Role of Cu element in biomedical metal alloy design

Zhang, Erlin; Fu, Shuangcheng; Wang, Ruoxian; Li, Haixia; Liu, Ying; Ma, Zhiqiang; Liu, Guangkun; Zhu, Chenshun; Qin, Gaowu; Chen, Dafu

doi:10.1007/s12598-019-01245-y

Cited by 127 publications

(37 citation statements)

References 124 publications

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“…Cu electrode offers a better surface finish. Moreover, Cu exhibits special functions to biomedical alloys such as enhancing mechanical properties through solution strengthening, improves biocorrosion resistance and provides antibacterial properties [44]. Si powder was used in the dielectric to enhance machining properties.…”

Section: Methodsmentioning

confidence: 99%

On the Investigation of Surface Integrity of Ti6Al4V ELI Using Si-Mixed Electric Discharge Machining

et al. 2020

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Surface modification is given vital importance in the biomedical industry to cope with surface tissue growth problems. Conventionally, basic surface treatment methods are used which include physical and chemical deposition. The major drawbacks associated with these methods are excessive cost and poor adhesion of coating with implant material. To generate a bioactive surface on an implant, electric discharge machining (EDM) is a promising and emerging technology which simultaneously serves as machining and surface modification technique. Besides the surface topology, implant material plays a very important role in surgical applications. From various implant materials, titanium (Ti6Al4V ELI) alloy is the best choice for long-term hard body tissue replacement due to its superior engineering, excellent biocompatibility and antibacterial properties. In this research, EDM’s surface characteristics are explored using Si powder mixed in dielectric on Ti6Al4V ELI. The effect of powder concentration (5 g/L, 10 g/L and 20 g/L) along with pulse current and pulse on time is investigated on micro and nanoscale surface topography. Optimized process parameters having a 5 g/L powder concentration result in 2.76 μm surface roughness and 13.80 μm recast layer thickness. Furthermore, a nano-structured (50–200 nm) biocompatible surface is fabricated on the surface for better cell attachment and growth. A highly favourable carbon enriched surface is confirmed through EDS which increases adhesion and proliferation of human osteoblasts.

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Section: Methodsmentioning

confidence: 99%

On the Investigation of Surface Integrity of Ti6Al4V ELI Using Si-Mixed Electric Discharge Machining

et al. 2020

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“…For this reason, Cu is being investigated as an antibacterial element with increased frequency in thin films [21,22], ionic form [23,24], and in alloys [17,25,26]. In particular, Zhang et al [27] have investigated the addition of Cu in titanium and found that there are discrepancies in the literature regarding required copper content and the mechanisms causing bacterial reduction. While success in antibacterial applications has been achieved with copper, the molecular process of bacterial death is not clear.…”

Section: Introductionmentioning

confidence: 99%

Development of Antibacterial Ti-Cux Alloys for Dental Applications: Effects of Ageing for Alloys with Up to 10 wt% Cu

et al. 2019

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Peri-implantitis, a disease caused by bacteria, affects dental implants in patients. It is widely treated with antibiotics, however, with growing antibiotic resistance new strategies are required. Titanium-copper alloys are prospective antibacterial biomaterials, with the potential to be a remedy against peri-implantitis and antibiotic resistance. The aim of this study was to investigate Ti-Cux alloys, exploring how Cu content (up to 10 wt%) and ageing affect the material properties. Electron microscopy, X-ray diffraction, hardness testing, bacteriological culture, and electrochemical testing were employed to characterize the materials. It was found that alloys with above 3 wt% Cu had two phases and ageing increased the volume fraction of Ti2Cu. An un-aged alloy of 5 wt% Cu showed what could be Ti3Cu, in addition to the α-Ti phase. The hardness gradually increased with increased Cu additions, while ageing only affected the alloy with 10 wt% Cu (due to changes in microstructure). Ageing resulted in faster passivation of the alloys. After two hours the aged 10 wt% Cu alloy was the only material with an antibacterial effect, while after six hours, bacteria killing occurred in all alloys with above 5 wt% Cu. In conclusion, it was possible to tune the material and antibacterial properties of Ti-Cux alloys by changing the Cu concentration and ageing, which makes further optimization towards an antibacterial material promising.

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“…Metal Ion Inorganic Antibacterial Agents: Metal ions (e.g., Ag + , Cu 2+ , Zn 2+ , Co 2+ ) are widely used in a variety of metal ion-based antibacterial materials because of their broad-spectrum antibacterial properties and nonresistance to antibiotics such as antibacterial implants, [23,24] wound dressings, [25] water disinfection, [26] and a range of other antibacterial products. [27] At present, the use of silver ions for antibacterial applications is still a hot spot for researchers. For example, Yan et al used the electron-assisted reduction method to fix highly dispersed silver nanoparticles (Ag NPs) on aminated carbon nanotubes (Ag/A-CNT) with an average Ag NP size of 3.8 nm.…”

Section: 1 Inorganic Antibacterial Agentsmentioning

confidence: 99%

Antibacterial Hybrid Hydrogels

Cao

Luo

et al. 2020

Macromolecular Bioscience

136

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Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over the world. In view of the increased bacteria resistance caused by overuse or improper use of antibiotics, antibacterial biomaterials are developed as the substitutes for antibiotics in some cases. Among them, antibacterial hydrogels are attracting more and more attention due to easy preparation process and diversity of structures by changing their chemical cross‐linkers via covalent bonds or noncovalent physical interactions, which can endow them with various specific functions such as high toughness and stretchability, injectability, self‐healing, tissue adhesiveness and rapid hemostasis, easy loading and controlled drug release, superior biocompatibility and antioxidation as well as good conductivity. In this review, the recent progress of antibacterial hydrogel including the fabrication methodologies, interior structures, performances, antibacterial mechanisms, and applications of various antibacterial hydrogels is summarized. According to the bacteria‐killing modes of hydrogels, several representative hydrogels such as silver nanoparticles‐based hydrogel, photoresponsive hydrogel including photothermal and photocatalytic, self‐bacteria‐killing hydrogel such as inherent antibacterial peptides and cationic polymers, and antibiotics‐loading hydrogel are focused on. Furthermore, current challenges of antibacterial hydrogels are discussed and future perspectives in this field are also proposed.

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Role of Cu element in biomedical metal alloy design

Cited by 127 publications

References 124 publications

On the Investigation of Surface Integrity of Ti6Al4V ELI Using Si-Mixed Electric Discharge Machining

On the Investigation of Surface Integrity of Ti6Al4V ELI Using Si-Mixed Electric Discharge Machining

Development of Antibacterial Ti-Cux Alloys for Dental Applications: Effects of Ageing for Alloys with Up to 10 wt% Cu

Antibacterial Hybrid Hydrogels

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