Role of Depressive Symptoms in Coronary Artery Spasm

Yoon, Sujung; Kim, Tae Suk; Seung, Ki Bae; Kim, Pum Joon; Lee, Chul; Jun, Tae-Won; Lee, Chang Uk; Lyoo, In Kyoon

doi:10.1159/000276379

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…The lack of any association with biological risk factors of CHD or its surrogates contradicts assumptions of a direct link of type D with CHD mediated by inflammation and endothelial dysfunction. This picture differs from depression [46,47,48,49,50]. While not entirely consistent, associations of depression with endothelial dysfunction [45], biomarkers of inflammation [51], coagulation [52,53] and myocardial stress [54] have repeatedly been described.…”

Section: Discussionmentioning

confidence: 99%

Type D Personality as a Cardiovascular Risk Marker in the General Population: Results from the Gutenberg Health Study

Beutel¹,

Wiltink²,

Till³

et al. 2012

Psychother Psychosom

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Background: Type D personality is considered as an independent risk factor for morbidity and mortality in cardiovascular patients and a vulnerability factor for distress in the general population. Because representative community studies are rare, we sought to determine the prevalence of type D personality and its relationship with demographic characteristics, different features of mental disorders, cardiovascular risk factors, health behavior, endothelial function and cardiovascular biomarkers in the general population. Methods: The prevalence of type D personality and its correlates were analyzed cross-sectionally in a population-based sample of 5,000 Mid-Europeans aged 35–74 years from the Gutenberg Health Study. Results: The prevalence of type D personality was 22.2% without remarkable differences in sex distribution. Type D subjects were characterized by lower socioeconomic status, lack of a partnership, increased depression, anxiety, depersonalization and health care utilization. Despite its strong association with mental disorders, type D personality emerged as psychometrically distinct. Although type D personality was independently associated with coronary heart disease (OR = 1.54, p = 0.044), no associations with traditional cardiovascular risk factors were found independently from depression or anxiety. Conclusions: Although type D personality is strongly associated with depression, anxiety, impaired mental and somatic health status, and increased health care utilization, the type D construct seems to comprise dysfunctional personality patterns not covered by depression and anxiety scales. Beyond these associations, the pathways of the cardiotoxic impact of type D personality remain to be elucidated. There is a need for prospective population studies on potential links between type D personality and cardiac disease.

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Section: Discussionmentioning

confidence: 99%

Type D Personality as a Cardiovascular Risk Marker in the General Population: Results from the Gutenberg Health Study

Beutel¹,

Wiltink²,

Till³

et al. 2012

Psychother Psychosom

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show abstract

“…Aside from tobacco use, there was no history of cocaine or methamphetamines consumption in our patients. Depression, present in the history of our patient, is considered as an independent factor of occurrence of coronary spasm with a dose-effect relationship [12] and more generally of cardiovascular events [13]. Serious management of this aspect as well as of the other psycho-social factors is an integral part of the prevention of recurrences.…”

Section: Discussionmentioning

confidence: 79%

Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

Ndao¹,

Ka²,

Dia³

et al. 2020

WJCD

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Coronary artery vasospasm is an infrequent cause of acute coronary syndrome (ACS). A 50-year-old female developed persistent chest discomfort related to anterior STEMI. After an unsuccessful thrombolysis attempt, due to delay concern, the patient was then sent to the catheterization laboratory for rescue PCI. The coronary angiogram revealed a TIMI 3 flow proximal LAD significant stenosis with spastic appearance of the coronary arteries which has improved after intracoronary nitrates administration. Optical Coherence Tomography (OCT) excluded coronary artery dissection and haematoma also revealed thrombus on moderate atherosclerotic plaque. The patient was then pain-free; she was managed medically and discharged after few days of monitoring. Three weeks later, she developed transient chest pain with ST segment elevation while cycling during rehabilitation program. Provocation test by Ergonovine was positive with complete occlusion of proximal RCA (right coronary artery) complicated by transient complete heart block and shock. She was stabilized with 7 mg of intracoronary nitrates injection. She was discharged after close monitoring with calcium channel blocker and tobacco cessation. ACS may complicate prolonged coronary artery vasospasm making the diagnosis challenging. OCT may help understand ACS mechanism and exclude spontaneous coronary artery dissection. Provocation test is crucial for confirmation.

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“…31 Depression also has a dose-response association with coronary artery spasm. 42 Coronary vasospasm is a common cause of MINOCA. Coronary vasospasm, including epicardial spasm and microvascular spasm, was found in 46% of patients with MINOCA undergoing provocative testing.…”

Section: Coronary Artery Spasmmentioning

confidence: 99%

Do Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries Have Similar Prognosis Compared to Ones with MI-CAD?

et al. 2022

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Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide and it is primarily caused by acute plaque disruption and coronary occlusion. Recent studies suggest that myocardial infarction with non-obstructive coronary arteries (MINOCA) also occurs but the underlying mechanisms have not been fully understood until recently. The evidence also suggests that the clinical outcomes of patients presenting with MINOCA are similar to AMI patients with obstructive coronary artery disease (MI-CAD), including all-cause mortality and major adverse cardiovascular events. The present narrative review considers the risk factors, pathological changes, and outcomes associated with MINOCA and compares them with MI-CAD.

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Role of Depressive Symptoms in Coronary Artery Spasm

Cited by 5 publications

References 23 publications

Type D Personality as a Cardiovascular Risk Marker in the General Population: Results from the Gutenberg Health Study

Type D Personality as a Cardiovascular Risk Marker in the General Population: Results from the Gutenberg Health Study

Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

Do Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries Have Similar Prognosis Compared to Ones with MI-CAD?

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