2001
DOI: 10.1046/j.1523-1755.2001.00009.x
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Role of contact system activation in hemodialyzer-induced thrombogenicity

Abstract: Our data challenge the common assumption that activation of the contact system with generation of FXIIa is the main trigger for coagulation and thrombus formation in hemodialysis. Only the negatively charged AN69 membrane with enhanced thrombogenicity strongly induced contact activation.

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Cited by 80 publications
(67 citation statements)
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“…Initially it was thought that clotting in the dialyzer was due to the deposition of plasma proteins on the dialyzer surface, in particular high-molecular-weight kininogen, prekallikrein and factor XII that are involved in contact activation of coagulation and the fibrinolytic system [13]. Clotting on dialyzer membranes is now thought to be more dependent upon activation of platelets and white blood cells, typically activated monocytes [14].…”
Section: Discussionmentioning
confidence: 99%
“…Initially it was thought that clotting in the dialyzer was due to the deposition of plasma proteins on the dialyzer surface, in particular high-molecular-weight kininogen, prekallikrein and factor XII that are involved in contact activation of coagulation and the fibrinolytic system [13]. Clotting on dialyzer membranes is now thought to be more dependent upon activation of platelets and white blood cells, typically activated monocytes [14].…”
Section: Discussionmentioning
confidence: 99%
“…The complement activation parameters (C3a and C5b-9) were much higher for BC compared with the other materials, for both 4 and 6 mm tubes. Cellulose is known to induce complement activation in hemodialysis membranes (Frank et al, 2001). The mechanisms underlying these results for BC are still unclear and require further investigation.…”
Section: Complement Activationmentioning
confidence: 99%
“…On the one hand, they can prevent the direct contact between blood and membrane to increase the biocompatibility of the dialysis system [11][12][13][14] , and on the other hand, accumulation of large amounts of proteins on the membrane may block the pores of the dialysis membrane, reducing the transfer capability. Besides, they will also lead to a variety of pathological and physiological reactions such as blood coagulation, activation of complement and fibrinolytic systems, and enhanced activity of inflammatory factors [15] . Thus, the removal of excessive adhered proteins on dialysis membranes, while maintaining blood compatibility, is an important issue.…”
Section: Introductionmentioning
confidence: 99%