Role of cytomegalovirus in sensorineural hearing loss of children: A case–control study Tehran, Iran

Cytomegalovirus and Toxoplasma Gondii: Common Causes of Profound Sensori Neural Hearing Loss in Children with Cochlear Implant Surgery in a Highly Immune Population: Tehran; Iran

“…Present findings are very close to other studies upon SNHL children (and normal controls) in our center (11,25); positive CMV-IgM & IgG was observed in 23% of cases vs. 34.7% of controls; and 51% of cases vs. 72.6% controls, respectively. Recent CMV infection was higher in the SNHL cases (P-value = 0.000) but previously, there was higher immunity (CMV- Negative -Toxo IgG 5.8 months --IgG) in controls (P value = 0.001).…”

“…Recent CMV infection was higher in the SNHL cases (P-value = 0.000) but previously, there was higher immunity (CMV- Negative -Toxo IgG 5.8 months --IgG) in controls (P value = 0.001). Mean age of cases with recent infection (positive IgM) was 40 months; and 35 months for cases with previous immunity (positive IgG) probably due to the transplacentel immunity which waned after 4 months [11]. These results differ from the previous (2006)(2007)(2008) serological study in 11 idiopathic type of SNHL (mean age; 32 +28 months) [12] and positive CMV-IgG in 100% of cases (previous immunity), none had recent infection (positive, IgM) [12] Yamamoto et al, described newborns with positive saliva CMV-DNA in the first 2 weeks of life, a prospective follow-up study was conducted to monitor hearing outcome [5].…”

Ear, nose and throat manifestation of viral systemic infections in pediatric patients

“…The hypoacusia that establishes itself is sensorineural, almost always bilateral, and profound, generally regarding acute tones. Symptomatic newborns have a mortality rate of up to 30% and 70-90% of those who survive have neurological deficits such as hearing loss, mental retardations and visual disturbances [8][9][10]. A vaccine for CMV is still under research.…”

Risk of sensorineural hearing loss in infants with abnormal head size

“…[8,9,[20][21][22] Viral infections in pregnancy have devastating effects during the critical period of the embryonic development of the inner ear especially around the fifth to the eighth week of gestation. [22] However, the relative contributions of these factors particularly the role of infections in this retrospective study could not be ascertained.…”

“…Congenital/postnatal CMV has been extensively reported as a cause of microcephaly as well as unilateral, bilateral, fluctuating, progressive, and late-onset hearing loss in both developed and developing countries. [9,20,21] In fact, CMV is the most prominent infectious cause of hearing loss just as hearing loss is reputed as the most common sequelae in both symptomatically and asymptomatically infected infants. It is therefore not unlikely that the ubiquitous CMV virus albeit seldom diagnosed routinely in this study population would be a major contributor to the observed association as in comparable countries.…”