Role of cytokines in altitude-associated preeclampsia

Dávila, R. Daniela; Julian, Colleen G.; Browne, Vaughn A.; Toledo-Jaldin, Lillian; Wilson, Megan J.; Rodríguez, Armando; Vargas, Enrique; Moore, Lorna G.

doi:10.1016/j.preghy.2011.11.001

Cited by 8 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, both TNF-␣ and IL-6 were lower in Andeans and Europeans at high altitude than at low altitude (207). At high altitude, preeclamptic Andeans had elevated proinflammatory cytokines IL-6 and IL-8 compared with normotensive counterparts, whereas proinflammatory TNF-␣ and anti-inflammatory IL-10 were similar in both normotensive and preeclamptic women (205). Birth weight was negatively associated with IL-6 levels.…”

Section: Inflammation/cytokinesmentioning

confidence: 83%

Gestational Hypoxia and Developmental Plasticity

Ducsay

Goyal

Pearce

et al. 2018

Physiological Reviews

145

View full text Add to dashboard Cite

Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is multidimensional involving complicated intracellular networks concerned with the transduction of hypoxia-induced responses. Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. Hypoxia during gestation impacts both the mother and fetal development through interactions with an individual's genetic traits acquired over multiple generations by natural selection and changes in gene expression patterns by altering the epigenetic code. Changes in the epigenome determine "genomic plasticity," i.e., the ability of genes to be differentially expressed according to environmental cues. The genomic plasticity defined by epigenomic mechanisms including DNA methylation, histone modifications, and noncoding RNAs during development is the mechanistic substrate for phenotypic programming that determines physiological response and risk for healthy or deleterious outcomes. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis on the uteroplacental circulation, heart development, cerebral circulation, pulmonary development, and the hypothalamic-pituitary-adrenal axis and adipose tissue. The complex molecular and epigenetic interactions that may impact an individual's physiology and developmental programming of health and disease later in life are discussed.

show abstract

Section: Inflammation/cytokinesmentioning

confidence: 83%

Gestational Hypoxia and Developmental Plasticity

Ducsay

Goyal

Pearce

et al. 2018

Physiological Reviews

145

View full text Add to dashboard Cite

show abstract

“…menyebabkan preeklampsia. 4 Interleukin 6 telah diketahui berhubungan dengan stres oksidatif dan disfungsi endotel dan memiliki peranan dalam patogenesis preeklampsia. Disfungsi endotel dan peningkatan permeabilitas merupakan jalur utama pada patofisiologi preeklampsia.…”

Section: Pendahuluanunclassified

“…Sitokin inflamasi merupakan activator pada vaskular endhothelium dan merupakan mediator penting pada proses disfungsi endotelelial yang menyebabkan preeklampsia. 4 Disfungsi sel endothelial terjadi melalui aktivasi dari produksi protein sel permukaan yang memediasi keikutsertaan sel-sel inflamasi. Proses ini dimediasi oleh sitokin yang diproduksi oleh sel inflamasi dan mengaktivasi sel-sel endothelial.…”

Section: Pendahuluanunclassified

Perbedaan Kadar Interleukin 6 Serum dan Kadar HsCrp Pada Ibu Hamil Preeklampsia

Burhanuddin,

Syahrianti,

Afrianty

2021

woh

View full text Add to dashboard Cite

Kadar Interleukin 6 (IL-6) dan kadar hsCRP( High sensitive C Reaktif Protein) meningkat pada ibu hamil preeklampsia. Peningkatan kadar hsCRP diinduksi oleh IL-6. Peningkatan kadar keduanya berhubungan dengan preeklampsia pada ibu hamil. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IL6 serum dan kadar hsCRP pada ibu hamil preeklampsia dan ibu hamil normal. Metode penelitian menggunakan desain cross sectional study yang melibatkan 84 orang ibu hamil (42 kehamilan preeklampsia dan 42 kehamilan normal). Data umur, IMT dan darah vena diambil dari responden dan kadar hsCRP, kadar IL6 diukur dengan metode ELLISA. Kehamilan preeklampsia ditentukan oleh dokter spesialis kandungan yang bertugas di rumah sakit dengan kriteria preeklampsia bila tekanan darah sistolik ≥140 mmHg dan tekanan darah diastolik ≥90 mmHg dengan proteinuria ≥300 mg/l pada pengambilan urine 24 jam. Layer analisis test digunakan untuk membandingkan karakterisitik subyek pada kelompok kehamilan preeklampsia dan kelompok kehamilan normal. Sementara uji one way anova digunakan untuk melihat perbedaan kadar IL6, kadar hsCRP pada ibu hamil preeklampsia dan ibu hamil normal. Hasil penelitian menunjukan kadar IL6 lebih tinggi pada ibu hamil preeklampsia dibanding kelompok kehamilan normal (beda rata-rata= 308.8 dengan nilai p=0.000 lebih kecil 0.005 dan perbedaan rata-rata kadar IL6 serum antara kelompok ibu hamil preeklampsia berat dengan ibu hamil normal beda rata-rata = 295.5 dengan nilai p=0.000 lebih kecil 0.005) dan kadar hsCRP juga lebih tinggi pada ibu hamil preeklampsia dibanding pada kelompok ibu hamil normal (beda rata-rata = 0.85 dengan nilai p=0.001lebih kecil 0.005).

show abstract

“…Based on epidemiologic research, high maternal body mass index (BMI) ( Thadhani et al 1999 ), polycystic ovary syndrome ( Palomba et al 2015 ), preexisting hypertension, primiparity ( Hernández-Díaz et al 2009 ), family history ( Boyd et al 2013 ; Esplin et al 2001 ; Skjærven et al 2005 ), and a history of PE ( Boyd et al 2013 ) are recognized risk factors. There is also evidence that risk is associated with short stature ( Basso et al 2004 ), high altitude ( Dávila et al 2012 ), subfecundity ( Basso et al 2003 ), and long inter-pregnancy interval ( Basso et al 2001 ; Skjærven et al 2002 ). Maternal cigarette smoking, a risk factor for many adverse reproductive outcomes, is well known to be associated with lower risk of PE ( Conde-Agudelo et al 1999 ; Engel et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Season of Conception, Smoking, and Preeclampsia in Norway

Weinberg

Shi

Basso

et al. 2017

Environ Health Perspect

View full text Add to dashboard Cite

Background:Preeclampsia (PE) is a dangerous and unpredictable pregnancy complication. A seasonal pattern of risk would suggest that there are potentially preventable environmental contributors, but prior analyses have not adjusted for confounding by PE risk factors that are associated with season of conception.Methods:Seasonal effects were modeled and tested by representing each day of the year as an angle on a unit circle and using trigonometric functions of those angles in predictive models, using “harmonic analysis.” We applied harmonic Cox regression to model confounder-adjusted effects of the estimated day of the year of conception on risk of PE for births from the Medical Birth Registry of Norway for deliveries between 1999 and 2009. We also examined effect measure modification by parity, latitude (region), fetal sex, and smoking.Results:In adjusted models, PE risk was related to season, with higher risk in spring conceptions and lower risk in autumn conceptions, with a risk amplitude (maximum compared with minimum) of about 20%. The pattern replicated across subpopulations defined by parity, latitude (region), fetal sex, and smoking.Conclusions:These results suggest that there is a seasonal driver for PE, with effects that are not modified by parity, latitude, fetal sex, or smoking. https://doi.org/10.1289/EHP963

show abstract

Role of cytokines in altitude-associated preeclampsia

Cited by 8 publications

References 35 publications

Gestational Hypoxia and Developmental Plasticity

Gestational Hypoxia and Developmental Plasticity

Perbedaan Kadar Interleukin 6 Serum dan Kadar HsCrp Pada Ibu Hamil Preeklampsia

Season of Conception, Smoking, and Preeclampsia in Norway

Contact Info

Product

Resources

About