Role of Dentinal Carious Lesions in the Pathogenesis of Oral Candidiasis in Hiv Infection

Jacob, Lisa S.; Flaitz, Catherine M.; Nichols, C. Mark; Hicks, M J

doi:10.14219/jada.archive.1998.0176

Cited by 45 publications

(36 citation statements)

References 19 publications

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“…However, a very strong association was observed with the caries status, even after adjusting for other predictors. Carious lesions are known reservoirs for yeasts and have been established as risk factors in oral colonization (Cerqueira et al, 2010;Jacob et al, 1998). Oral prostheses are similar reservoirs for oral colonization with yeasts, and our findings confirmed this, as all denture wearers were yeast-positive.…”

Section: Our Observations With Regard To Cd4supporting

confidence: 86%

Oral Candida colonization in HIV-positive women: associated factors and changes following antiretroviral therapy

Owotade

Patel

Ralephenya

et al. 2013

Journal of Medical Microbiology

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There is a paucity of information about the factors associated with oral colonization with Candida species and the changes associated with antiretroviral (ARV) therapy. This study investigated the role of ARV therapy and other factors in a study population. Relevant clinical and laboratory information was obtained and oral rinse specimens were tested for yeast identification. The findings were compared with previous data from the same clinic before ARV therapy was available. Of 197 patients, 117 (59.4 %) were colonized. Candida albicans was the dominant species (71 %) and Candida dubliniensis was the most frequent non-albicans Candida. The colonized group had a higher rate of concurrent tuberculosis (TB) infection (77.4 % compared with 56 % in the non-colonized patients, P50.03) and a lower median CD4+ count (346.5 cells . Participants not on ARV therapy and those having oral prosthesis were all colonized (P50.003 and P50.022, respectively). The oral Candida count was negatively correlated with the CD4 + count in participants on ARV therapy (P50.006). Associated factors using logistic regression were dental caries (odds ratio51.30; 95 % confidence interval51.07-1.60] and diabetes mellitus (odds ratio55.52; 95 % confidence interval51.68-18.12). The colonization rate was higher (81.3 %) as well as the yeast count before ARV therapy was available, while the prevalence of C. dubliniensis was found to have increased from 6.3 to 11 %. Dental caries, diabetes mellitus, oral prostheses and TB infection were associated with oral colonization. The colonization rate, variety and yeast counts declined with ARV therapy.

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Section: Our Observations With Regard To Cd4supporting

confidence: 86%

Oral Candida colonization in HIV-positive women: associated factors and changes following antiretroviral therapy

Owotade

Patel

Ralephenya

et al. 2013

Journal of Medical Microbiology

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“…This reduction could be probably due to the remotion of Candida colonization sites as proposed by Jacob et al 5 . A previous study analyzing the effect of extensive operative and restorative dental care on the levels of salivary mutans streptococci and lactobacilii in children observed a significant reduction of these microorganisms 27 .…”

Section: Discussionmentioning

confidence: 81%

“…This procedure can create conditions for the improvement of oral health. In fact, Jacob et al 5 , studying candidosis in HIV-infected patients, concluded that the elimination of carious dentine promotes the reduction of Candida colonization sites, reducing the risk of infections caused by these yeasts.…”

Section: Discussionmentioning

confidence: 99%

Effects of oral environment stabilization procedures on counts of Candida spp. in children

Rego

Koga-Ito

Jorge

2003

Pesqui. Odontol. Bras.

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ABSTRACT:The effects of oral environment stabilization procedures on counts of Candida spp. have rarely been discussed, and no conclusive results are found in the literature. The aim of this study was thus to ascertain the effects of oral environment stabilization procedures with glass ionomer and zinc oxide-eugenol cements on counts of Candida spp. in the oral cavity of children. For this purpose, oral rinses of sterile phosphate-buffered saline were initially collected from 30 boys and 30 girls, positive for Candida in the saliva and aged from 4 to 10 years. Data on the initial quantity of CFU/ml of Candida were obtained. Then, the children were randomly divided into two groups and oral environment stabilization procedures were performed using zinc oxide-eugenol cement or glass ionomer cement. One week after the procedures were performed, oral rinses were collected again and final Candida counts were obtained. An expressive reduction in Candida counts was observed in both groups. The zinc oxide-eugenol and glass ionomer cements were efficient in the reduction of Candida counts and statistically significant differences were observed between initial and final counts in both groups. Considering the percentage of reduction, the zinc oxide-eugenol cement presented more favorable results, with a reduction of 70%. A reduction of 46% was observed with the use of the glass ionomer cement. According to the obtained results, we concluded that oral environment stabilization procedures were efficient in reducing Candida spp. counts, especially when the zinc oxide-eugenol cement was employed. DESCRIPTORS:Candida; Zinc oxide-eugenol cement; Glass ionomer cement. RESUMO:O efeito da adequação de meio sobre contagens de Candida spp. na cavidade bucal tem sido pouco discutido e nenhum resultado conclusivo foi encontrado na literatura. Desse modo, o objetivo do presente trabalho foi verificar os efeitos da adequação de meio bucal, utilizando cimento de óxido de zinco e eugenol e cimento de ionômero de vidro, sobre contagens desses microorganismos em crianças. Foram coletados enxágües bucais de 30 meninos e 30 meninas com idades entre quatro e dez anos, positivos para Candida na saliva, obtendo-se a contagem inicial. As crianças foram divididas ao acaso em dois grupos e procedeu-se à adequação de meio utilizando um dos cimentos a serem testados. Uma semana depois, novo enxágüe bucal foi coletado, obtendo-se, dessa forma, a contagem final de Candida spp. Uma redução expressiva nas contagens foi observada em ambos os grupos. Os dois materiais testados foram eficazes na diminuição das contagens de Candida, e diferenças estatisticamente significantes foram observadas entre as contagens inicial e final nos dois grupos. Considerando o percentual de redução, o cimento de óxido de zinco e eugenol apresentou resultados mais favoráveis, promovendo uma redução de 70%, ao passo que para o cimento de ionômero de vidro esse valor foi de 46%. De acordo com os resultados obtidos, concluiu-se que a adequação de meio é um procedimento eficaz na red...

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“…The involvement of in caries has been widely researched through both and studies [1][2][3][4][5]. Because is the yeast spp.…”

Section: Introductionmentioning

confidence: 99%

Molecular and Histological Association Between Candida albicans from Oral Soft Tissue and Carious Dentine of HIV-Positive Children

Blignaut

Heerden

2015

Mycopathologia

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Abstractand caries are frequently investigated among healthy and immunosuppressed individuals. The objective of this study was to demonstrate the presence of on both oral soft and hard tissue and to investigate, at molecular level, the genetic subtype of the organism from the two oral sites. Tongue swabs and dentine scrapings from 362 HIV-positive children, referred for extraction of carious primary teeth, were cultured on CHROMagar and identified to species level with ID32C. Histological staining of extracted carious teeth was also done. In patients with positive cultures from both the tongue and carious dentine, DNA fingerprinting of such paired isolates were performed, using Southern blot hybridisation with the Ca3 probe. Yeasts were cultured from the tongue of 151 (41.7%) individuals and 57 (37.7%) simultaneously yielded positive cultures from carious dentine. Nine different yeast spp. were identified from the tongue using the ID32C commercial system but was the only species recovered from carious dentine and histological investigation demonstrated fungal elements penetrated into the dentine and not limited to superficial debris on the floor of the cavity. Twelve of 13 paired isolates of revealed identical fingerprinting patterns. The findings from this study demonstrated that in a particular individual, the same genetic subtype of was capable of colonizing both oral soft tissue and carious dentine. This renders carious teeth a constant source, or reservoir, of potentially infectious agents and, particularly among immunosuppressed individuals, should therefore not be left unattended.

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Role of Dentinal Carious Lesions in the Pathogenesis of Oral Candidiasis in Hiv Infection

Cited by 45 publications

References 19 publications

Oral Candida colonization in HIV-positive women: associated factors and changes following antiretroviral therapy

Oral Candida colonization in HIV-positive women: associated factors and changes following antiretroviral therapy

Effects of oral environment stabilization procedures on counts of Candida spp. in children

Molecular and Histological Association Between Candida albicans from Oral Soft Tissue and Carious Dentine of HIV-Positive Children

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