Role of dextran in stabilization of polypyrrole nanoparticles for photoacoustic imaging

Paúrová, Monika; Taboubi, Oumayma; Šeděnková, Ivana; Hromádková, Jiřina; Matouš, Petr; Herynek, Vı́t; Šefc, Luděk; Babič, Michal

doi:10.1016/j.eurpolymj.2021.110634

Cited by 5 publications

(4 citation statements)

References 82 publications

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“…[ 28 ] In strong alkaline dispersion with a pH value approaching 14, a broad fluorescence band appeared and the original bands of PPy nearly disappeared due to the excitation of the overoxidized units. [ 29 ] The double peaks at 1052 and 1083 cm −1 were assigned to the CH in‐plane deformation, and another double peak at 1330 and 1370 cm −1 were attributed to the ring‐stretching mode of PPy. [ 30 ]…”

Section: Resultsmentioning

confidence: 99%

Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy

Geng,

Lupton,

et al. 2023

Adv Healthcare Materials

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The development of near‐infrared light responsive conductive polymers provides a useful theranostic platform for malignant tumors by maximizing spatial resolution with deep tissue penetration for diagnosis and photothermal therapy. Herein, the self‐assembly of ultrathin 2D polypyrrole nanosheets utilizing dopamine as a capping agent and a monolayer of octadecylamine as a template is demonstrated. The 2D polypyrrole‐polydopamine nanostructure has tunable size distribution which shows strong absorption in the first and second near‐infrared windows, enabling photoacoustic imaging and photothermal therapy. The hybrid double‐layer is demonstrated to increase Raman intensity for 3D Raman imaging (up to two orders of magnitude enhancement and spatial resolution up to 1 µm). The acidic environment drives reversible doping of polypyrrole, which can be detected by Raman spectroscopy. The combined properties of the nanosheets can substantially enhance performance in dual‐mode Raman and photoacoustic guided photothermal therapy, as shown by the 69% light to heat conversion efficiency and higher cytotoxicity against cancer spheroids. These pH‐responsive features highlight the potential of 2D conductive polymers for applications in accurate, highly efficient theranostics.

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Section: Resultsmentioning

confidence: 99%

Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy

Geng,

Lupton,

et al. 2023

Adv Healthcare Materials

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“…In the non-food industry, DEX is used as a bio-separation agent (Sephadex ® gels), or as a chromatographic media due to its non-ionic character and good stability under normal operating conditions or for the construction of universal calibration curves used in the evaluation of size exclusion chromatography results [ 37 ]. It is used as a steric dispersion stabiliser in the production process of polypyrrole NPs [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

Petrovici¹,

Pinteala²,

Simiónescu

2023

Molecules

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Dextran is by far one of the most interesting non-toxic, bio-compatible macromolecules, an exopolysaccharide biosynthesized by lactic acid bacteria. It has been extensively used as a major component in many types of drug-delivery systems (DDS), which can be submitted to the next in-vivo testing stages, and may be proposed for clinical trials or pharmaceutical use approval. An important aspect to consider in order to maintain high DDS’ biocompatibility is the use of dextran obtained by fermentation processes and with a minimum chemical modification degree. By performing chemical modifications, artefacts can appear in the dextran spatial structure that can lead to decreased biocompatibility or even cytotoxicity. The present review aims to systematize DDS depending on the dextran type used and the biologically active compounds transported, in order to obtain desired therapeutic effects. So far, pure dextran and modified dextran such as acetalated, oxidised, carboxymethyl, diethylaminoethyl-dextran and dextran sulphate sodium, were used to develop several DDSs: microspheres, microparticles, nanoparticles, nanodroplets, liposomes, micelles and nanomicelles, hydrogels, films, nanowires, bio-conjugates, medical adhesives and others. The DDS are critically presented by structures, biocompatibility, drugs loaded and therapeutic points of view in order to highlight future therapeutic perspectives.

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“…The photothermal potential of PPy particles for cancer treatment using NIR absorption was first demonstrated by Yang for material synthesized by aqueous-phase polymerization [22], where tumor growth was inhibited for the NIR laser irradiation (0.5 W/cm 2 ) of the PPy treated samples. The bioinert surface of polypyrrole makes it a prospective contrast agent for photoacoustic imaging [23] studied Materials 2023, 16, 7069 2 of 39 with the different steric stabilizers of the dispersion polymerization like dextran (Dex) [24]. Smart scaffolds aimed at improving the functionality of the cardiac tissue were proposed by blending PPy into silk fibroin (SF) [25].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, as we present in the current work, not only the chemical composition of the polymer chain but also the synthetic mode and procedure markedly influence the final material's performance. surface of polypyrrole makes it a prospective contrast agent for photoacoustic imaging [23] studied with the different steric stabilizers of the dispersion polymerization like dextran (Dex) [24]. Smart scaffolds aimed at improving the functionality of the cardiac tissue were proposed by blending PPy into silk fibroin (SF) [25].…”

Section: Introductionmentioning

confidence: 99%

The Alphabet of Nanostructured Polypyrrole

Golba,

Loskot

2023

Materials

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This review is devoted to polypyrrole and its morphology, which governs the electroactivity of the material. The macroscopic properties of the material are strictly relevant to microscopic ordering observed at the local level. During the synthesis, various (nano)morphologies can be produced. The formation of the ordered structure is dictated by the ability of the local forces and effects to induce restraints that help shape the structure. This review covers the aspects of morphology and roughness and their impact on the final properties of the modified electrode activity in selected applications.

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Role of dextran in stabilization of polypyrrole nanoparticles for photoacoustic imaging

Cited by 5 publications

References 82 publications

Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy

Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy

Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

The Alphabet of Nanostructured Polypyrrole

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