Role of Dermatoglyphics as a Diagnostic Tool in Medical Disorders

Kumar, Santhosh

doi:10.19070/2377-8075-21000462

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…1 Globally, oral squamous cell carcinoma (OSCC) ranks eighth in the cancer incidence and third most common malignancy in South-central Asia with the epidemiologic variations between different geographic regions. 2,3 Development of OSCC is associated with several etiological factors, namely, tobacco, alcohol, diet and nutrition, human papillomavirus infection, radiation, ethnicity, familial and genetic predisposition, oral thrush, immunosuppression, use of mouthwash, syphilis, dental factors, occupational risks, and mate. 4,5 Current treatment modalities for OSCC include chemo/radiotherapy, radical ablative surgery, targeted therapies with epidermal growth factor receptors inhibitors, and cyclooxygenase-2 inhibitors, and photodynamic therapy have led to the major problems related to non-specific cell death.…”

Section: Introductionmentioning

confidence: 99%

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

2021

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Sesamol is the main constituent of sesame seed oil and is obtained from Sesamum indicum. Oral squamous cell carcinoma (OSCC) is one of the most common neoplasms affecting the oral cavity. In this study, we investigated the cytotoxic potentials of sesamol on human oral squamous carcinoma (SCC-25) cells. Human oral squamous carcinoma cells were treated with different concentrations (62.5, 125, and 250 μM/mL) of sesamol for 24 h. Cytotoxicity was analyzed by 3- (4, 5- dimethylthiazol -2- yl) -2, 5-diphenyltetrazolium bromide (MTT) assay. Intracellular reactive oxygen species (ROS) expression was investigated by dichloro-dihydro-fluorescein diacetate assay. Apoptosis-related morphology was analyzed by acridine orange/ethidium bromide staining. Caspase-9 expression was analyzed by confocal microscopic double immunofluorescence staining. Mitochondrial apoptosis-related markers are analyzed using qPCR. Sesamol treatment caused a significant cytotoxic effect in OSCC cells. Sesamol-induced cytotoxic effect was associated with intracellular ROS generation. Sesamol treatments induced a significant increase in the early and late apoptotic cells. This treatment also induced caspase-9 expression in OSCC cells. Sesamol treatments caused downregulation of Harvey rat sarcoma viral oncogene homolog (HRAS) expression at protein and gene levels. Sesamol treatment modulates intrinsic apoptotic marker gene expression in OSCC cells. Overall results confirm the anti-cancer potential of sesamol and it seems to be a promising candidate for OSCC.

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Section: Introductionmentioning

confidence: 99%

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

2021

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“…These findings are similar to previously reported studies in Kenyan and Tanzanian populations. The distribution of the frequencies of different finger patterns may be generalized among major population groups as follows: Whorls: Mongoloids (47%) > American Indians (43%) > Europeans (36%) > Africans (27%), Loops: Africans (64%) > Europeans (60%) > American Indians (52%) > Mongoloids (51%), Arches: Africans (9%) > American Indians (5%) > Europeans (4%) > Mongoloids (2%) as documented 31 , similar to current findings where the results showed a high frequency of loop patterns in three villages located in Irruan Clan, Boki LGA, Cross River State. Loop patterns were documented by researchers, followed by the arches, then the whorls in the male subjects 29,32 in different Nigerian ethnic groups which are slightly different from the trend of Loop >Whorls > Arches obtained in this study.…”

Section: Discussionmentioning

confidence: 99%

Digito-Palmar Dermatoglyphic Patterns among Natives of Irruan in Boki Local Government Area of Cross River State Nigeria

Umoyen,

Akpan,

Sunday

et al. 2023

Trends Med. Res

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Background and Objective:The uniqueness of digital-palmar dermatoglyphics patterns has made it possible for anthropological studies on ethnic differences and heritability among individuals. It has been widely studied, varying across different ethnic populations. This present study investigated the digitopalmar dermatoglyphic patterns among natives from the Irruan Clan, Boki. Materials and Methods: A total of 52 natives, were recruited and their prints were collected by conventional ink method, read using a hand magnifying lens. Analyses were performed using descriptive statistics, student t-test, chi-squared Test and significant set at 5%. Results: The loop, whorl, arch and compound distribution of fingerprint patterns were 40.4, 26.9, 19.2 and 13.5%, respectively. The frequency of loop patterns in males and females is 25% (13) and 15.4% (8), respectively. The mean total ridges count in the male's right hand and left hand were 91.6±8.3 and 90.6±6.7, respectively. The ATD angle of the male right hand and female right hand were 53.1±1.2 and 50.4±1.7, respectively. There were significant differences in the distribution of ATD angles among males and females. Conclusion: The dermatoglyphics patterns of selected natives of the Irruan clan. However, this study has provided baseline information for further anthropological studies.

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“…diagnosticar diabetes cuando los niveles de glucosa en sangre superan un nivel de 6,5% en dos o más pruebas de hemoglobina glicosilada [5,6].…”

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Dermatoglifia como medio de hallazgo de diabetes mellitus: revisión sistemática

Castro-Jiménez

Hernandez

López

et al. 2022

Rev. Investig. Innov. Cienc. Salud

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Introducción. La diabetes mellitus (DM) es una de las enfermedades crónicas más comunes, siendo una de las causas principales de mortalidad de la población mundial. La dermatoglifia es empleada como instrumento para el hallazgo de ciertos aspectos biológicos en diferentes poblaciones. Objetivo. Reconocer, a partir de una revisión sistemática, la relevancia que tiene la dermatoglifia como medio de hallazgo de diabetes mellitus. Metodología. Revisión de literatura científica en bases de datos como Sciencedirect, PubMed, Scopus y BVS, en las cuales se extrajo información después de correr la ecuación de búsqueda con términos MESH. Posteriormente, fueron revisados para incluir aquellos artículos relacionados con DM y dermatoglifia. Para todo el proceso se siguió la metodología PRISMA, evaluando los artículos con la escala de sesgo de Cochrane y el nivel de evidencia y recomendación con escala SIGN. Resultados. Después de una revisión de 475 artículos, se incluyeron ocho artículos, y al ser evaluados fueron clasificados cinco artículos 2+ y tres 2-, con nivel de recomendación D. Conclusión. La dermatoglifía es una herramienta útil como medio de detección de la DM. Sin embargo, es necesario realizar estudios de cohortes para demostrarlo en diferentes poblaciones como la colombiana. En ese sentido, se encuentra que el 70% de los artículos revisados demuestran que la predicción de hallazgo de DM es efectiva. Sin embargo, el 30% de las investigaciones dentro de esta revisión no consideran que sea una herramienta lo suficientemente óptima para descubrir la patología en la población.

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Role of Dermatoglyphics as a Diagnostic Tool in Medical Disorders

Cited by 4 publications

References 54 publications

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

Digito-Palmar Dermatoglyphic Patterns among Natives of Irruan in Boki Local Government Area of Cross River State Nigeria

Dermatoglifia como medio de hallazgo de diabetes mellitus: revisión sistemática

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