Carbon dioxide emissions (CO
2
e) which is caused by energy use contributes to the global average surface temperature increase by 1.5 °C as compared to the mid-1800s which is causing a certain change in the climate and becoming an adverse effect on health and economy. The relationship between health status, CO
2
e, and energy use has yet to be thoroughly investigated in the top 20 highest emitting economies. The data from 2000 to 2019 is analyzed by using advanced techniques of cross-sectional augmented distributed lag (CS-DL) and cross-sectional augmented autoregressive distributed lag (CS-ARDL) which take into consideration crucial elements of panel data, namely dynamics, heterogeneity, and cross-sectional dependence. Moreover, cross-sectional augmented error correction method (CS-ECM) and the common dynamic process of the augmented mean group (AMG) are applied for robustness checks. The empirical findings revealed that (i) CO
2
e weakens the health status only in the short-run, whereas health expenditure improves the health status in the both short- and long-runs, while economic growth is not contributing to the health status in the both short- and long-runs; (ii) health expenditure and economic growth only help to mitigate CO
2
e in the long-run, whereas energy use causes CO
2
e in the both short- and long-runs; (iii) energy use causes high economic growth in the both short- and long-runs, whereas CO
2
e aids economic growth in the short-run but is extremely damaging to economic growth in the long-run, while in the both short- and long-runs health expenditure is not aiding the economic growth. This study provides policy recommendations on improving human health by advocating massive health expenditures, CO
2
e easing, promoting renewable energy use or low-emission energy, and steering the economy toward green economic growth.
Graphical abstract