2019
DOI: 10.1021/acs.jcim.8b00919
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Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5

Abstract: Background: The mitogen-activated protein kinase (MAPK) pathway is functionally generic and critical in maintaining physiological homeostasis and normal tissue development. This pathway is under tight regulation, which is in part mediated by dual-specific phosphatases (DUSPs), which dephosphorylate serine, threonine, and tyrosine residues of the ERK family of proteins. DUSP5 is of high clinical interest because of mutations we identified in this protein in patients with vascular anomalies. Unlike other DUSPs, … Show more

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Cited by 2 publications
(2 citation statements)
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References 33 publications
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“…As a nucleophilic catalytic group, Cys forms a bond with the phosphate group of the substrate, generating a complex that then reacts with protons of Asp or water molecules to form a phosphate cysteine intermediate. Hydrolysis of this intermediate then exposes the active site that can participate in the subsequent reaction …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…As a nucleophilic catalytic group, Cys forms a bond with the phosphate group of the substrate, generating a complex that then reacts with protons of Asp or water molecules to form a phosphate cysteine intermediate. Hydrolysis of this intermediate then exposes the active site that can participate in the subsequent reaction …”
Section: Introductionmentioning
confidence: 99%
“…Hydrolysis of this intermediate then exposes the active site that can participate in the subsequent reaction. 8 Proso millet peroxidase (PmPOD) is a type-b hemecontaining cationic peroxidase found in proso millet. It can induce RIPK1-and RIPK3-dependent necroptosis in HCT116 and HT29 cells by causing DNA double-strand breaks (DSBs).…”
Section: ■ Introductionmentioning
confidence: 99%