2018
DOI: 10.1016/j.abb.2018.08.001
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Role of DGAT enzymes in triacylglycerol metabolism

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Cited by 156 publications
(119 citation statements)
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“…DGAT2 localizes to areas between LDs and the ER to catalyze the synthesis of TAG from DAG and Acyl-CoA, and promote LD formation ( Figure 3C). [8] A study demonstrated that the expression of DGAT1 declined in adipocytes incubated with SFN for 48 h. [6] This, combined with our results here, suggests that SFN decreases TG synthesis by suppressing DGAT1/2 expression. ACAT1 is also a target for lipid metabolism regulation due to its ability to convert CHOL to CE for storage and to increase hepatic total and esterified cholesterol ( Figure 3C).…”
Section: Discussionsupporting
confidence: 79%
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“…DGAT2 localizes to areas between LDs and the ER to catalyze the synthesis of TAG from DAG and Acyl-CoA, and promote LD formation ( Figure 3C). [8] A study demonstrated that the expression of DGAT1 declined in adipocytes incubated with SFN for 48 h. [6] This, combined with our results here, suggests that SFN decreases TG synthesis by suppressing DGAT1/2 expression. ACAT1 is also a target for lipid metabolism regulation due to its ability to convert CHOL to CE for storage and to increase hepatic total and esterified cholesterol ( Figure 3C).…”
Section: Discussionsupporting
confidence: 79%
“…This study has demonstrated that SFN down‐regulates DGAT2 and ACAT1 both in vivo and in vitro. DGAT2 localizes to areas between LDs and the ER to catalyze the synthesis of TAG from DAG and Acyl‐CoA, and promote LD formation (Figure C) . A study demonstrated that the expression of DGAT1 declined in adipocytes incubated with SFN for 48 h .…”
Section: Discussionmentioning
confidence: 99%
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“…Although the level of DAG in the Golgi complex should be controlled, the fate of DAG co‐produced with SM is unclear. It may be converted to PtdCho by Golgi apparatus‐localising phosphocholine transferase or might be transported to the ER by a possible ceramide/DAG‐co‐exchange by CERT and metabolised to triacylglycerol by DAG acyltransferase or to PtdCho by phosphocholine/phosphoethanolamine transferase in the ER .…”
Section: Various Factors Involved In the Regulation Of Certmentioning
confidence: 99%