver operating characteristic curves for the serum and urinary NGAL levels with hydronephrosis were 92.03 and 99.54%, respectively. The areas under the receiver operating characteristic curves for the serum and urinary NGAL levels with kidney stones were 85.05 and 91.89%, respectively.ConclusionNGAL is a sensitive indicator of hydronephrosis secondary to urinary stones.

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Role of conservative management of stones

Cited by 2 publications

References 34 publications

The Relationship Between Renal Stones and Primary Aldosteronism

The Relationship Between Renal Stones and Primary Aldosteronism

Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Levels as Early Markers of the Renal Function in Patients With Urinary Stone-Induced Hydronephrosis

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