Role of Curdlan Sulfate in the Binding of HIV‐1 gp120 to CD4 Molecules and the Production of gp120‐Mediated TNF‐α

Takeda-Hirokawa, Nanako; Neoh, Lian-pin; Akimoto, Hiroaki; Kaneko, Hiroshi; Hishikawa, Takashi; Sekigawa, Iwao; Hashimoto, Hiroshi; Hirose, Shunichi; Murakami, Tsutomu; Yamamoto, Naoki; Mimura, Toru; Kaneko, Yutaro

doi:10.1111/j.1348-0421.1997.tb01920.x

Cited by 27 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(29) A second wave of cytokine secretion in mixed cultures was preceded by the infection of placental macrophages with HIV-1. Several studies have shown that both the envelope glycoproteins and the Tat protein of HIV-1 can induce production of IL-1b, (52,53) IL-6, (54,55) and TNF-a (56,57) by signal transduction via the CD4 cell surface receptor and transactivation of cytokine gene promoters, respectively. Obviously, IL-1b, IL-6, and TNF-a secreted by HIV-1-infected macrophages may further increase the rate of virus production in HIV-1-infected cells.…”

Section: Discussionmentioning

confidence: 99%

Induction of HIV-1 Replication in Latently Infected Syncytiotrophoblast Cells by Contact with Placental Macrophages: Role of Interleukin-6 and Tumor Necrosis Factor-α

Bácsi

Csoma

Beck

et al. 2001

Journal of Interferon & Cytokine Research

View full text Add to dashboard Cite

The syncytiotrophoblast (ST) layer of the human placenta has an important role in limiting transplacental viral spread from mother to fetus. Although certain strains of human immunodeficiency virus type 1 (HIV-1) may enter ST cells, the trophoblast does not exhibit permissiveness for HIV-1. The present study tested the possibility that placental macrophages might induce replication of HIV-1 carried in ST cells and, further, that infected ST cells would be capable of transmitting virus into neighboring macrophages. For this purpose, we investigated HIV-1 replication in ST cells grown alone or cocultured with uninfected placental macrophages. The macrophage-tropic Ba-L strain of HIV-1, capable of entering ST cells, was used throughout our studies. We demonstrated that interactions between ST cells and macrophages activated HIV-1 from latency and induced its replication in ST cells. After having become permissive for viral replication, ST cells delivered HIV-1 to the cocultured macrophages, as evidenced by detection of virus-specific antigens in these cells. The stimulatory effect of coculture on HIV-1 gene expression in ST cells was mediated by marked tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release from macrophages, an effect caused by contact between the different placental cells. Results of this study suggest an interactive role for the ST layer and placental macrophages in the dissemination of HIV-1 among placental tissue. Data reported here may also explain why macrophage-tropic HIV-1 strains are transmitted preferentially during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Induction of HIV-1 Replication in Latently Infected Syncytiotrophoblast Cells by Contact with Placental Macrophages: Role of Interleukin-6 and Tumor Necrosis Factor-α

Bácsi

Csoma

Beck

et al. 2001

Journal of Interferon & Cytokine Research

View full text Add to dashboard Cite

show abstract

“…Gpl20 can induce several kinds of immune dysfunction observed in HIV-1-infected patients such as CD4 down-modulation on T cells, T-cell activation, and T-cell anergy (shown as human leukocyte antigen [HLA]-class II molecule expression on T cells, low production of mitogen-induced interleukin [IL]-2, and a weak response in the mixed lymphocyte reaction), polyclonal B-cell activation, and apoptotic death of CD4+ T cells (5,7,14,23,26,28,36,41,43,44). These immune abnormalities have been reported to be mediated by several cytokines, such as tumor necrosis factor (TNF)-a, IL-6, and IL-10 produced from gpl20-stimulated macrophages (7,23,26,28,36,41,43,44,46), and to be mediated by phosphorylation of protein tyrosine kinase p56lck in CD4+ cells induced by binding of HIV-1 envelope glycoprotein (19,21). Although such immunologie changes are seen with HIV-2 infection, they are less severe than would be expected with HIV-1 infection in similar crosssectional settings (29).…”

Section: Hiv Envelope Glycoproteinmentioning

confidence: 99%

Differences of HIV Envelope Protein between HIV-1 and HIV-2: Possible Relation to the Lower Virulence of HIV-2

Sekigawa¹,

Kaneko²,

Neoh³

et al. 1998

Viral Immunology

Self Cite

View full text Add to dashboard Cite

“…Curdlan has been reported to be a useful additive for a variety of food products, such as for yogurt stability improvement [5], noodles, sauces, frozen foods and packaged meats for texture improvement and stabilizing ability [6]. Curdlan and its derivatives have also been used as drug delivery vehicles [7] and for sustained release of drugs [8]. Curdlan sulfates has been shown to exhibit high anti-AIDS activity [9, 10] and strong inhibitory action on blood coagulation and hence can be used for the treatment of thrombosis [11].…”

Section: Introductionmentioning

confidence: 99%

Improved curdlan production with discarded bottom parts of Asparagus spear

et al. 2017

View full text Add to dashboard Cite

BackgroundThis work evaluated the improvement of curdlan production of Agrobacterium sp. ATCC 31749 by using culture medium containing juice of discarded bottom part of green Asparagus spear (MJDA). Curdlan production was carried out using Agrobacterium sp. ATCC 31749 in flasks with different volumes of MJDA and its non-juice-adding control (CK) incubated in shaker at 30 °C, 200 rpm rotation for 168 h.ResultsAll MJDA media increased Agrobacterium sp. ATCC 31749 cell mass and enhanced the cells’ ability to utilise sucrose, the carbon source for curdlan biosynthesis, and thereby produced higher concentration of curdlan than CK which is used for commercial production of curdlan. After 168 h of fermentation, 10% MJDA produced 40.2 g/l of curdlan whiles CK produced 21.1 g/l. Curdlan production was increased by 90.4% higher in 10% MJDA than CK. Curdlan produced by 10% MJDA contains 1.2 and 1.5 µg/ml of Asparagus flavonoids and saponins respectively as additives which have wide range of health benefits. The mass of sucrose needed to produce 1.0 g curdlan by Agrobacterium sp. ATCC 31749 in CK is 1.7-fold more than in 10% MJDA.ConclusionThe results strongly revealed that 5–10% MJDA is a good curdlan fermentation media which increase curdlan production yield with cheaper cost of production and simultaneously reduce environmental waste resulting from the large scaled discarded bottom parts of green Asparagus spear during Asparagus production.

show abstract

Role of Curdlan Sulfate in the Binding of HIV‐1 gp120 to CD4 Molecules and the Production of gp120‐Mediated TNF‐α

Cited by 27 publications

References 23 publications

Induction of HIV-1 Replication in Latently Infected Syncytiotrophoblast Cells by Contact with Placental Macrophages: Role of Interleukin-6 and Tumor Necrosis Factor-α

Induction of HIV-1 Replication in Latently Infected Syncytiotrophoblast Cells by Contact with Placental Macrophages: Role of Interleukin-6 and Tumor Necrosis Factor-α

Differences of HIV Envelope Protein between HIV-1 and HIV-2: Possible Relation to the Lower Virulence of HIV-2

Improved curdlan production with discarded bottom parts of Asparagus spear

Contact Info

Product

Resources

About