Role of CT enterography in assessment of Crohn's disease activity: Correlation with histopathologic diagnosis

Mohamed, Ahmed Mostafa; Amin, Shimaa A.; El-Shinnawy, Maha A.; Elfouly, Amr; Baki, Aber Halim

doi:10.1016/j.ejrnm.2012.05.005

Cited by 5 publications

(8 citation statements)

References 20 publications

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“…Nineteen articles met all inclusion criteria and were included for further data extraction. CT was evaluated in 3 [ 16 – 18 ], MRI in 11 [ 19 – 29 ], US in 3 [ 30 – 32 ], and scintigraphy in 3 [ 18 , 33 , 34 ]. No articles evaluating PET-CT were found that met our criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Evaluation of the imaging tests was performed blinded from the reference test in 13 studies [ 17 , 18 , 21 , 22 , 24 – 30 , 33 , 34 ]. The reference test was performed blinded to the imaging results in 12 studies [ 16 , 17 , 19 , 21 , 24 , 26 – 30 , 33 , 34 ]. The remaining studies did not specify whether observers were blinded to other results [ 20 , 23 , 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…The remaining studies did not specify whether observers were blinded to other results [ 20 , 23 , 31 , 32 ]. Fifteen of the studies included patients prospectively [ 16 – 26 , 28 , 30 , 31 , 34 ]. Signalling questions for the QUADAS tool were answered with ‘yes’ in 78.9 % of cases (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…of patients included No. of patients in analysis Consecutive Age, mean (range) or mean ± SD Male/female ratio Patient spectrum Inclusion criteria Mao 2013 [ 17 ] CT 32 32 Y 30 (18–51) b 22:10 Known CD Suspected recurrence after ileocolic resection Mohamed 2012 [ 16 ] CT 26 26 ? 43.4 (19–69) 18:8 Known CD Referred to further assessment with CTE Kolkman 1996 [ 18 ] CT, SG 32 17 ?…”

Section: Resultsmentioning

confidence: 99%

“…Bowel preparation (fasting and/or laxatives) was used in eight studies (1 CT, 7 MRI) [ 17 , 21 – 26 , 28 ]. Luminal contrast medium was used in ten studies (3 CT, 7 MRI) [ 16 – 18 , 21 – 23 , 25 , 27 – 29 ], of which one used enteroclysis [ 27 ]. Intravenous contrast medium was used in 13 studies (2 CT, 11 MRI) [ 16 , 17 , 19 – 29 ].…”

Section: Resultsmentioning

confidence: 99%

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Grading of Crohn’s disease activity using CT, MRI, US and scintigraphy: a meta-analysis

et al. 2015

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PurposeTo assess the grading of Crohn’s disease activity using CT, MRI, US and scintigraphy.Materials and methodsMEDLINE, EMBASE and Cochrane databases were searched (January 1983–March 2014) for studies evaluating CT, MRI, US and scintigraphy in grading Crohn’s disease activity compared to endoscopy, biopsies or intraoperative findings. Two independent reviewers assessed the data. Three-by-three tables (none, mild, frank disease) were constructed for all studies, and estimates of accurate, over- and under-grading were calculated/summarized by fixed or random effects models.ResultsOur search yielded 9356 articles, 19 of which were included. Per-patient data showed accurate grading values for CT, MRI, US and scintigraphy of 86 % (95 % CI: 75–93 %), 84 % (95 % CI: 67–93 %), 44 % (95 % CI: 28–61 %) and 40 % (95 % CI: 16–70 %), respectively. In the per-patient analysis, CT and MRI showed similar accurate grading estimates (P = 0.8). Per-segment data showed accurate grading values for CT and scintigraphy of 87 % (95 % CI: 77–93 %) and 86 % (95 % CI: 80–91 %), respectively. MRI and US showed grading accuracies of 67–82 % and 56–75 %, respectively.ConclusionsCT and MRI showed comparable high accurate grading estimates in the per-patient analysis. Results for US and scintigraphy were inconsistent, and limited data were available.Key Points• CT and MRI have comparable high accuracy in grading Crohn’s disease.• Data on US and scintigraphy is inconsistent and limited.• MRI is preferable over CT as it lacks ionizing radiation exposure.Electronic supplementary materialThe online version of this article (doi:10.1007/s00330-015-3737-9) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Grading of Crohn’s disease activity using CT, MRI, US and scintigraphy: a meta-analysis

et al. 2015

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Clinical implication of radiologic complete remission on Crohn’s Disease: Compared with endoscopic remission

Kim

Kim²,

Koh³

et al. 2022

European Journal of Radiology

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A radiomics nomogram based on MSCT and clinical factors can stratify fibrosis in inflammatory bowel disease

Zeng,

Jiang,

Dai

et al. 2024

Sci Rep

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Intestinal fibrosis is one of the major complications of inflammatory bowel disease (IBD) and a pathological process that significantly impacts patient prognosis and treatment selection. Although current imaging assessment and clinical markers are widely used for the diagnosis and stratification of fibrosis, these methods suffer from subjectivity and limitations. In this study, we aim to develop a radiomics diagnostic model based on multi-slice computed tomography (MSCT) and clinical factors. MSCT images and relevant clinical data were collected from 218 IBD patients, and a large number of quantitative image features were extracted. Using these features, we constructed a radiomics model and transformed it into a user-friendly diagnostic nomogram. A nomogram was developed to predict fibrosis in IBD by integrating multiple factors. The nomogram exhibited favorable discriminative ability, with an AUC of 0.865 in the validation sets, surpassing both the logistic regression (LR) model (AUC = 0.821) and the clinical model (AUC = 0.602) in the test set. In the train set, the LR model achieved an AUC of 0.975, while the clinical model had an AUC of 0.735. The nomogram demonstrated superior performance with an AUC of 0.971, suggesting its potential as a valuable tool for predicting fibrosis in IBD and improving clinical decision-making. The radiomics nomogram, incorporating MSCT and clinical factors, demonstrates promise in stratifying fibrosis in IBD. The nomogram outperforms traditional clinical models and offers personalized risk assessment. However, further validation and addressing identified limitations are necessary to enhance its applicability.

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Role of CT enterography in assessment of Crohn's disease activity: Correlation with histopathologic diagnosis

Cited by 5 publications

References 20 publications

Grading of Crohn’s disease activity using CT, MRI, US and scintigraphy: a meta-analysis

Grading of Crohn’s disease activity using CT, MRI, US and scintigraphy: a meta-analysis

Clinical implication of radiologic complete remission on Crohn’s Disease: Compared with endoscopic remission

A radiomics nomogram based on MSCT and clinical factors can stratify fibrosis in inflammatory bowel disease

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