Role of diclofenac sodium and paracetamol on colonic anastomosis: An experimental rodent model

Gülçiçek, Osman Bilgin; Solmaz, Ali; Yiğitbaş, Hakan; Erçetin, Candaş; Yavuz, Erkan; Özdoğan, Kamil; Biricik, Aytaç; Akkalp, Aslı Kahraman; Uzun, Hafize; Kutnu, Müge; Çelebi, Fatih; Çelik, Atilla

doi:10.1016/j.asjsur.2017.01.002

“…These results were in accordance with the previous study that found metamizole tends to increase the incidence of anastomotic leakage [10]. In contrast, there was no significant inhibition in the anastomosis process of rat colon in the paracetamol group, which was supported by previous reports [11,12].…”

Section: Discussionsupporting

confidence: 93%

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

Purnomo

¹

,

Nugrahaningsih

²

,

Agustriani

³

et al. 2020

Preprint

0

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Background : Leakage following colorectal anastomosis surgery causes various complications associated with high morbidity and mortality, especially in pediatric patients. It might be caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs) as postoperative analgesics. This study aimed to compare the effect of metamizole and paracetamol on colonic anastomosis and fibroblast activities, including proliferation, migration, and collagen synthesis, in Wistar rats. Methods: Rats were divided into control, paracetamol and metamizole groups. The colonic anastomosis was evaluated by determining the integrity of the muscle layers, the formation of granulation tissue, and mucosal anastomosis. Fibroblast activities were analyzed by measuring the proliferation, migration, and collagen synthesis. Results: Metamizole caused more damage to muscle layer integrity, more inhibition of granulation tissue formation in the anastomosis area and lower mucosal anastomosis compared with paracetamol and control groups. Metamizole had a higher cytotoxic effect than paracetamol, which suppressed the proliferation and migration of fibroblasts. Furthermore, both drugs did not affect the synthesis of collagen. Conclusion: Metamizole shows worse effects on the integrity of muscle layers, inhibition of granulation tissue formation, mucosal anastomosis, fibroblast proliferation, and migration, but not collagen synthesis, than paracetamol in Wistar rat intestines following colonic anastomosis. These findings might indicate that paracetamol is safer than metamizole as analgesic following colonic anastomosis. Key Words: colonic anastomosis; fibroblast activities; metamizole; paracetamol; Wistar rat

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“…These results were in accordance with previous study that found metamizole tends to increase the incidence of anastomotic leakage [9]. In contrast, there was no significant inhibition in the anastomosis process of rat colon in the paracetamol group, which was supported by previous reports [10,11].…”

Section: Discussionsupporting

confidence: 93%

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

Purnomo

¹

,

Nugrahaningsih

²

,

Agustriani

³

et al. 2019

Preprint

0

View full text Add to dashboard Cite

Background: Leakage following colorectal anastomosis surgery causes various complications associated with high morbidity and mortality, especially in pediatric patients. It might be caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs) as postoperative analgesics. We aimed to compare the effect of metamizole and paracetamol on colonic anastomosis and fibroblast activities, including proliferation, migration, and collagen synthesis, in Wistar rats. Methods: We divided rats into control, paracetamol and metamizole groups. Colonic anastomosis was evaluated by determining the integrity of the muscle layers, formation of granulation tissue, and mucosal anastomosis. Fibroblast activities were analyzed by measuring the proliferation, migration, and collagen synthesis. Results: Metamizole caused more damage to muscle layer integrity, more inhibition of granulation tissue formation in the anastomosis area and lower mucosal anastomosis compared with paracetamol and control groups. Metamizole has a higher cytotoxic effect than paracetamol, which suppress the proliferation and migration of fibroblasts. Furthermore, both drugs did not affect the synthesis of collagen. Conclusion: Metamizole shows worse effects on integrity of muscle layers, inhibition of granulation tissue formation, mucosal anastomosis, fibroblast proliferation and migration, but not collagen synthesis, than paracetamol in Wistar rat intestines following colonic anastomosis. These findings might indicate that paracetamol is safer than metamizole as analgesic following colonic anastomosis. Keywords : colonic anastomosis; metamizole; paracetamol; fibroblast activities; Wistar rat

show abstract

“…These results were in accordance with the previous study that found metamizole tends to increase the incidence of anastomotic leakage [10]. In contrast, there was no significant inhibition in the anastomosis process of rat colon in the paracetamol group, which was supported by previous reports [11,12].…”

Section: Discussionsupporting

confidence: 93%

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

Purnomo

¹

,

Nugrahaningsih

²

,

Agustriani

³

et al. 2019

Preprint

0

View full text Add to dashboard Cite

Background : Leakage following colorectal anastomosis surgery causes various complications associated with high morbidity and mortality, especially in pediatric patients. It might be caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs) as postoperative analgesics. This study aimed to compare the effect of metamizole and paracetamol on colonic anastomosis and fibroblast activities, including proliferation, migration, and collagen synthesis, in Wistar rats. Methods: Rats were divided into control, paracetamol and metamizole groups. The colonic anastomosis was evaluated by determining the integrity of the muscle layers, the formation of granulation tissue, and mucosal anastomosis. Fibroblast activities were analyzed by measuring the proliferation, migration, and collagen synthesis. Results: Metamizole caused more damage to muscle layer integrity, more inhibition of granulation tissue formation in the anastomosis area and lower mucosal anastomosis compared with paracetamol and control groups. Metamizole had a higher cytotoxic effect than paracetamol, which suppressed the proliferation and migration of fibroblasts. Furthermore, both drugs did not affect the synthesis of collagen. Conclusion: Metamizole shows worse effects on the integrity of muscle layers, inhibition of granulation tissue formation, mucosal anastomosis, fibroblast proliferation, and migration, but not collagen synthesis, than paracetamol in Wistar rat intestines following colonic anastomosis. These findings might indicate that paracetamol is safer than metamizole as analgesic following colonic anastomosis. Key Words: colonic anastomosis; fibroblast activities; metamizole; paracetamol; Wistar rat

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Role of diclofenac sodium and paracetamol on colonic anastomosis: An experimental rodent model

Abstract: Bursting pressure, hydroxyproline levels, and fibrosis levels indicate that the perioperative use of paracetamol for analgesia when undergoing colonic anastomosis is safer than diclofenac sodium.

Cited by 11 publications

References 34 publications

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

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